IONS
アイオニス・ファーマシューティカルズ
Ionis Pharmaceuticals Inc
株価・概要
$75.26
-1.56 (-2.0307%)
06:00AM 2026/04/17 (JST)
NASDAQ | USD
52週間レンジ
27.57
86.74
昨夜レンジ
73.91
76.53
前日終値
$76.82
出来高（数量）
1,873,899
ベータ値
0.4
50日移動平均値
$77.94
200日移動平均値
$67.21
1株あたりの利益（EPS）
-2.38
予想PER（株価収益率）
90.91
配当金
$None
配当利回り
0%
インサイダー保有率
0.714%
機関投資家保有率
105.761%
IONS - 会社概要
アイオニス・ファーマシューティカルズ社（Ionis Pharmaceuticals, Inc.）は、カリフォルニア州カールスバッドに本拠を置く、先進的なRNA標的治療で知られるバイオ医薬品のイノベーターです。同社は独自のアンチセンス技術を活用し、神経疾患、心血管疾患、腫瘍学などの治療分野における重大かつ複雑な健康課題に取り組んでいます。自社および提携による強力なパイプラインを背景に、アイオニスは精密医療分野で優れた地位を確立しており、患者の治療成果を向上させる重要な進歩を推進しています。研究開発に強く注力することで、同社は業界リーダーとしての地位を確固たるものとし、バイオ医薬品分野における今後の成長と影響力の拡大が期待されています。
本社住所
2855 GAZELLE COURT, CARLSBAD, CA, UNITED STATES, 92010
企業サイト
https://www.ionis.com
会計年度終了
December
最新四半期
2025-12-31
利益・成長性
1株あたりの利益（EPS）
-$2.38
希薄化後1株当たり利益EPS（直近12ヶ月）
-$2.38
四半期利益成長率（前年比）
-43.7%
四半期売上成長率（前年比）
-10.3%
アナリスト予想・評価
目標株価
$96.81
強気
6
買い
10
ホールド
6
売り
0
弱気
0
EPS（1株当たり純利益）
| 7日前 | 30日前 | 60日前 | 90日前 | 予想レンジ | |||
|---|---|---|---|---|---|---|---|
配当履歴
| 権利落ち日 | 配当宣言日 | 権利確定日 | 配当金支払日 | 配当金額 |
|---|---|---|---|---|
| 2000-05-10 | None | None | None | $0.19 |
| 2000-04-18 | None | None | None | $0.11 |
| 2000-03-22 | None | None | None | $0.11 |
| 2000-02-17 | None | None | None | $0.11 |
| 1999-12-21 | None | None | None | $0.11 |
| 1999-11-17 | None | None | None | $0.11 |
| 1999-10-20 | None | None | None | $0.11 |
| 1999-09-21 | None | None | None | $0.11 |
| 1999-08-20 | None | None | None | $0.11 |
| 1999-07-21 | None | None | None | $0.11 |
| 1999-06-21 | None | None | None | $0.11 |
| 1999-05-20 | None | None | None | $0.11 |
| 1999-04-21 | None | None | None | $0.11 |
| 1999-03-22 | None | None | None | $0.11 |
| 1999-02-17 | None | None | None | $0.11 |
株式分割
| 効力発生日 | 分割比率 |
|---|
インサイダーの売却・購入履歴
| 自社株取引日 | 役員・従業員名 | 役員・従業員の役職 | 株式の種類 | 売却／購入 | 株数 | 株価 |
|---|---|---|---|---|---|---|
| 2026-04-02 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 6,193 | $74.05 |
| 2026-04-01 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 10,321 | $0.00 |
| 2026-04-01 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 12,000 | $38.06 |
| 2026-04-01 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 20,105 | $75.50 |
| 2026-04-01 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 2,216 | $75.95 |
| 2026-04-01 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 12,000 | $0.00 |
| 2026-04-01 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 10,321 | $41.08 |
| 2026-03-19 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 5,812 | $70.97 |
| 2026-03-17 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 10,172 | $73.21 |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 売却 | 33,118 | $0.00 |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 9,440 | $72.77 |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 205,608 | $72.38 |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 20,541 | $37.58 |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 33,118 | $32.60 |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 61,041 | $56.78 |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 60,299 | $60.89 |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 売却 | 60,299 | $0.00 |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 売却 | 61,041 | $0.00 |
| 2026-03-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 売却 | 20,541 | $0.00 |
| 2026-03-10 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | ストックオプション | 売却 | 4,675 | $0.00 |
| 2026-03-10 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | 普通株式 | 購入 | 4,675 | $34.69 |
| 2026-03-10 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | 普通株式 | 売却 | 16,086 | $76.30 |
| 2026-03-10 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | 普通株式 | 売却 | 21,191 | $75.50 |
| 2026-03-10 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 17,591 | $76.34 |
| 2026-03-10 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 16,512 | $75.47 |
| 2026-03-10 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 34,103 | $60.89 |
| 2026-03-10 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | 普通株式 | 購入 | 32,602 | $46.10 |
| 2026-03-10 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 売却 | 34,103 | $0.00 |
| 2026-03-10 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | ストックオプション | 売却 | 32,602 | $0.00 |
| 2026-03-09 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 117,604 | $75.26 |
| 2026-03-09 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 7,382 | $74.11 |
| 2026-03-09 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 売却 | 40,822 | $0.00 |
| 2026-03-09 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 売却 | 73,529 | $0.00 |
| 2026-03-09 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 73,529 | $60.89 |
| 2026-03-09 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 40,822 | $60.89 |
| 2026-03-09 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 10,148 | $75.25 |
| 2026-03-09 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 1,684 | $75.58 |
| 2026-03-04 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 売却 | 201 | $0.00 |
| 2026-03-04 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 201 | $32.60 |
| 2026-03-04 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 238 | $80.00 |
| 2026-03-04 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 238 | $56.78 |
| 2026-03-04 | LOSCALZO, JOSEPH | Director | ストックオプション | 売却 | 200 | $0.00 |
| 2026-03-04 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 200 | $38.06 |
| 2026-03-04 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 売却 | 238 | $0.00 |
| 2026-03-04 | LOSCALZO, JOSEPH | Director | 普通株式 | 売却 | 200 | $80.00 |
| 2026-03-04 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 201 | $80.00 |
| 2026-03-03 | DIAZ, ALLENE M. | Director | 普通株式 | 売却 | 14,608 | $79.88 |
| 2026-03-03 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 2,088 | $80.41 |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 売却 | 5,500 | $0.00 |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 755 | $80.84 |
| 2026-03-03 | DIAZ, ALLENE M. | Director | 普通株式 | 購入 | 18,000 | $40.05 |
| 2026-03-03 | DIAZ, ALLENE M. | Director | 普通株式 | 購入 | 12,000 | $38.06 |
| 2026-03-03 | DIAZ, ALLENE M. | Director | 普通株式 | 購入 | 10,321 | $41.08 |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 売却 | 6,951 | $0.00 |
| 2026-03-03 | LOSCALZO, JOSEPH | Director | ストックオプション | 売却 | 832 | $0.00 |
| 2026-03-03 | LOSCALZO, JOSEPH | Director | 普通株式 | 売却 | 832 | $80.33 |
| 2026-03-03 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 832 | $38.06 |
| 2026-03-03 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 802 | $80.76 |
| 2026-03-03 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 12,687 | $79.88 |
| 2026-03-03 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 71,600 | $79.10 |
| 2026-03-03 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 48,626 | $60.89 |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 5,030 | $80.00 |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 14,321 | $79.12 |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 385 | $52.87 |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 6,951 | $32.60 |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 5,500 | $34.69 |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 3,760 | $40.85 |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 3,510 | $37.58 |
| 2026-03-03 | DIAZ, ALLENE M. | Director | ストックオプション | 売却 | 10,321 | $0.00 |
| 2026-03-03 | DIAZ, ALLENE M. | Director | ストックオプション | 売却 | 18,000 | $0.00 |
| 2026-03-03 | DIAZ, ALLENE M. | Director | ストックオプション | 売却 | 12,000 | $0.00 |
| 2026-03-03 | DIAZ, ALLENE M. | Director | 普通株式 | 売却 | 1,005 | $80.80 |
| 2026-03-03 | DIAZ, ALLENE M. | Director | 普通株式 | 売却 | 39,265 | $79.11 |
| 2026-03-03 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 4,000 | $0.00 |
| 2026-03-03 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 12,000 | $0.00 |
| 2026-03-03 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 1,012 | $80.82 |
| 2026-03-03 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 6,794 | $80.00 |
| 2026-03-03 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 13,526 | $79.17 |
| 2026-03-03 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 4,000 | $42.88 |
| 2026-03-03 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 12,000 | $40.05 |
| 2026-03-03 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 36 | $81.01 |
| 2026-03-03 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 売却 | 879 | $0.00 |
| 2026-03-03 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 売却 | 820 | $0.00 |
| 2026-03-03 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 879 | $32.60 |
| 2026-03-03 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 820 | $56.78 |
| 2026-03-03 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 4,096 | $79.36 |
| 2026-03-03 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 売却 | 48,626 | $0.00 |
| 2026-03-03 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 売却 | 16,463 | $0.00 |
| 2026-03-03 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 16,463 | $32.60 |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 売却 | 385 | $0.00 |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 売却 | 3,760 | $0.00 |
| 2026-03-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 売却 | 3,510 | $0.00 |
| 2026-02-27 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 376 | $48.87 |
| 2026-02-27 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 購入 | 351 | $48.87 |
| 2026-02-27 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 256 | $48.87 |
| 2026-02-27 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 484 | $48.87 |
| 2026-02-27 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 261 | $48.87 |
| 2026-02-13 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 6,207 | $82.07 |
| 2026-02-13 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 9,435 | $81.56 |
| 2026-02-11 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 5,000 | $82.72 |
| 2026-02-06 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 29,430 | $85.79 |
| 2026-02-02 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 売却 | 48,626 | $0.00 |
| 2026-02-02 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 16,463 | $83.03 |
| 2026-02-02 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 売却 | 16,463 | $0.00 |
| 2026-02-02 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 48,626 | $83.03 |
| 2026-02-02 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 48,626 | $60.89 |
| 2026-02-02 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 0 | $0.00 |
| 2026-02-02 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 20,000 | $82.60 |
| 2026-02-02 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 16,463 | $32.60 |
| 2026-01-30 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 6,988 | $83.24 |
| 2026-01-30 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 6,179 | $83.45 |
| 2026-01-30 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 6,179 | $83.53 |
| 2026-01-30 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 6,179 | $82.93 |
| 2026-01-30 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 62,970 | $82.72 |
| 2026-01-30 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 売却 | 6,179 | $83.03 |
| 2026-01-30 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 5,885 | $82.95 |
| 2026-01-30 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 5,296 | $82.96 |
| 2026-01-29 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 購入 | 11,991 | $0.00 |
| 2026-01-29 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 10,278 | $0.00 |
| 2026-01-29 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 11,991 | $0.00 |
| 2026-01-29 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 122,214 | $0.00 |
| 2026-01-29 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 13,562 | $0.00 |
| 2026-01-29 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 購入 | 11,991 | $0.00 |
| 2026-01-29 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 11,421 | $0.00 |
| 2026-01-29 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 11,991 | $0.00 |
| 2026-01-22 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 3,977 | $81.34 |
| 2026-01-16 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 8,977 | $75.15 |
| 2026-01-16 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 49 | $75.97 |
| 2026-01-16 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 9,884 | $75.34 |
| 2026-01-16 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 8,353 | $75.95 |
| 2026-01-16 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 9,191 | $75.84 |
| 2026-01-16 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | 普通株式 | 売却 | 4,141 | $75.66 |
| 2026-01-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 12,922 | $75.22 |
| 2026-01-16 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 6,907 | $75.75 |
| 2026-01-16 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 44,034 | $74.82 |
| 2026-01-16 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 売却 | 8,480 | $75.11 |
| 2026-01-16 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 9,302 | $75.59 |
| 2026-01-16 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | 普通株式 | 売却 | 1,823 | $75.96 |
| 2026-01-16 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 1,149 | $75.78 |
| 2026-01-15 | YANG, MICHAEL J. | Director | 普通株式 | 購入 | 1,930 | $0.00 |
| 2026-01-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 購入 | 20,089 | $0.00 |
| 2026-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 2,850 | $0.00 |
| 2026-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 17,037 | $0.00 |
| 2026-01-15 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 譲渡制限付株式ユニット | 購入 | 9,675 | $0.00 |
| 2026-01-15 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 譲渡制限付株式ユニット | 売却 | 21,055 | $0.00 |
| 2026-01-15 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 譲渡制限付株式ユニット | 購入 | 25,800 | $0.00 |
| 2026-01-15 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 21,055 | $0.00 |
| 2026-01-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 譲渡制限付株式ユニット | 購入 | 9,675 | $0.00 |
| 2026-01-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 譲渡制限付株式ユニット | 売却 | 20,089 | $0.00 |
| 2026-01-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 譲渡制限付株式ユニット | 購入 | 25,800 | $0.00 |
| 2026-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 25,800 | $0.00 |
| 2026-01-15 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 譲渡制限付株式ユニット | 購入 | 9,675 | $0.00 |
| 2026-01-15 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 譲渡制限付株式ユニット | 売却 | 17,377 | $0.00 |
| 2026-01-15 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 譲渡制限付株式ユニット | 購入 | 25,800 | $0.00 |
| 2026-01-15 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 17,377 | $0.00 |
| 2026-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 12,885 | $0.00 |
| 2026-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 28,729 | $0.00 |
| 2026-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 34,360 | $0.00 |
| 2026-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 28,729 | $0.00 |
| 2026-01-15 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | 譲渡制限付株式ユニット | 売却 | 7,013 | $0.00 |
| 2026-01-15 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | 譲渡制限付株式ユニット | 購入 | 9,675 | $0.00 |
| 2026-01-15 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | 譲渡制限付株式ユニット | 購入 | 25,800 | $0.00 |
| 2026-01-15 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | 普通株式 | 購入 | 7,013 | $0.00 |
| 2026-01-15 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | 譲渡制限付株式ユニット | 購入 | 11,250 | $0.00 |
| 2026-01-15 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | 譲渡制限付株式ユニット | 購入 | 13,650 | $0.00 |
| 2026-01-15 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | 譲渡制限付株式ユニット | 売却 | 11,119 | $0.00 |
| 2026-01-15 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | 普通株式 | 購入 | 11,119 | $0.00 |
| 2026-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 購入 | 42,705 | $0.00 |
| 2026-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 売却 | 89,145 | $0.00 |
| 2026-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 購入 | 113,880 | $0.00 |
| 2026-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 89,145 | $0.00 |
| 2026-01-15 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 譲渡制限付株式ユニット | 購入 | 9,675 | $0.00 |
| 2026-01-15 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 譲渡制限付株式ユニット | 売却 | 21,473 | $0.00 |
| 2026-01-15 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 譲渡制限付株式ユニット | 購入 | 25,800 | $0.00 |
| 2026-01-15 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 21,473 | $0.00 |
| 2026-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 譲渡制限付株式ユニット | 購入 | 9,675 | $0.00 |
| 2026-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 譲渡制限付株式ユニット | 売却 | 21,685 | $0.00 |
| 2026-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 譲渡制限付株式ユニット | 購入 | 25,800 | $0.00 |
| 2026-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 購入 | 21,685 | $0.00 |
| 2026-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 購入 | 225 | $0.00 |
| 2026-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 売却 | 111 | $0.00 |
| 2026-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 購入 | 9,675 | $0.00 |
| 2026-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 売却 | 21,366 | $0.00 |
| 2026-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 購入 | 25,800 | $0.00 |
| 2026-01-15 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 111 | $0.00 |
| 2026-01-15 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 21,366 | $0.00 |
| 2026-01-15 | YANG, MICHAEL J. | Director | 譲渡制限付株式ユニット | 売却 | 1,930 | $0.00 |
| 2026-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 3,900 | $0.00 |
| 2026-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 売却 | 2,850 | $0.00 |
| 2026-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 9,675 | $0.00 |
| 2026-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 売却 | 17,037 | $0.00 |
| 2026-01-07 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 9,264 | $52.87 |
| 2026-01-07 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 3,829 | $84.62 |
| 2026-01-07 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 3,829 | $37.58 |
| 2026-01-07 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 売却 | 9,264 | $0.00 |
| 2026-01-07 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 売却 | 25,545 | $0.00 |
| 2026-01-07 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 25,545 | $56.78 |
| 2026-01-07 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 25,545 | $85.36 |
| 2026-01-07 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 2,101 | $32.60 |
| 2026-01-07 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 2,101 | $85.36 |
| 2026-01-07 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 3,460 | $32.60 |
| 2026-01-07 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 3,460 | $84.62 |
| 2026-01-07 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 売却 | 3,829 | $0.00 |
| 2026-01-07 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 売却 | 3,460 | $0.00 |
| 2026-01-07 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 売却 | 2,101 | $0.00 |
| 2026-01-07 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 9,264 | $84.62 |
| 2026-01-02 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | ストックオプション | 購入 | 9,100 | $0.00 |
| 2026-01-02 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | ストックオプション | 購入 | 7,500 | $0.00 |
| 2026-01-02 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 購入 | 2,600 | $0.00 |
| 2026-01-02 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 購入 | 19,350 | $0.00 |
| 2026-01-02 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 購入 | 19,350 | $0.00 |
| 2026-01-02 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | ストックオプション | 購入 | 19,350 | $0.00 |
| 2026-01-02 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 購入 | 19,350 | $0.00 |
| 2026-01-02 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 購入 | 25,770 | $0.00 |
| 2026-01-02 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 購入 | 85,410 | $0.00 |
| 2026-01-02 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 購入 | 19,350 | $0.00 |
| 2026-01-02 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | ストックオプション | 購入 | 19,350 | $0.00 |
| 2026-01-02 | SWAYZE, ERIC | EVP Research | ストックオプション | 購入 | 150 | $0.00 |
| 2026-01-02 | SWAYZE, ERIC | EVP Research | ストックオプション | 購入 | 19,350 | $0.00 |
| 2026-01-02 | SWAYZE, ERIC | EVP Research | ストックオプション | 売却 | 18,338 | $0.00 |
| 2026-01-02 | SWAYZE, ERIC | EVP Research | ストックオプション | 売却 | 5,125 | $0.00 |
| 2026-01-02 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 18,338 | $79.27 |
| 2026-01-02 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 18,338 | $60.89 |
| 2026-01-02 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 5,125 | $78.57 |
| 2026-01-02 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 5,125 | $60.89 |
| 2026-01-02 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | ストックオプション | 購入 | 19,350 | $0.00 |
| 2025-12-01 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 7,429 | $81.23 |
| 2025-12-01 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 20,571 | $80.67 |
| 2025-11-25 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 16,777 | $80.91 |
| 2025-11-25 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 売却 | 16,777 | $0.00 |
| 2025-11-25 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 4,000 | $0.00 |
| 2025-11-25 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 4,000 | $80.00 |
| 2025-11-25 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 4,000 | $0.00 |
| 2025-11-25 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 16,777 | $53.77 |
| 2025-11-19 | HERMAN, JOAN E | Director | ストックオプション | 売却 | 12,000 | $0.00 |
| 2025-11-19 | HERMAN, JOAN E | Director | 普通株式 | 売却 | 12,000 | $72.13 |
| 2025-11-19 | HERMAN, JOAN E | Director | 普通株式 | 購入 | 12,000 | $40.05 |
| 2025-11-19 | HERMAN, JOAN E | Director | ストックオプション | 売却 | 32,000 | $0.00 |
| 2025-11-19 | HERMAN, JOAN E | Director | 普通株式 | 購入 | 32,000 | $63.90 |
| 2025-11-19 | HERMAN, JOAN E | Director | 普通株式 | 売却 | 32,000 | $72.13 |
| 2025-11-18 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 16,000 | $24.42 |
| 2025-11-18 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 16,000 | $0.00 |
| 2025-11-06 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 18,300 | $60.89 |
| 2025-11-06 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 売却 | 8,000 | $76.17 |
| 2025-11-06 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 売却 | 14,738 | $0.00 |
| 2025-11-06 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 14,738 | $76.10 |
| 2025-11-06 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 売却 | 18,300 | $0.00 |
| 2025-11-06 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 18,300 | $75.42 |
| 2025-11-06 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 14,738 | $56.78 |
| 2025-11-05 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 売却 | 800 | $0.00 |
| 2025-11-05 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 801 | $75.01 |
| 2025-11-05 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 801 | $60.89 |
| 2025-11-05 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 800 | $75.01 |
| 2025-11-05 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 800 | $56.78 |
| 2025-11-05 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 売却 | 801 | $0.00 |
| 2025-11-03 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 775 | $75.05 |
| 2025-11-03 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 905 | $56.78 |
| 2025-11-03 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 905 | $75.05 |
| 2025-11-03 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 売却 | 905 | $0.00 |
| 2025-11-03 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 売却 | 775 | $0.00 |
| 2025-11-03 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 775 | $56.78 |
| 2025-11-03 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 905 | $60.89 |
| 2025-11-03 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 775 | $60.89 |
| 2025-10-31 | LOSCALZO, JOSEPH | Director | 普通株式 | 売却 | 16,000 | $75.10 |
| 2025-10-31 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 16,000 | $52.22 |
| 2025-10-31 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 11,200 | $75.16 |
| 2025-10-31 | LOSCALZO, JOSEPH | Director | ストックオプション | 売却 | 16,000 | $0.00 |
| 2025-10-31 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 34,585 | $60.89 |
| 2025-10-31 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 34,585 | $75.11 |
| 2025-10-31 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 34,664 | $56.78 |
| 2025-10-31 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 34,664 | $75.11 |
| 2025-10-31 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 20,000 | $75.11 |
| 2025-10-31 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 売却 | 34,664 | $0.00 |
| 2025-10-31 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 売却 | 34,585 | $0.00 |
| 2025-10-30 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 2,484 | $72.19 |
| 2025-10-30 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 8,341 | $73.16 |
| 2025-10-30 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 5,975 | $73.85 |
| 2025-10-16 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 1,263 | $73.62 |
| 2025-10-16 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 53 | $73.62 |
| 2025-10-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 購入 | 12,425 | $53.77 |
| 2025-10-15 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 6,000 | $48.51 |
| 2025-10-15 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 5,000 | $71.74 |
| 2025-10-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 売却 | 125 | $0.00 |
| 2025-10-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | ストックオプション | 売却 | 12,425 | $0.00 |
| 2025-10-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 売却 | 12,425 | $72.23 |
| 2025-10-15 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 125 | $0.00 |
| 2025-10-15 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 2,820 | $0.00 |
| 2025-10-15 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 譲渡制限付株式ユニット | 売却 | 2,820 | $0.00 |
| 2025-10-15 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 売却 | 6,000 | $0.00 |
| 2025-10-15 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 6,000 | $72.94 |
| 2025-10-14 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 購入 | 11,475 | $53.77 |
| 2025-10-14 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 売却 | 11,475 | $72.03 |
| 2025-10-14 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | ストックオプション | 売却 | 11,475 | $0.00 |
| 2025-10-06 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 1,625 | $69.37 |
| 2025-10-06 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 1,625 | $69.37 |
| 2025-10-06 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 10,200 | $52.87 |
| 2025-10-06 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 10,200 | $69.89 |
| 2025-10-06 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 6,849 | $69.02 |
| 2025-10-06 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 3,241 | $69.27 |
| 2025-10-06 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 売却 | 10,200 | $0.00 |
| 2025-10-06 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 437 | $69.26 |
| 2025-10-02 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 売却 | 34,461 | $0.00 |
| 2025-10-02 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 売却 | 15,000 | $0.00 |
| 2025-10-02 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 15,000 | $68.01 |
| 2025-10-02 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 15,000 | $31.80 |
| 2025-10-02 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 売却 | 30,203 | $0.00 |
| 2025-10-02 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 34,461 | $67.69 |
| 2025-10-02 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 34,461 | $60.89 |
| 2025-10-02 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 30,203 | $67.69 |
| 2025-10-02 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 30,203 | $56.78 |
| 2025-10-02 | SWAYZE, ERIC | EVP Research | ストックオプション | 売却 | 12,972 | $0.00 |
| 2025-10-02 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 12,972 | $66.23 |
| 2025-10-02 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 12,972 | $53.77 |
| 2025-10-01 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 16,800 | $65.50 |
| 2025-10-01 | SWAYZE, ERIC | EVP Research | ストックオプション | 売却 | 14,142 | $0.00 |
| 2025-10-01 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 14,142 | $66.09 |
| 2025-10-01 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 14,142 | $53.77 |
| 2025-09-30 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 売却 | 49,800 | $0.00 |
| 2025-09-30 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 14,827 | $56.78 |
| 2025-09-30 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 14,827 | $64.68 |
| 2025-09-30 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 売却 | 14,827 | $0.00 |
| 2025-09-30 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 57,900 | $53.77 |
| 2025-09-30 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 57,900 | $65.24 |
| 2025-09-30 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 売却 | 57,900 | $0.00 |
| 2025-09-30 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 49,800 | $53.77 |
| 2025-09-30 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 49,800 | $65.26 |
| 2025-09-29 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 売却 | 10,473 | $0.00 |
| 2025-09-29 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 10,473 | $64.54 |
| 2025-09-29 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 10,473 | $56.78 |
| 2025-09-12 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 1,700 | $56.78 |
| 2025-09-12 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 1,700 | $64.58 |
| 2025-09-12 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 売却 | 1,700 | $0.00 |
| 2025-09-09 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 20,000 | $64.56 |
| 2025-09-09 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 20,000 | $60.89 |
| 2025-09-09 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 売却 | 11,950 | $0.00 |
| 2025-09-09 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 11,950 | $62.16 |
| 2025-09-09 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 1,000 | $56.78 |
| 2025-09-09 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 11,950 | $31.80 |
| 2025-09-09 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 1,000 | $64.56 |
| 2025-09-09 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 売却 | 1,000 | $0.00 |
| 2025-09-09 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 売却 | 20,000 | $0.00 |
| 2025-09-05 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 250 | $31.80 |
| 2025-09-05 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 250 | $62.00 |
| 2025-09-05 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 売却 | 250 | $0.00 |
| 2025-09-05 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 6,000 | $59.60 |
| 2025-09-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 売却 | 2,234 | $0.00 |
| 2025-09-03 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 11,200 | $60.14 |
| 2025-09-03 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 102,900 | $53.77 |
| 2025-09-03 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 16,615 | $59.12 |
| 2025-09-03 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 42,030 | $37.58 |
| 2025-09-03 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 127,500 | $60.13 |
| 2025-09-03 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 31,316 | $32.60 |
| 2025-09-03 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 27,568 | $32.60 |
| 2025-09-03 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 59,699 | $61.06 |
| 2025-09-03 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 売却 | 31,316 | $0.00 |
| 2025-09-03 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 売却 | 27,568 | $0.00 |
| 2025-09-03 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 14,000 | $37.58 |
| 2025-09-03 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 65,475 | $60.89 |
| 2025-09-03 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 13,050 | $32.60 |
| 2025-09-03 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 11,375 | $61.42 |
| 2025-09-03 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 49,800 | $53.77 |
| 2025-09-03 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 売却 | 13,050 | $0.00 |
| 2025-09-03 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 売却 | 14,000 | $0.00 |
| 2025-09-03 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 売却 | 49,800 | $0.00 |
| 2025-09-03 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 46,800 | $53.77 |
| 2025-09-03 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 33,909 | $60.62 |
| 2025-09-03 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 売却 | 46,800 | $0.00 |
| 2025-09-03 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 16,000 | $24.42 |
| 2025-09-03 | LOSCALZO, JOSEPH | Director | 普通株式 | 売却 | 16,000 | $60.15 |
| 2025-09-03 | LOSCALZO, JOSEPH | Director | ストックオプション | 売却 | 16,000 | $0.00 |
| 2025-09-03 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 購入 | 19,658 | $53.77 |
| 2025-09-03 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 12,455 | $60.46 |
| 2025-09-03 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 7,203 | $61.42 |
| 2025-09-03 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | ストックオプション | 売却 | 19,658 | $0.00 |
| 2025-09-03 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 売却 | 42,030 | $0.00 |
| 2025-09-03 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 売却 | 102,900 | $0.00 |
| 2025-09-03 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 16,000 | $0.00 |
| 2025-09-03 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 12,000 | $0.00 |
| 2025-09-03 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 28,000 | $60.00 |
| 2025-09-03 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 12,000 | $0.00 |
| 2025-09-03 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 16,000 | $0.00 |
| 2025-09-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 2,234 | $37.58 |
| 2025-09-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 3,162 | $61.02 |
| 2025-09-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 928 | $32.60 |
| 2025-09-03 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 売却 | 928 | $0.00 |
| 2025-09-03 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 2,800 | $31.80 |
| 2025-09-03 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 2,800 | $62.01 |
| 2025-09-03 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 15,000 | $31.80 |
| 2025-09-03 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 30,000 | $59.09 |
| 2025-09-03 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 売却 | 2,800 | $0.00 |
| 2025-09-03 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 売却 | 15,000 | $0.00 |
| 2025-09-03 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 12,891 | $61.50 |
| 2025-09-02 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 10,750 | $50.42 |
| 2025-09-02 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 5,000 | $49.14 |
| 2025-09-02 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 売却 | 13,050 | $0.00 |
| 2025-09-02 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 10,000 | $49.22 |
| 2025-09-02 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 1,130 | $53.68 |
| 2025-09-02 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 11,200 | $55.04 |
| 2025-09-02 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 5,600 | $57.53 |
| 2025-09-02 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 13,050 | $54.51 |
| 2025-09-02 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 10,000 | $50.37 |
| 2025-09-02 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 13,050 | $32.60 |
| 2025-09-02 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 9,250 | $51.49 |
| 2025-08-29 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 331 | $27.71 |
| 2025-08-29 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 189 | $27.71 |
| 2025-08-29 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 165 | $27.71 |
| 2025-08-29 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 213 | $27.71 |
| 2025-08-29 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 購入 | 166 | $27.71 |
| 2025-08-22 | DIAZ, ALLENE M. | Director | 普通株式 | 売却 | 1,427 | $42.53 |
| 2025-08-18 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 売却 | 10,000 | $0.00 |
| 2025-08-18 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 10,000 | $43.98 |
| 2025-08-18 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 10,000 | $32.60 |
| 2025-08-06 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 4,600 | $41.87 |
| 2025-08-06 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 400 | $42.63 |
| 2025-08-05 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 10,000 | $42.86 |
| 2025-08-04 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 9,549 | $42.80 |
| 2025-07-30 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 売却 | 2,432 | $0.00 |
| 2025-07-30 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 2,432 | $45.00 |
| 2025-07-30 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 2,432 | $32.60 |
| 2025-07-15 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 4,079 | $0.00 |
| 2025-07-15 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 4,079 | $0.00 |
| 2025-07-15 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 4,079 | $0.00 |
| 2025-07-15 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 4,079 | $0.00 |
| 2025-07-15 | YANG, MICHAEL J. | Director | 普通株式 | 購入 | 4,079 | $0.00 |
| 2025-07-15 | YANG, MICHAEL J. | Director | 譲渡制限付株式ユニット | 売却 | 4,079 | $0.00 |
| 2025-07-15 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 4,079 | $0.00 |
| 2025-07-15 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 4,079 | $0.00 |
| 2025-07-15 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 4,079 | $0.00 |
| 2025-07-15 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 4,079 | $0.00 |
| 2025-07-15 | HERMAN, JOAN E | Director | 普通株式 | 購入 | 4,079 | $0.00 |
| 2025-07-15 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 売却 | 4,079 | $0.00 |
| 2025-07-15 | HAYDEN, MICHAEL R | Director | 普通株式 | 購入 | 4,079 | $0.00 |
| 2025-07-15 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 売却 | 4,079 | $0.00 |
| 2025-07-15 | DIAZ, ALLENE M. | Director | 普通株式 | 購入 | 4,079 | $0.00 |
| 2025-07-15 | DIAZ, ALLENE M. | Director | 譲渡制限付株式ユニット | 売却 | 4,079 | $0.00 |
| 2025-07-11 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 1,160 | $41.74 |
| 2025-07-01 | LOSCALZO, JOSEPH | Director | ストックオプション | 購入 | 11,518 | $0.00 |
| 2025-07-01 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 購入 | 5,220 | $0.00 |
| 2025-07-01 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 11,518 | $0.00 |
| 2025-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 購入 | 5,220 | $0.00 |
| 2025-07-01 | HERMAN, JOAN E | Director | ストックオプション | 購入 | 11,518 | $0.00 |
| 2025-07-01 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 購入 | 5,220 | $0.00 |
| 2025-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 購入 | 5,220 | $0.00 |
| 2025-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 11,518 | $0.00 |
| 2025-07-01 | HAYDEN, MICHAEL R | Director | ストックオプション | 購入 | 11,518 | $0.00 |
| 2025-07-01 | DIAZ, ALLENE M. | Director | 譲渡制限付株式ユニット | 購入 | 5,220 | $0.00 |
| 2025-07-01 | DIAZ, ALLENE M. | Director | ストックオプション | 購入 | 11,518 | $0.00 |
| 2025-07-01 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 購入 | 5,220 | $0.00 |
| 2025-07-01 | YANG, MICHAEL J. | Director | ストックオプション | 購入 | 11,518 | $0.00 |
| 2025-07-01 | YANG, MICHAEL J. | Director | 譲渡制限付株式ユニット | 購入 | 5,220 | $0.00 |
| 2025-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 11,518 | $0.00 |
| 2025-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 購入 | 5,220 | $0.00 |
| 2025-07-01 | PARSHALL, B LYNNE | Director | ストックオプション | 購入 | 11,518 | $0.00 |
| 2025-07-01 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 購入 | 5,220 | $0.00 |
| 2025-05-01 | HAYDEN, MICHAEL R | Director | 普通株式 | 購入 | 15,000 | $31.86 |
| 2025-04-16 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | 普通株式 | 売却 | 3,016 | $28.36 |
| 2025-04-16 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 3,928 | $28.40 |
| 2025-04-16 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 売却 | 680 | $28.37 |
| 2025-04-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 売却 | 10,837 | $0.00 |
| 2025-04-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 購入 | 1,875 | $0.00 |
| 2025-04-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2025-04-15 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | 普通株式 | 購入 | 12,226 | $0.00 |
| 2025-04-15 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | 譲渡制限付株式ユニット | 売却 | 12,226 | $0.00 |
| 2025-04-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 10,837 | $0.00 |
| 2025-03-11 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 140 | $32.32 |
| 2025-02-28 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 554 | $28.21 |
| 2025-02-28 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 415 | $28.21 |
| 2025-02-28 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 437 | $28.21 |
| 2025-02-28 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 415 | $28.21 |
| 2025-02-28 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 購入 | 414 | $28.21 |
| 2025-02-28 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 320 | $28.21 |
| 2025-02-20 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 1,207 | $32.35 |
| 2025-02-04 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 6,165 | $31.62 |
| 2025-02-04 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 38,843 | $31.65 |
| 2025-01-31 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 13,242 | $32.45 |
| 2025-01-31 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 1,327 | $32.46 |
| 2025-01-31 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 1,406 | $32.40 |
| 2025-01-31 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 1,523 | $32.44 |
| 2025-01-31 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 1,367 | $32.31 |
| 2025-01-31 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 1,484 | $32.20 |
| 2025-01-31 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 1,406 | $32.49 |
| 2025-01-30 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 購入 | 4,032 | $0.00 |
| 2025-01-30 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 3,607 | $0.00 |
| 2025-01-30 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 3,820 | $0.00 |
| 2025-01-30 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 3,820 | $0.00 |
| 2025-01-30 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 3,714 | $0.00 |
| 2025-01-30 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 25,372 | $0.00 |
| 2025-01-30 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 4,138 | $0.00 |
| 2025-01-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 8,870 | $32.81 |
| 2025-01-16 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 1,029 | $32.70 |
| 2025-01-16 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 3,401 | $32.70 |
| 2025-01-16 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 6,752 | $32.90 |
| 2025-01-16 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 売却 | 5,400 | $32.70 |
| 2025-01-16 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 7,072 | $32.86 |
| 2025-01-16 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 7,360 | $32.83 |
| 2025-01-16 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 6,523 | $32.79 |
| 2025-01-16 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 22 | $32.70 |
| 2025-01-16 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 7,154 | $32.84 |
| 2025-01-16 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 33,445 | $32.63 |
| 2025-01-16 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 売却 | 4,267 | $32.78 |
| 2025-01-15 | GEARY, RICHARD S | EVP, Chief Development Officer | 譲渡制限付株式ユニット | 売却 | 18,901 | $0.00 |
| 2025-01-15 | YANG, MICHAEL J. | Director | 普通株式 | 購入 | 1,931 | $0.00 |
| 2025-01-15 | YANG, MICHAEL J. | Director | 譲渡制限付株式ユニット | 売却 | 1,931 | $0.00 |
| 2025-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 3,750 | $0.00 |
| 2025-01-15 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 19,111 | $0.00 |
| 2025-01-15 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 49 | $0.00 |
| 2025-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 購入 | 22,000 | $0.00 |
| 2025-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 購入 | 33,000 | $0.00 |
| 2025-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 売却 | 19,111 | $0.00 |
| 2025-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 購入 | 245 | $0.00 |
| 2025-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 売却 | 49 | $0.00 |
| 2025-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 購入 | 17,372 | $0.00 |
| 2025-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 譲渡制限付株式ユニット | 購入 | 22,000 | $0.00 |
| 2025-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 譲渡制限付株式ユニット | 購入 | 33,000 | $0.00 |
| 2025-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 譲渡制限付株式ユニット | 売却 | 17,372 | $0.00 |
| 2025-01-15 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 19,690 | $0.00 |
| 2025-01-15 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 譲渡制限付株式ユニット | 購入 | 22,000 | $0.00 |
| 2025-01-15 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 譲渡制限付株式ユニット | 購入 | 33,000 | $0.00 |
| 2025-01-15 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 譲渡制限付株式ユニット | 売却 | 19,690 | $0.00 |
| 2025-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 73,448 | $0.00 |
| 2025-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 購入 | 169,950 | $0.00 |
| 2025-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 購入 | 129,395 | $0.00 |
| 2025-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 売却 | 73,448 | $0.00 |
| 2025-01-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 購入 | 14,283 | $0.00 |
| 2025-01-15 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 譲渡制限付株式ユニット | 売却 | 12,295 | $0.00 |
| 2025-01-15 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 譲渡制限付株式ユニット | 購入 | 33,000 | $0.00 |
| 2025-01-15 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 譲渡制限付株式ユニット | 購入 | 22,000 | $0.00 |
| 2025-01-15 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 普通株式 | 購入 | 12,295 | $0.00 |
| 2025-01-15 | GEARY, RICHARD S | EVP, Chief Development Officer | 譲渡制限付株式ユニット | 購入 | 33,000 | $0.00 |
| 2025-01-15 | GEARY, RICHARD S | EVP, Chief Development Officer | 譲渡制限付株式ユニット | 購入 | 22,000 | $0.00 |
| 2025-01-15 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 18,901 | $0.00 |
| 2025-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 23,887 | $0.00 |
| 2025-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 46,500 | $0.00 |
| 2025-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 31,000 | $0.00 |
| 2025-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 売却 | 2,460 | $0.00 |
| 2025-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 売却 | 8,787 | $0.00 |
| 2025-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 33,000 | $0.00 |
| 2025-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 22,000 | $0.00 |
| 2025-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 2,460 | $0.00 |
| 2025-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 8,787 | $0.00 |
| 2025-01-15 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 譲渡制限付株式ユニット | 売却 | 18,011 | $0.00 |
| 2025-01-15 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 譲渡制限付株式ユニット | 購入 | 33,000 | $0.00 |
| 2025-01-15 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 譲渡制限付株式ユニット | 購入 | 22,000 | $0.00 |
| 2025-01-15 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 18,011 | $0.00 |
| 2025-01-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 譲渡制限付株式ユニット | 売却 | 14,283 | $0.00 |
| 2025-01-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 譲渡制限付株式ユニット | 購入 | 33,000 | $0.00 |
| 2025-01-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 譲渡制限付株式ユニット | 購入 | 22,000 | $0.00 |
| 2025-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 23,887 | $0.00 |
| 2025-01-15 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | 譲渡制限付株式ユニット | 購入 | 28,050 | $0.00 |
| 2025-01-15 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | 譲渡制限付株式ユニット | 購入 | 18,700 | $0.00 |
| 2025-01-02 | SWAYZE, ERIC | EVP Research | ストックオプション | 購入 | 22,000 | $0.00 |
| 2025-01-02 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 購入 | 86,263 | $0.00 |
| 2025-01-02 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | ストックオプション | 購入 | 18,700 | $0.00 |
| 2025-01-02 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | ストックオプション | 購入 | 22,000 | $0.00 |
| 2025-01-02 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 購入 | 22,000 | $0.00 |
| 2025-01-02 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | ストックオプション | 購入 | 22,000 | $0.00 |
| 2025-01-02 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 購入 | 2,500 | $0.00 |
| 2025-01-02 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 購入 | 22,000 | $0.00 |
| 2025-01-02 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | ストックオプション | 購入 | 22,000 | $0.00 |
| 2025-01-02 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 購入 | 22,000 | $0.00 |
| 2025-01-02 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 購入 | 31,000 | $0.00 |
| 2025-01-02 | SWAYZE, ERIC | EVP Research | ストックオプション | 購入 | 163 | $0.00 |
| 2025-01-02 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 購入 | 22,000 | $0.00 |
| 2024-12-23 | HAYDEN, MICHAEL R | Director | 普通株式 | 購入 | 2,500 | $36.23 |
| 2024-12-23 | HAYDEN, MICHAEL R | Director | 普通株式 | 購入 | 2,500 | $36.20 |
| 2024-11-12 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 1,194 | $37.92 |
| 2024-11-12 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 6,630 | $38.05 |
| 2024-11-12 | LOSCALZO, JOSEPH | Director | 普通株式 | 売却 | 13,508 | $37.86 |
| 2024-10-16 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 53 | $38.31 |
| 2024-10-15 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 125 | $0.00 |
| 2024-10-15 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | 譲渡制限付株式ユニット | 購入 | 11,280 | $0.00 |
| 2024-10-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 売却 | 125 | $0.00 |
| 2024-09-29 | DEVERS, SHANNON L. | EVP, Chief Human Resourses Ofc | ストックオプション | 購入 | 15,040 | $0.00 |
| 2024-08-30 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 140 | $38.64 |
| 2024-08-30 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 246 | $38.64 |
| 2024-08-30 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 11 | $38.64 |
| 2024-08-30 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 177 | $38.64 |
| 2024-08-30 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 購入 | 12 | $38.64 |
| 2024-08-30 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 11 | $38.64 |
| 2024-08-29 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 331 | $49.63 |
| 2024-08-28 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 320 | $49.16 |
| 2024-08-05 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 2,430 | $48.00 |
| 2024-07-16 | DIAZ, ALLENE M. | Director | 普通株式 | 売却 | 900 | $48.94 |
| 2024-07-16 | DIAZ, ALLENE M. | Director | 普通株式 | 売却 | 737 | $50.17 |
| 2024-07-16 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 12,000 | $50.00 |
| 2024-07-16 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 12,000 | $24.42 |
| 2024-07-16 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 12,000 | $0.00 |
| 2024-07-15 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 4,677 | $0.00 |
| 2024-07-15 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 4,677 | $0.00 |
| 2024-07-15 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 4,677 | $0.00 |
| 2024-07-15 | HERMAN, JOAN E | Director | 普通株式 | 購入 | 4,677 | $0.00 |
| 2024-07-15 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 売却 | 4,677 | $0.00 |
| 2024-07-15 | DIAZ, ALLENE M. | Director | 普通株式 | 購入 | 4,677 | $0.00 |
| 2024-07-15 | DIAZ, ALLENE M. | Director | 譲渡制限付株式ユニット | 売却 | 4,677 | $0.00 |
| 2024-07-15 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 4,677 | $0.00 |
| 2024-07-15 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 4,677 | $0.00 |
| 2024-07-15 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 4,677 | $0.00 |
| 2024-07-15 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 4,677 | $0.00 |
| 2024-07-15 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 4,677 | $0.00 |
| 2024-07-01 | HAYDEN, MICHAEL R | Director | ストックオプション | 購入 | 10,111 | $0.00 |
| 2024-07-01 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 購入 | 4,079 | $0.00 |
| 2024-07-01 | PARSHALL, B LYNNE | Director | ストックオプション | 購入 | 10,111 | $0.00 |
| 2024-07-01 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 購入 | 4,079 | $0.00 |
| 2024-07-01 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 購入 | 4,079 | $0.00 |
| 2024-07-01 | DIAZ, ALLENE M. | Director | 譲渡制限付株式ユニット | 購入 | 4,079 | $0.00 |
| 2024-07-01 | DIAZ, ALLENE M. | Director | ストックオプション | 購入 | 10,111 | $0.00 |
| 2024-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 購入 | 4,079 | $0.00 |
| 2024-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 10,111 | $0.00 |
| 2024-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 購入 | 4,079 | $0.00 |
| 2024-07-01 | YANG, MICHAEL J. | Director | 譲渡制限付株式ユニット | 購入 | 4,079 | $0.00 |
| 2024-07-01 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 購入 | 4,079 | $0.00 |
| 2024-07-01 | HERMAN, JOAN E | Director | ストックオプション | 購入 | 10,111 | $0.00 |
| 2024-07-01 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 10,111 | $0.00 |
| 2024-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 10,111 | $0.00 |
| 2024-07-01 | YANG, MICHAEL J. | Director | ストックオプション | 購入 | 10,111 | $0.00 |
| 2024-07-01 | LOSCALZO, JOSEPH | Director | ストックオプション | 購入 | 10,111 | $0.00 |
| 2024-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 購入 | 4,079 | $0.00 |
| 2024-06-17 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 16,000 | $35.53 |
| 2024-06-17 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 16,000 | $40.29 |
| 2024-06-17 | BERTHELSEN, SPENCER R | Director | ストックオプション | 売却 | 16,000 | $0.00 |
| 2024-05-09 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 16,000 | $0.00 |
| 2024-05-09 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 16,000 | $35.53 |
| 2024-05-03 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 682 | $42.94 |
| 2024-05-03 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 1,318 | $42.57 |
| 2024-05-03 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 731 | $42.98 |
| 2024-05-03 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 1,269 | $42.59 |
| 2024-05-03 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 1,070 | $42.55 |
| 2024-05-03 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 930 | $42.90 |
| 2024-04-16 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 4,006 | $41.60 |
| 2024-04-16 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 売却 | 905 | $41.66 |
| 2024-04-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2024-04-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 購入 | 1,875 | $0.00 |
| 2024-04-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 売却 | 10,838 | $0.00 |
| 2024-04-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 10,838 | $0.00 |
| 2024-02-29 | BIRCHLER, BRIAN | Vice President Level 14 | 普通株式 | 購入 | 604 | $34.43 |
| 2024-02-29 | MONIA, BRETT P | Director, CEO Level 15 | 普通株式 | 購入 | 538 | $34.43 |
| 2024-02-29 | SWAYZE, ERIC | Officer Level 14 | 普通株式 | 購入 | 605 | $34.43 |
| 2024-02-29 | BENNETT, C FRANK | Officer Level 14 | 普通株式 | 購入 | 383 | $34.43 |
| 2024-02-29 | GEARY, RICHARD S | Officer Level 14 | 普通株式 | 購入 | 604 | $34.43 |
| 2024-02-26 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | ストックオプション | 購入 | 65,203 | $0.00 |
| 2024-02-16 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 387 | $44.49 |
| 2024-02-02 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 1,885 | $49.52 |
| 2024-02-02 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 2,106 | $49.59 |
| 2024-02-02 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 2,162 | $49.54 |
| 2024-02-02 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 23,907 | $49.37 |
| 2024-02-02 | CADORET-MANIER, ONAIZA | EVP,Chf GL Pdt Str & Oper Ofc | 普通株式 | 売却 | 2,162 | $49.60 |
| 2024-02-02 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 23,501 | $49.37 |
| 2024-02-02 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 1,995 | $50.04 |
| 2024-02-02 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 1,907 | $49.56 |
| 2024-02-02 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 2,125 | $49.54 |
| 2024-02-02 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 1,961 | $50.04 |
| 2024-02-02 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 1,940 | $49.56 |
| 2024-02-02 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 普通株式 | 売却 | 2,125 | $49.60 |
| 2024-02-02 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 1,853 | $49.52 |
| 2024-02-02 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 1,961 | $49.67 |
| 2024-02-02 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 2,071 | $49.59 |
| 2024-02-02 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 1,995 | $49.67 |
| 2024-02-01 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 25,372 | $0.00 |
| 2024-02-01 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 20,416 | $0.00 |
| 2024-02-01 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 購入 | 4,033 | $0.00 |
| 2024-02-01 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 4,140 | $0.00 |
| 2024-02-01 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 3,715 | $0.00 |
| 2024-02-01 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 3,820 | $0.00 |
| 2024-02-01 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 3,609 | $0.00 |
| 2024-02-01 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 普通株式 | 購入 | 4,140 | $0.00 |
| 2024-02-01 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 3,820 | $0.00 |
| 2024-01-31 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 10,773 | $52.00 |
| 2024-01-25 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 6,450 | $51.75 |
| 2024-01-25 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 2,285 | $51.75 |
| 2024-01-17 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 売却 | 4,497 | $50.42 |
| 2024-01-17 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 7,744 | $50.42 |
| 2024-01-17 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 普通株式 | 売却 | 5,564 | $50.42 |
| 2024-01-17 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 6,296 | $50.42 |
| 2024-01-17 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 564 | $50.42 |
| 2024-01-17 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 1,460 | $50.42 |
| 2024-01-17 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 6,745 | $50.42 |
| 2024-01-17 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 7,338 | $50.42 |
| 2024-01-17 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 8,683 | $50.42 |
| 2024-01-17 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 32,059 | $50.42 |
| 2024-01-17 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 5,482 | $50.42 |
| 2024-01-17 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 9 | $50.42 |
| 2024-01-16 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 20,641 | $0.00 |
| 2024-01-16 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 売却 | 1,353 | $0.00 |
| 2024-01-16 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 68,084 | $0.00 |
| 2024-01-16 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 譲渡制限付株式ユニット | 売却 | 12,080 | $0.00 |
| 2024-01-16 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 21 | $0.00 |
| 2024-01-16 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 購入 | 12,080 | $0.00 |
| 2024-01-16 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 売却 | 21 | $0.00 |
| 2024-01-16 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 購入 | 15,162 | $0.00 |
| 2024-01-16 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 譲渡制限付株式ユニット | 売却 | 15,162 | $0.00 |
| 2024-01-16 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 売却 | 68,084 | $10.00 |
| 2024-01-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 22,487 | $0.00 |
| 2024-01-16 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 22,487 | $0.00 |
| 2024-01-16 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 19,852 | $0.00 |
| 2024-01-16 | GEARY, RICHARD S | EVP, Chief Development Officer | 譲渡制限付株式ユニット | 売却 | 19,852 | $0.00 |
| 2024-01-16 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 18,314 | $0.00 |
| 2024-01-16 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 譲渡制限付株式ユニット | 売却 | 18,314 | $0.00 |
| 2024-01-16 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 3,688 | $0.00 |
| 2024-01-16 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 1,353 | $0.00 |
| 2024-01-16 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 17,069 | $0.00 |
| 2024-01-16 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 売却 | 17,069 | $0.00 |
| 2024-01-16 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 売却 | 3,688 | $0.00 |
| 2024-01-16 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 譲渡制限付株式ユニット | 売却 | 20,641 | $0.00 |
| 2024-01-16 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 普通株式 | 購入 | 15,062 | $0.00 |
| 2024-01-16 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 譲渡制限付株式ユニット | 売却 | 15,062 | $0.00 |
| 2024-01-15 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 譲渡制限付株式ユニット | 購入 | 32,400 | $0.00 |
| 2024-01-15 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 譲渡制限付株式ユニット | 購入 | 27,000 | $0.00 |
| 2024-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 譲渡制限付株式ユニット | 購入 | 17,000 | $0.00 |
| 2024-01-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 譲渡制限付株式ユニット | 購入 | 20,400 | $0.00 |
| 2024-01-15 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 譲渡制限付株式ユニット | 購入 | 17,000 | $0.00 |
| 2024-01-15 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 譲渡制限付株式ユニット | 購入 | 20,400 | $0.00 |
| 2024-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 17,000 | $0.00 |
| 2024-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 20,400 | $0.00 |
| 2024-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 1,800 | $0.00 |
| 2024-01-15 | YANG, MICHAEL J. | Director | 譲渡制限付株式ユニット | 購入 | 5,791 | $0.00 |
| 2024-01-15 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 譲渡制限付株式ユニット | 購入 | 17,000 | $0.00 |
| 2024-01-15 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 譲渡制限付株式ユニット | 購入 | 20,400 | $0.00 |
| 2024-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 購入 | 143,550 | $0.00 |
| 2024-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 購入 | 87,435 | $0.00 |
| 2024-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 27,000 | $0.00 |
| 2024-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 32,400 | $0.00 |
| 2024-01-15 | GEARY, RICHARD S | EVP, Chief Development Officer | 譲渡制限付株式ユニット | 購入 | 17,000 | $0.00 |
| 2024-01-15 | GEARY, RICHARD S | EVP, Chief Development Officer | 譲渡制限付株式ユニット | 購入 | 20,400 | $0.00 |
| 2024-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 2,625 | $0.00 |
| 2024-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 購入 | 116 | $0.00 |
| 2024-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 購入 | 20,400 | $0.00 |
| 2024-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 購入 | 17,000 | $0.00 |
| 2024-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 譲渡制限付株式ユニット | 購入 | 20,400 | $0.00 |
| 2024-01-15 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 譲渡制限付株式ユニット | 購入 | 17,000 | $0.00 |
| 2024-01-12 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | ストックオプション | 売却 | 8,000 | $0.00 |
| 2024-01-12 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 8,000 | $53.50 |
| 2024-01-12 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 購入 | 8,000 | $32.60 |
| 2024-01-02 | SWAYZE, ERIC | EVP Research | ストックオプション | 購入 | 27,200 | $0.00 |
| 2024-01-02 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 購入 | 27,200 | $0.00 |
| 2024-01-02 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | ストックオプション | 購入 | 27,200 | $0.00 |
| 2024-01-02 | SWAYZE, ERIC | EVP Research | ストックオプション | 購入 | 154 | $0.00 |
| 2024-01-02 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 購入 | 116,580 | $0.00 |
| 2024-01-02 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 購入 | 3,500 | $0.00 |
| 2024-01-02 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 購入 | 27,200 | $0.00 |
| 2024-01-02 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 購入 | 27,200 | $0.00 |
| 2024-01-02 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | ストックオプション | 購入 | 27,200 | $0.00 |
| 2024-01-02 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | ストックオプション | 購入 | 43,200 | $0.00 |
| 2024-01-02 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 購入 | 27,200 | $0.00 |
| 2024-01-02 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 購入 | 43,200 | $0.00 |
| 2023-12-28 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 42,525 | $50.19 |
| 2023-12-28 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 42,525 | $47.34 |
| 2023-12-28 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 43,798 | $50.50 |
| 2023-12-28 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 45,225 | $47.34 |
| 2023-12-28 | SWAYZE, ERIC | EVP Research | ストックオプション | 売却 | 27,100 | $0.00 |
| 2023-12-28 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 27,100 | $50.19 |
| 2023-12-28 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 売却 | 45,225 | $0.00 |
| 2023-12-28 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 購入 | 11,500 | $47.34 |
| 2023-12-28 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 売却 | 11,029 | $50.50 |
| 2023-12-28 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | ストックオプション | 売却 | 11,500 | $0.00 |
| 2023-12-28 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 27,100 | $47.34 |
| 2023-12-28 | PARSHALL, B LYNNE | Director | ストックオプション | 売却 | 42,525 | $0.00 |
| 2023-12-27 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 50,000 | $50.23 |
| 2023-12-27 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 50,000 | $47.34 |
| 2023-12-27 | PARSHALL, B LYNNE | Director | ストックオプション | 売却 | 50,000 | $0.00 |
| 2023-12-26 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 25,113 | $47.34 |
| 2023-12-26 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 売却 | 20,825 | $0.00 |
| 2023-12-26 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 20,825 | $47.34 |
| 2023-12-26 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 購入 | 25,000 | $47.34 |
| 2023-12-26 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 25,113 | $51.46 |
| 2023-12-26 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | ストックオプション | 売却 | 25,000 | $0.00 |
| 2023-12-26 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 20,825 | $51.46 |
| 2023-12-26 | PARSHALL, B LYNNE | Director | ストックオプション | 売却 | 25,113 | $0.00 |
| 2023-12-26 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 25,000 | $51.46 |
| 2023-12-21 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 16,113 | $47.34 |
| 2023-12-21 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 売却 | 4,112 | $0.00 |
| 2023-12-21 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 売却 | 16,113 | $0.00 |
| 2023-12-21 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 16,113 | $49.29 |
| 2023-12-21 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 売却 | 17,500 | $0.00 |
| 2023-12-21 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 17,500 | $47.34 |
| 2023-12-21 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 4,112 | $47.34 |
| 2023-12-21 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 4,112 | $49.29 |
| 2023-12-21 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 17,500 | $49.29 |
| 2023-12-20 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 6,500 | $47.34 |
| 2023-12-20 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 6,500 | $49.64 |
| 2023-12-20 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 売却 | 6,500 | $0.00 |
| 2023-12-20 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 6,500 | $49.64 |
| 2023-12-20 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 売却 | 6,500 | $0.00 |
| 2023-12-20 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 6,500 | $49.64 |
| 2023-12-20 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 売却 | 6,500 | $0.00 |
| 2023-12-20 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 6,500 | $47.34 |
| 2023-12-20 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 6,500 | $47.34 |
| 2023-12-14 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 売却 | 4,042 | $0.00 |
| 2023-12-14 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 6,571 | $49.21 |
| 2023-12-14 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 4,042 | $47.34 |
| 2023-12-14 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 4,042 | $50.19 |
| 2023-12-14 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 売却 | 6,571 | $0.00 |
| 2023-12-14 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 売却 | 14,002 | $0.00 |
| 2023-12-14 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 売却 | 8,610 | $0.00 |
| 2023-12-14 | YANG, MICHAEL J. | Director | ストックオプション | 購入 | 12,356 | $0.00 |
| 2023-12-14 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 14,860 | $47.34 |
| 2023-12-14 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 14,860 | $49.21 |
| 2023-12-14 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 9,140 | $47.34 |
| 2023-12-14 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 9,140 | $50.19 |
| 2023-12-14 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 売却 | 14,860 | $0.00 |
| 2023-12-14 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 売却 | 9,140 | $0.00 |
| 2023-12-14 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 6,571 | $47.34 |
| 2023-12-14 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 14,002 | $47.34 |
| 2023-12-14 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 14,002 | $49.21 |
| 2023-12-14 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 8,610 | $47.34 |
| 2023-12-14 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 8,610 | $50.19 |
| 2023-11-15 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 2,000 | $50.00 |
| 2023-10-17 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 52 | $47.95 |
| 2023-10-16 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 売却 | 125 | $0.00 |
| 2023-10-16 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 125 | $0.00 |
| 2023-10-12 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 3,770 | $46.00 |
| 2023-10-01 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 購入 | 2,400 | $0.00 |
| 2023-09-28 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 4,460 | $46.50 |
| 2023-09-26 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 10,000 | $45.13 |
| 2023-09-26 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 2,000 | $45.13 |
| 2023-08-31 | BENNETT, C FRANK | Officer Level 14 | 普通株式 | 購入 | 180 | $30.56 |
| 2023-08-31 | MONIA, BRETT P | Director, CEO Level 15 | 普通株式 | 購入 | 157 | $30.56 |
| 2023-08-31 | GEARY, RICHARD S | Officer Level 14 | 普通株式 | 購入 | 1 | $30.56 |
| 2023-08-01 | DIAZ, ALLENE M. | Director | 普通株式 | 売却 | 657 | $41.05 |
| 2023-07-18 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 3,555 | $42.00 |
| 2023-07-17 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 1,777 | $0.00 |
| 2023-07-17 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2023-07-17 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 1,777 | $0.00 |
| 2023-07-17 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2023-07-17 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2023-07-17 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 1,777 | $0.00 |
| 2023-07-17 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 1,777 | $0.00 |
| 2023-07-17 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 1,777 | $0.00 |
| 2023-07-17 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2023-07-17 | LOSCALZO, JOSEPH | Director, Director | 普通株式 | 購入 | 1,777 | $0.00 |
| 2023-07-17 | LOSCALZO, JOSEPH | Director, Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2023-07-17 | LOSCALZO, JOSEPH | Director, Director | 譲渡制限付株式ユニット | 売却 | 1,777 | $0.00 |
| 2023-07-17 | LOSCALZO, JOSEPH | Director, Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2023-07-17 | HAYDEN, MICHAEL R | Director | 普通株式 | 購入 | 1,777 | $0.00 |
| 2023-07-17 | HAYDEN, MICHAEL R | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2023-07-17 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 売却 | 1,777 | $0.00 |
| 2023-07-17 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2023-07-17 | DIAZ, ALLENE M. | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2023-07-17 | DIAZ, ALLENE M. | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2023-07-17 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 1,777 | $0.00 |
| 2023-07-17 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2023-07-17 | HERMAN, JOAN E | Director | 普通株式 | 購入 | 1,777 | $0.00 |
| 2023-07-17 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 1,777 | $0.00 |
| 2023-07-17 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2023-07-17 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 1,777 | $0.00 |
| 2023-07-17 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2023-07-17 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2023-07-17 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 売却 | 1,777 | $0.00 |
| 2023-07-17 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2023-07-17 | HERMAN, JOAN E | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2023-07-07 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 18,650 | $42.25 |
| 2023-07-03 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 10,321 | $0.00 |
| 2023-07-03 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 10,321 | $0.00 |
| 2023-07-03 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 購入 | 4,677 | $0.00 |
| 2023-07-03 | DIAZ, ALLENE M. | Director | ストックオプション | 購入 | 10,321 | $0.00 |
| 2023-07-03 | DIAZ, ALLENE M. | Director | 譲渡制限付株式ユニット | 購入 | 4,677 | $0.00 |
| 2023-07-03 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 購入 | 4,677 | $0.00 |
| 2023-07-03 | PARSHALL, B LYNNE | Director | ストックオプション | 購入 | 10,321 | $0.00 |
| 2023-07-03 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 購入 | 4,677 | $0.00 |
| 2023-07-03 | LOSCALZO, JOSEPH | Director, Director | ストックオプション | 購入 | 10,321 | $0.00 |
| 2023-07-03 | LOSCALZO, JOSEPH | Director, Director | 譲渡制限付株式ユニット | 購入 | 4,677 | $0.00 |
| 2023-07-03 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 10,321 | $0.00 |
| 2023-07-03 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 購入 | 4,677 | $0.00 |
| 2023-07-03 | HERMAN, JOAN E | Director | ストックオプション | 購入 | 10,321 | $0.00 |
| 2023-07-03 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 購入 | 4,677 | $0.00 |
| 2023-07-03 | HAYDEN, MICHAEL R | Director | ストックオプション | 購入 | 10,321 | $0.00 |
| 2023-07-03 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 購入 | 4,677 | $0.00 |
| 2023-06-20 | BERTHELSEN, SPENCER R | Director | ストックオプション | 売却 | 11,250 | $0.00 |
| 2023-06-20 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 11,250 | $28.47 |
| 2023-06-12 | HERMAN, JOAN E | Director | 普通株式 | 購入 | 3,555 | $0.00 |
| 2023-06-12 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 売却 | 3,555 | $0.00 |
| 2023-05-24 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 1,527 | $41.70 |
| 2023-05-22 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 2,630 | $40.14 |
| 2023-05-22 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 2,301 | $40.13 |
| 2023-04-18 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 売却 | 672 | $36.50 |
| 2023-04-18 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 3,880 | $36.50 |
| 2023-04-18 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 普通株式 | 売却 | 2,582 | $36.50 |
| 2023-04-17 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 譲渡制限付株式ユニット | 売却 | 5,667 | $0.00 |
| 2023-04-17 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 普通株式 | 購入 | 1,875 | $0.00 |
| 2023-04-17 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2023-04-17 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 売却 | 10,838 | $0.00 |
| 2023-04-17 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 普通株式 | 購入 | 5,667 | $0.00 |
| 2023-04-17 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 10,838 | $0.00 |
| 2023-02-28 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 301 | $30.52 |
| 2023-02-28 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 575 | $30.52 |
| 2023-02-28 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 383 | $30.52 |
| 2023-02-28 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 163 | $30.52 |
| 2023-02-28 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 575 | $30.52 |
| 2023-02-06 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 1,813 | $40.57 |
| 2023-02-06 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 1,920 | $40.86 |
| 2023-02-06 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 1,413 | $40.67 |
| 2023-02-06 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 24,651 | $40.69 |
| 2023-02-06 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 2,079 | $40.59 |
| 2023-02-06 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 1,920 | $40.66 |
| 2023-02-06 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 普通株式 | 売却 | 1,451 | $40.66 |
| 2023-02-06 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 1,815 | $40.79 |
| 2023-02-03 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 25,372 | $0.00 |
| 2023-02-03 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 3,609 | $0.00 |
| 2023-02-03 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 4,140 | $0.00 |
| 2023-02-03 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 購入 | 4,033 | $0.00 |
| 2023-02-03 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 17,210 | $0.00 |
| 2023-02-03 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 6,511 | $0.00 |
| 2023-02-03 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 普通株式 | 購入 | 4,140 | $0.00 |
| 2023-02-03 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 3,822 | $0.00 |
| 2023-02-03 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 3,715 | $0.00 |
| 2023-02-03 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 3,822 | $0.00 |
| 2023-01-31 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 4,500 | $39.71 |
| 2023-01-30 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 4,500 | $39.42 |
| 2023-01-18 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 25,066 | $39.49 |
| 2023-01-18 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 8,280 | $39.70 |
| 2023-01-18 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 7,873 | $39.57 |
| 2023-01-18 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 普通株式 | 売却 | 3,748 | $39.55 |
| 2023-01-18 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 6,978 | $38.89 |
| 2023-01-18 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 売却 | 375 | $39.79 |
| 2023-01-18 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 5,631 | $39.74 |
| 2023-01-18 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 4,752 | $39.57 |
| 2023-01-18 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 7,836 | $39.49 |
| 2023-01-17 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 売却 | 904 | $0.00 |
| 2023-01-17 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 譲渡制限付株式ユニット | 売却 | 19,417 | $0.00 |
| 2023-01-17 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 2,000 | $40.00 |
| 2023-01-17 | GEARY, RICHARD S | EVP, Chief Development Officer | 譲渡制限付株式ユニット | 売却 | 21,983 | $0.00 |
| 2023-01-17 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 21,983 | $0.00 |
| 2023-01-17 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 15,780 | $0.00 |
| 2023-01-17 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 19,417 | $0.00 |
| 2023-01-17 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 売却 | 15,780 | $0.00 |
| 2023-01-17 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 購入 | 13,046 | $0.00 |
| 2023-01-17 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 譲渡制限付株式ユニット | 売却 | 10,197 | $0.00 |
| 2023-01-17 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 譲渡制限付株式ユニット | 売却 | 13,046 | $0.00 |
| 2023-01-17 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 普通株式 | 購入 | 904 | $0.00 |
| 2023-01-17 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 21,871 | $0.00 |
| 2023-01-17 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 普通株式 | 購入 | 10,197 | $0.00 |
| 2023-01-17 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 譲渡制限付株式ユニット | 売却 | 21,871 | $0.00 |
| 2023-01-17 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 57,267 | $0.00 |
| 2023-01-17 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 23,154 | $0.00 |
| 2023-01-17 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 23,154 | $0.00 |
| 2023-01-17 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 売却 | 57,267 | $0.00 |
| 2023-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 1,800 | $0.00 |
| 2023-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 14,749 | $0.00 |
| 2023-01-15 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 譲渡制限付株式ユニット | 購入 | 13,656 | $0.00 |
| 2023-01-15 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 譲渡制限付株式ユニット | 購入 | 16,387 | $0.00 |
| 2023-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 購入 | 14,338 | $0.00 |
| 2023-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 購入 | 17,207 | $0.00 |
| 2023-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 購入 | 81 | $0.00 |
| 2023-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 譲渡制限付株式ユニット | 購入 | 14,338 | $0.00 |
| 2023-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 譲渡制限付株式ユニット | 購入 | 17,207 | $0.00 |
| 2023-01-15 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 譲渡制限付株式ユニット | 購入 | 14,338 | $0.00 |
| 2023-01-15 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 譲渡制限付株式ユニット | 購入 | 17,207 | $0.00 |
| 2023-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 購入 | 146,128 | $0.00 |
| 2023-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 購入 | 89,005 | $0.00 |
| 2023-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 16,216 | $0.00 |
| 2023-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 19,460 | $0.00 |
| 2023-01-15 | GEARY, RICHARD S | EVP, Chief Development Officer | 譲渡制限付株式ユニット | 購入 | 14,338 | $0.00 |
| 2023-01-15 | GEARY, RICHARD S | EVP, Chief Development Officer | 譲渡制限付株式ユニット | 購入 | 17,207 | $0.00 |
| 2023-01-15 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 譲渡制限付株式ユニット | 購入 | 16,216 | $0.00 |
| 2023-01-15 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | 譲渡制限付株式ユニット | 購入 | 19,460 | $0.00 |
| 2023-01-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 12,290 | $0.00 |
| 2023-01-03 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 購入 | 2,400 | $0.00 |
| 2023-01-03 | SWAYZE, ERIC | EVP Research | ストックオプション | 購入 | 22,942 | $0.00 |
| 2023-01-03 | SWAYZE, ERIC | EVP Research | ストックオプション | 購入 | 108 | $0.00 |
| 2023-01-03 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | ストックオプション | 購入 | 22,942 | $0.00 |
| 2023-01-03 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 購入 | 22,942 | $0.00 |
| 2023-01-03 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 購入 | 118,673 | $0.00 |
| 2023-01-03 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 購入 | 25,946 | $0.00 |
| 2023-01-03 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 購入 | 22,942 | $0.00 |
| 2023-01-03 | CADORET-MANIER, ONAIZA | EVP, Chf GL Pdt Str & Oper Ofc | ストックオプション | 購入 | 25,946 | $0.00 |
| 2023-01-03 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 購入 | 21,849 | $0.00 |
| 2023-01-03 | BAROLDI, JOSEPH | EVP, Chief Business Officer | ストックオプション | 購入 | 19,665 | $0.00 |
| 2022-10-17 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 売却 | 144 | $46.52 |
| 2022-10-17 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 売却 | 1,777 | $0.00 |
| 2022-10-17 | HAYDEN, MICHAEL R | Director | 普通株式 | 購入 | 1,777 | $0.00 |
| 2022-10-17 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 普通株式 | 購入 | 416 | $0.00 |
| 2022-10-17 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | 譲渡制限付株式ユニット | 売却 | 416 | $0.00 |
| 2022-10-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 購入 | 500 | $0.00 |
| 2022-09-19 | SWAYZE, ERIC | EVP Research | ストックオプション | 購入 | 1,000 | $0.00 |
| 2022-09-08 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 460 | $44.55 |
| 2022-08-31 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 183 | $28.97 |
| 2022-08-31 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 202 | $28.97 |
| 2022-08-31 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 108 | $28.97 |
| 2022-08-05 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 1 | $45.20 |
| 2022-07-15 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2022-07-15 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2022-07-15 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2022-07-15 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2022-07-15 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 2,665 | $0.00 |
| 2022-07-15 | LOSCALZO, JOSEPH | Director, Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2022-07-15 | LOSCALZO, JOSEPH | Director, Director | 普通株式 | 購入 | 2,665 | $0.00 |
| 2022-07-15 | LOSCALZO, JOSEPH | Director, Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2022-07-15 | LOSCALZO, JOSEPH | Director, Director | 譲渡制限付株式ユニット | 売却 | 2,665 | $0.00 |
| 2022-07-15 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2022-07-15 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,665 | $0.00 |
| 2022-07-15 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 689 | $37.74 |
| 2022-07-15 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 644 | $38.78 |
| 2022-07-15 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2022-07-15 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 2,665 | $0.00 |
| 2022-07-15 | HERMAN, JOAN E | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2022-07-15 | HERMAN, JOAN E | Director | 普通株式 | 購入 | 1,777 | $0.00 |
| 2022-07-15 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2022-07-15 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 売却 | 1,777 | $0.00 |
| 2022-07-15 | HAYDEN, MICHAEL R | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2022-07-15 | HAYDEN, MICHAEL R | Director | 普通株式 | 購入 | 1,777 | $0.00 |
| 2022-07-15 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2022-07-15 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 売却 | 1,777 | $0.00 |
| 2022-07-15 | DIAZ, ALLENE M. | Director | 普通株式 | 購入 | 8,000 | $0.00 |
| 2022-07-15 | DIAZ, ALLENE M. | Director | 譲渡制限付株式ユニット | 売却 | 8,000 | $0.00 |
| 2022-07-15 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2022-07-15 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 2,665 | $0.00 |
| 2022-07-15 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2022-07-15 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 2,665 | $0.00 |
| 2022-07-15 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 2,665 | $0.00 |
| 2022-07-15 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 2,665 | $0.00 |
| 2022-07-15 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2022-07-15 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 2,665 | $0.00 |
| 2022-07-15 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2022-07-15 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 2,665 | $0.00 |
| 2022-07-15 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 2,665 | $0.00 |
| 2022-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2022-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2022-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2022-07-01 | PARSHALL, B LYNNE | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2022-07-01 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2022-07-01 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 11,250 | $12.94 |
| 2022-07-01 | DIAZ, ALLENE M. | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2022-07-01 | DIAZ, ALLENE M. | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2022-07-01 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2022-07-01 | MUTO, FREDERICK T | Director | ストックオプション | 売却 | 11,250 | $0.00 |
| 2022-07-01 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2022-07-01 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2022-07-01 | HAYDEN, MICHAEL R | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2022-07-01 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2022-07-01 | HERMAN, JOAN E | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2022-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2022-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2022-07-01 | LOSCALZO, JOSEPH | Director, Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2022-07-01 | LOSCALZO, JOSEPH | Director, Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2022-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2022-06-10 | HERMAN, JOAN E | Director | 普通株式 | 購入 | 3,555 | $0.00 |
| 2022-06-10 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 売却 | 3,555 | $0.00 |
| 2022-06-07 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 11,250 | $12.94 |
| 2022-06-07 | BERTHELSEN, SPENCER R | Director | ストックオプション | 売却 | 11,250 | $0.00 |
| 2022-04-21 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 378 | $44.15 |
| 2022-04-18 | CADORET-MANIER, ONAIZA | EVP, Chf Pdt Str & Oper Ofc | 普通株式 | 購入 | 5,667 | $0.00 |
| 2022-04-18 | CADORET-MANIER, ONAIZA | EVP, Chf Pdt Str & Oper Ofc | 普通株式 | 売却 | 1,960 | $41.01 |
| 2022-04-18 | CADORET-MANIER, ONAIZA | EVP, Chf Pdt Str & Oper Ofc | 譲渡制限付株式ユニット | 売却 | 5,667 | $0.00 |
| 2022-04-15 | BAROLDI, JOSEPH | EVP, Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 43,350 | $0.00 |
| 2022-04-12 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 6,792 | $40.06 |
| 2022-04-01 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 355 | $37.49 |
| 2022-02-28 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 621 | $28.37 |
| 2022-02-28 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 621 | $28.37 |
| 2022-02-28 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 735 | $28.37 |
| 2022-02-28 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 621 | $28.37 |
| 2022-02-28 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 384 | $28.37 |
| 2022-02-28 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 346 | $28.37 |
| 2022-01-31 | BAROLDI, JOSEPH | Chief Business Officer | ストックオプション | 購入 | 86,700 | $0.00 |
| 2022-01-26 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 2,194 | $0.00 |
| 2022-01-26 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 14,004 | $0.00 |
| 2022-01-26 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 8,032 | $31.44 |
| 2022-01-18 | SWAYZE, ERIC | EVP Research | 普通株式 | 売却 | 4,994 | $30.12 |
| 2022-01-18 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 7,828 | $30.12 |
| 2022-01-18 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 22,050 | $0.00 |
| 2022-01-18 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 譲渡制限付株式ユニット | 売却 | 21,086 | $0.00 |
| 2022-01-18 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 19,714 | $30.12 |
| 2022-01-18 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 売却 | 7,501 | $30.12 |
| 2022-01-18 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 普通株式 | 購入 | 21,086 | $0.00 |
| 2022-01-18 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 譲渡制限付株式ユニット | 売却 | 18,842 | $0.00 |
| 2022-01-18 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 6,726 | $30.12 |
| 2022-01-18 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 18,842 | $0.00 |
| 2022-01-18 | CADORET-MANIER, ONAIZA | EVP, Chf Corp Dev and Cml Offc | 譲渡制限付株式ユニット | 売却 | 6,057 | $0.00 |
| 2022-01-18 | CADORET-MANIER, ONAIZA | EVP, Chf Corp Dev and Cml Offc | 普通株式 | 売却 | 2,305 | $30.12 |
| 2022-01-18 | CADORET-MANIER, ONAIZA | EVP, Chf Corp Dev and Cml Offc | 普通株式 | 購入 | 6,057 | $0.00 |
| 2022-01-18 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 5,754 | $0.00 |
| 2022-01-18 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 1,652 | $30.12 |
| 2022-01-18 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 5,754 | $0.00 |
| 2022-01-18 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 売却 | 49,475 | $0.00 |
| 2022-01-18 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 購入 | 21,391 | $0.00 |
| 2022-01-18 | GEARY, RICHARD S | EVP, Chief Development Officer | 普通株式 | 売却 | 7,605 | $30.12 |
| 2022-01-18 | GEARY, RICHARD S | EVP, Chief Development Officer | 譲渡制限付株式ユニット | 売却 | 21,391 | $0.00 |
| 2022-01-18 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 49,475 | $0.00 |
| 2022-01-18 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 22,050 | $0.00 |
| 2022-01-18 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Offc | 普通株式 | 購入 | 10,400 | $0.00 |
| 2022-01-18 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Offc | 普通株式 | 売却 | 3,815 | $30.12 |
| 2022-01-18 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Offc | 譲渡制限付株式ユニット | 売却 | 10,400 | $0.00 |
| 2022-01-18 | SWAYZE, ERIC | EVP Research | 普通株式 | 購入 | 13,809 | $0.00 |
| 2022-01-18 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 売却 | 13,809 | $0.00 |
| 2022-01-15 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 譲渡制限付株式ユニット | 購入 | 14,435 | $0.00 |
| 2022-01-15 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 譲渡制限付株式ユニット | 購入 | 10,826 | $0.00 |
| 2022-01-15 | CADORET-MANIER, ONAIZA | EVP, Chf Corp Dev and Cml Offc | 譲渡制限付株式ユニット | 購入 | 16,559 | $0.00 |
| 2022-01-15 | CADORET-MANIER, ONAIZA | EVP, Chf Corp Dev and Cml Offc | 譲渡制限付株式ユニット | 購入 | 12,419 | $0.00 |
| 2022-01-15 | GEARY, RICHARD S | EVP, Chief Development Officer | 譲渡制限付株式ユニット | 購入 | 15,284 | $0.00 |
| 2022-01-15 | GEARY, RICHARD S | EVP, Chief Development Officer | 譲渡制限付株式ユニット | 購入 | 11,463 | $0.00 |
| 2022-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 16,559 | $0.00 |
| 2022-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 12,419 | $0.00 |
| 2022-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 購入 | 50,745 | $0.00 |
| 2022-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 購入 | 76,117 | $0.00 |
| 2022-01-15 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 譲渡制限付株式ユニット | 購入 | 15,284 | $0.00 |
| 2022-01-15 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | 譲渡制限付株式ユニット | 購入 | 11,463 | $0.00 |
| 2022-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Offc | 譲渡制限付株式ユニット | 購入 | 16,133 | $0.00 |
| 2022-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Offc | 譲渡制限付株式ユニット | 購入 | 12,099 | $0.00 |
| 2022-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 購入 | 14,859 | $0.00 |
| 2022-01-15 | SWAYZE, ERIC | EVP Research | 譲渡制限付株式ユニット | 購入 | 11,144 | $0.00 |
| 2022-01-03 | SWAYZE, ERIC | EVP Research | ストックオプション | 購入 | 29,718 | $0.00 |
| 2022-01-03 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 購入 | 28,869 | $0.00 |
| 2022-01-03 | CADORET-MANIER, ONAIZA | EVP, Chf Corp Dev and Cml Offc | ストックオプション | 購入 | 33,118 | $0.00 |
| 2022-01-03 | GEARY, RICHARD S | EVP, Chief Development Officer | ストックオプション | 購入 | 30,567 | $0.00 |
| 2022-01-03 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 購入 | 33,118 | $0.00 |
| 2022-01-03 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 購入 | 101,489 | $0.00 |
| 2022-01-03 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | ストックオプション | 購入 | 30,567 | $0.00 |
| 2022-01-03 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Offc | ストックオプション | 購入 | 32,265 | $0.00 |
| 2021-10-15 | HAYDEN, MICHAEL R | Director | 普通株式 | 購入 | 1,777 | $0.00 |
| 2021-10-15 | REIKES, PETER N | Director | 譲渡制限付株式ユニット | 売却 | 1,777 | $0.00 |
| 2021-10-15 | REIKES, PETER N | Director | 普通株式 | 購入 | 1,777 | $0.00 |
| 2021-10-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Offc | 譲渡制限付株式ユニット | 売却 | 417 | $0.00 |
| 2021-10-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Offc | 普通株式 | 売却 | 145 | $35.10 |
| 2021-10-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Offc | 普通株式 | 購入 | 417 | $0.00 |
| 2021-10-15 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 売却 | 1,777 | $0.00 |
| 2021-08-31 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 166 | $33.80 |
| 2021-08-31 | CADORET-MANIER, ONAIZA | Chief Corp Dev and Cml Officer | 普通株式 | 購入 | 431 | $33.80 |
| 2021-08-31 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 355 | $33.80 |
| 2021-08-31 | O'NEIL, PATRICK R. | EVP Legal & General Counsel | 普通株式 | 購入 | 309 | $33.80 |
| 2021-08-31 | GEARY, RICHARD S | EVP, Chief Development Offc | 普通株式 | 購入 | 46 | $33.80 |
| 2021-08-31 | BENNETT, C FRANK | EVP & Chief Scientific Officer | 普通株式 | 購入 | 151 | $33.80 |
| 2021-07-15 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2021-07-15 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2021-07-15 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2021-07-15 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2021-07-15 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2021-07-15 | HERMAN, JOAN E | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2021-07-15 | HERMAN, JOAN E | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2021-07-15 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2021-07-15 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2021-07-15 | HAYDEN, MICHAEL R | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2021-07-15 | HAYDEN, MICHAEL R | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2021-07-15 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2021-07-15 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2021-07-15 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2021-07-15 | DIAZ, ALLENE M. | Director | 譲渡制限付株式ユニット | 購入 | 8,000 | $0.00 |
| 2021-07-15 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2021-07-15 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2021-07-15 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2021-07-15 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2021-07-15 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2021-07-15 | LOSCALZO, JOSEPH | Director, Chairman of Board | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2021-07-15 | LOSCALZO, JOSEPH | Director, Chairman of Board | 普通株式 | 購入 | 666 | $0.00 |
| 2021-07-15 | LOSCALZO, JOSEPH | Director, Chairman of Board | 普通株式 | 購入 | 889 | $0.00 |
| 2021-07-15 | LOSCALZO, JOSEPH | Director, Chairman of Board | 普通株式 | 購入 | 5,333 | $0.00 |
| 2021-07-15 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2021-07-15 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2021-07-15 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2021-07-15 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2021-07-15 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2021-07-15 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2021-07-15 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2021-07-15 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2021-07-15 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2021-07-15 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2021-07-15 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2021-07-15 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2021-07-15 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2021-07-15 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2021-07-15 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2021-07-15 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2021-07-15 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2021-07-15 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2021-07-15 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 4,334 | $35.30 |
| 2021-07-15 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2021-07-15 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2021-07-15 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2021-07-15 | LOSCALZO, JOSEPH | Director, Chairman of Board | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2021-07-15 | LOSCALZO, JOSEPH | Director, Chairman of Board | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2021-07-15 | LOSCALZO, JOSEPH | Director, Chairman of Board | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2021-07-15 | LOSCALZO, JOSEPH | Director, Chairman of Board | 普通株式 | 購入 | 1,778 | $0.00 |
| 2021-07-15 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2021-07-15 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2021-07-15 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2021-07-15 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2021-07-15 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2021-07-15 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2021-07-15 | REIKES, PETER N | Director | 普通株式 | 購入 | 5,333 | $0.00 |
| 2021-07-15 | REIKES, PETER N | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2021-07-15 | REIKES, PETER N | Director | 譲渡制限付株式ユニット | 売却 | 5,333 | $0.00 |
| 2021-07-15 | REIKES, PETER N | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2021-07-01 | LOSCALZO, JOSEPH | Director, Chairman of Board | ストックオプション | 購入 | 12,000 | $0.00 |
| 2021-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2021-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2021-07-01 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2021-07-01 | HAYDEN, MICHAEL R | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2021-07-01 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2021-07-01 | HERMAN, JOAN E | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2021-07-01 | DIAZ, ALLENE M. | Director | ストックオプション | 購入 | 18,000 | $0.00 |
| 2021-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2021-07-01 | LOSCALZO, JOSEPH | Director, Chairman of Board | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2021-07-01 | REIKES, PETER N | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2021-07-01 | PARSHALL, B LYNNE | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2021-07-01 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2021-07-01 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2021-07-01 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2021-07-01 | REIKES, PETER N | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2021-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2021-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2021-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2021-06-23 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 15,000 | $9.30 |
| 2021-06-23 | BERTHELSEN, SPENCER R | Director | ストックオプション | 売却 | 15,000 | $0.00 |
| 2021-06-23 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 15,000 | $37.74 |
| 2021-06-15 | MUTO, FREDERICK T | Director | 普通株式 | 売却 | 5,000 | $36.50 |
| 2021-06-15 | MUTO, FREDERICK T | Director | 普通株式 | 売却 | 5,000 | $36.85 |
| 2021-06-15 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 5,000 | $9.30 |
| 2021-06-15 | MUTO, FREDERICK T | Director | 普通株式 | 売却 | 5,000 | $36.55 |
| 2021-06-15 | MUTO, FREDERICK T | Director | ストックオプション | 売却 | 5,000 | $0.00 |
| 2021-06-10 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 売却 | 3,555 | $0.00 |
| 2021-06-10 | HERMAN, JOAN E | Director | 普通株式 | 購入 | 3,555 | $0.00 |
| 2021-04-15 | CADORET-MANIER, ONAIZA | Chief Corp Dev and Cml Officer | 譲渡制限付株式ユニット | 売却 | 5,667 | $0.00 |
| 2021-04-15 | CADORET-MANIER, ONAIZA | Chief Corp Dev and Cml Officer | 普通株式 | 購入 | 5,667 | $0.00 |
| 2021-04-15 | CADORET-MANIER, ONAIZA | Chief Corp Dev and Cml Officer | 普通株式 | 売却 | 1,960 | $41.03 |
| 2021-03-01 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 236 | $54.28 |
| 2021-02-26 | CADORET-MANIER, ONAIZA | Chief Corp Dev and Cml Officer | 普通株式 | 購入 | 492 | $44.54 |
| 2021-02-26 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 116 | $44.54 |
| 2021-02-26 | GEARY, RICHARD S | EVP, Chief Development Offc | 普通株式 | 購入 | 414 | $44.54 |
| 2021-02-26 | SWAYZE, ERIC | EVP, Research | 普通株式 | 購入 | 460 | $44.54 |
| 2021-02-26 | BENNETT, C FRANK | Chief Scientific Officer | 普通株式 | 購入 | 112 | $44.54 |
| 2021-02-26 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 247 | $44.54 |
| 2021-02-26 | O'NEIL, PATRICK R. | EVP & General Counsel | 普通株式 | 購入 | 197 | $44.54 |
| 2021-01-28 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 1,306 | $60.69 |
| 2021-01-28 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 2,634 | $0.00 |
| 2021-01-26 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 28,333 | $63.74 |
| 2021-01-25 | O'NEIL, PATRICK R. | EVP & General Counsel | 普通株式 | 売却 | 5,324 | $63.50 |
| 2021-01-22 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 40,000 | $61.68 |
| 2021-01-21 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 13,958 | $60.53 |
| 2021-01-21 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 21,042 | $61.65 |
| 2021-01-15 | GEARY, RICHARD S | EVP, Chief Development Offc | 譲渡制限付株式ユニット | 購入 | 22,714 | $0.00 |
| 2021-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 17,151 | $0.00 |
| 2021-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 34,823 | $0.00 |
| 2021-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 14,927 | $61.28 |
| 2021-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 購入 | 66,610 | $0.00 |
| 2021-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 購入 | 77,447 | $0.00 |
| 2021-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 売却 | 34,823 | $0.00 |
| 2021-01-15 | O'NEIL, PATRICK R. | EVP & General Counsel | 普通株式 | 購入 | 16,504 | $0.00 |
| 2021-01-15 | O'NEIL, PATRICK R. | EVP & General Counsel | 普通株式 | 売却 | 5,856 | $61.28 |
| 2021-01-15 | O'NEIL, PATRICK R. | EVP & General Counsel | 譲渡制限付株式ユニット | 購入 | 25,868 | $0.00 |
| 2021-01-15 | O'NEIL, PATRICK R. | EVP & General Counsel | 譲渡制限付株式ユニット | 売却 | 16,504 | $0.00 |
| 2021-01-15 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 10,655 | $0.00 |
| 2021-01-15 | SWAYZE, ERIC | EVP, Research | 譲渡制限付株式ユニット | 売却 | 8,944 | $0.00 |
| 2021-01-15 | CADORET-MANIER, ONAIZA | Chief Corp Dev and Cml Officer | 譲渡制限付株式ユニット | 購入 | 24,228 | $0.00 |
| 2021-01-15 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 譲渡制限付株式ユニット | 売却 | 4,371 | $0.00 |
| 2021-01-15 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 譲渡制限付株式ユニット | 売却 | 47,257 | $0.00 |
| 2021-01-15 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2021-01-15 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 1,434 | $61.28 |
| 2021-01-15 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 購入 | 4,371 | $0.00 |
| 2021-01-15 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 18,924 | $61.28 |
| 2021-01-15 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 購入 | 47,257 | $0.00 |
| 2021-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 17,151 | $0.00 |
| 2021-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 6,175 | $61.28 |
| 2021-01-15 | GEARY, RICHARD S | EVP, Chief Development Offc | 普通株式 | 売却 | 6,398 | $61.28 |
| 2021-01-15 | GEARY, RICHARD S | EVP, Chief Development Offc | 普通株式 | 購入 | 17,598 | $0.00 |
| 2021-01-15 | BENNETT, C FRANK | Chief Scientific Officer | 譲渡制限付株式ユニット | 売却 | 15,520 | $0.00 |
| 2021-01-15 | BENNETT, C FRANK | Chief Scientific Officer | 譲渡制限付株式ユニット | 購入 | 20,822 | $0.00 |
| 2021-01-15 | BENNETT, C FRANK | Chief Scientific Officer | 普通株式 | 売却 | 5,488 | $61.28 |
| 2021-01-15 | BENNETT, C FRANK | Chief Scientific Officer | 普通株式 | 購入 | 15,520 | $0.00 |
| 2021-01-15 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 27,129 | $0.00 |
| 2021-01-15 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 2,741 | $61.28 |
| 2021-01-15 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 10,655 | $0.00 |
| 2021-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Offc | 普通株式 | 購入 | 7,503 | $0.00 |
| 2021-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Offc | 普通株式 | 売却 | 2,718 | $61.28 |
| 2021-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Offc | 譲渡制限付株式ユニット | 購入 | 15,753 | $0.00 |
| 2021-01-15 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Offc | 譲渡制限付株式ユニット | 売却 | 7,503 | $0.00 |
| 2021-01-15 | SWAYZE, ERIC | EVP, Research | 普通株式 | 購入 | 8,944 | $0.00 |
| 2021-01-15 | SWAYZE, ERIC | EVP, Research | 普通株式 | 売却 | 3,216 | $61.28 |
| 2021-01-15 | SWAYZE, ERIC | EVP, Research | 譲渡制限付株式ユニット | 購入 | 23,976 | $0.00 |
| 2021-01-15 | GEARY, RICHARD S | EVP, Chief Development Offc | 譲渡制限付株式ユニット | 売却 | 17,598 | $0.00 |
| 2021-01-13 | GEARY, RICHARD S | EVP, Chief Development Offc | 普通株式 | 売却 | 141 | $59.50 |
| 2021-01-05 | SWAYZE, ERIC | EVP, Research | 普通株式 | 売却 | 195 | $55.99 |
| 2021-01-04 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | ストックオプション | 購入 | 12,000 | $0.00 |
| 2021-01-04 | BENNETT, C FRANK | Chief Scientific Officer | ストックオプション | 購入 | 46,850 | $0.00 |
| 2021-01-04 | SWAYZE, ERIC | EVP, Research | ストックオプション | 購入 | 53,945 | $0.00 |
| 2021-01-04 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Offc | ストックオプション | 購入 | 35,444 | $0.00 |
| 2021-01-04 | CADORET-MANIER, ONAIZA | Chief Corp Dev and Cml Officer | ストックオプション | 購入 | 54,513 | $0.00 |
| 2021-01-04 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 購入 | 61,041 | $0.00 |
| 2021-01-04 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 購入 | 149,872 | $0.00 |
| 2021-01-04 | O'NEIL, PATRICK R. | EVP & General Counsel | ストックオプション | 購入 | 58,203 | $0.00 |
| 2021-01-04 | GEARY, RICHARD S | EVP, Development | ストックオプション | 購入 | 51,107 | $0.00 |
| 2020-12-23 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 10,000 | $60.00 |
| 2020-12-17 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 1,407 | $50.50 |
| 2020-12-15 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 39,000 | $49.78 |
| 2020-12-07 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 6,000 | $51.50 |
| 2020-12-07 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 5,000 | $51.87 |
| 2020-12-04 | BENNETT, C FRANK | Chief Scientific Officer | 普通株式 | 売却 | 7,947 | $51.04 |
| 2020-12-04 | BENNETT, C FRANK | Chief Scientific Officer | 普通株式 | 購入 | 7,947 | $39.87 |
| 2020-12-04 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 売却 | 23,840 | $0.00 |
| 2020-12-04 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 23,840 | $51.04 |
| 2020-12-04 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 23,840 | $39.87 |
| 2020-12-04 | BENNETT, C FRANK | Chief Scientific Officer | ストックオプション | 売却 | 7,947 | $0.00 |
| 2020-12-02 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 売却 | 21,160 | $0.00 |
| 2020-12-02 | BENNETT, C FRANK | Chief Scientific Officer | 普通株式 | 購入 | 7,053 | $39.87 |
| 2020-12-02 | BENNETT, C FRANK | Chief Scientific Officer | 普通株式 | 売却 | 7,053 | $51.32 |
| 2020-12-02 | BENNETT, C FRANK | Chief Scientific Officer | ストックオプション | 売却 | 7,053 | $0.00 |
| 2020-12-02 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 21,160 | $39.87 |
| 2020-12-02 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 21,160 | $51.32 |
| 2020-11-25 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 購入 | 12,990 | $39.87 |
| 2020-11-25 | GEARY, RICHARD S | EVP, Development | 普通株式 | 購入 | 11,920 | $39.87 |
| 2020-11-25 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | ストックオプション | 売却 | 12,990 | $0.00 |
| 2020-11-25 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 3,590 | $39.87 |
| 2020-11-25 | GEARY, RICHARD S | EVP, Development | ストックオプション | 売却 | 11,920 | $0.00 |
| 2020-11-25 | GEARY, RICHARD S | EVP, Development | 普通株式 | 売却 | 11,920 | $50.05 |
| 2020-11-25 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 売却 | 21,680 | $0.00 |
| 2020-11-25 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 21,680 | $50.05 |
| 2020-11-25 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 21,680 | $39.87 |
| 2020-11-25 | PARSHALL, B LYNNE | Director | ストックオプション | 売却 | 3,590 | $0.00 |
| 2020-11-25 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 3,590 | $50.05 |
| 2020-11-25 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 12,990 | $50.05 |
| 2020-11-24 | GEARY, RICHARD S | EVP, Development | ストックオプション | 売却 | 2,380 | $0.00 |
| 2020-11-24 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 売却 | 4,320 | $0.00 |
| 2020-11-24 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 710 | $39.87 |
| 2020-11-24 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 710 | $50.82 |
| 2020-11-24 | PARSHALL, B LYNNE | Director | ストックオプション | 売却 | 710 | $0.00 |
| 2020-11-24 | GEARY, RICHARD S | EVP, Development | 普通株式 | 売却 | 2,380 | $50.83 |
| 2020-11-24 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 購入 | 2,590 | $39.87 |
| 2020-11-24 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | ストックオプション | 売却 | 2,590 | $0.00 |
| 2020-11-24 | GEARY, RICHARD S | EVP, Development | 普通株式 | 購入 | 2,380 | $39.87 |
| 2020-11-24 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 2,590 | $50.83 |
| 2020-11-24 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 4,320 | $39.87 |
| 2020-11-24 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 4,320 | $50.83 |
| 2020-11-23 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 13,125 | $39.87 |
| 2020-11-23 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 11,600 | $50.11 |
| 2020-11-23 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 購入 | 11,600 | $39.87 |
| 2020-11-23 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 500 | $50.00 |
| 2020-11-23 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 購入 | 500 | $39.87 |
| 2020-11-23 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 3,200 | $50.12 |
| 2020-11-23 | PARSHALL, B LYNNE | Director | ストックオプション | 売却 | 3,200 | $0.00 |
| 2020-11-23 | GEARY, RICHARD S | EVP, Development | 普通株式 | 売却 | 10,700 | $50.11 |
| 2020-11-23 | GEARY, RICHARD S | EVP, Development | 普通株式 | 購入 | 10,700 | $39.87 |
| 2020-11-23 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 5,875 | $50.11 |
| 2020-11-23 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 5,875 | $39.87 |
| 2020-11-23 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 売却 | 13,125 | $50.11 |
| 2020-11-23 | GEARY, RICHARD S | EVP, Development | ストックオプション | 売却 | 10,700 | $0.00 |
| 2020-11-23 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 売却 | 5,875 | $0.00 |
| 2020-11-23 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | ストックオプション | 売却 | 13,125 | $0.00 |
| 2020-11-23 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 3,200 | $39.87 |
| 2020-11-23 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | ストックオプション | 売却 | 500 | $0.00 |
| 2020-11-23 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | ストックオプション | 売却 | 11,600 | $0.00 |
| 2020-11-03 | BENNETT, C FRANK | Chief Scientific Officer | 普通株式 | 購入 | 15,000 | $39.87 |
| 2020-11-03 | BENNETT, C FRANK | Chief Scientific Officer | 普通株式 | 売却 | 15,000 | $46.77 |
| 2020-11-03 | BENNETT, C FRANK | Chief Scientific Officer | ストックオプション | 売却 | 15,000 | $0.00 |
| 2020-10-20 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 2,889 | $46.86 |
| 2020-10-15 | REIKES, PETER N | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2020-10-15 | REIKES, PETER N | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2020-10-15 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2020-10-15 | HAYDEN, MICHAEL R | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2020-10-10 | IONIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 購入 | 21,237,715 | $18.15 |
| 2020-09-22 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 50,000 | $50.41 |
| 2020-09-21 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 2,000 | $50.18 |
| 2020-09-16 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 11,250 | $12.94 |
| 2020-09-16 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 11,250 | $28.47 |
| 2020-09-16 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 11,250 | $0.00 |
| 2020-09-01 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 314 | $53.70 |
| 2020-08-31 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | 普通株式 | 購入 | 121 | $44.46 |
| 2020-08-31 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 236 | $44.46 |
| 2020-08-31 | GEARY, RICHARD S | EVP, Development | 普通株式 | 購入 | 1 | $44.46 |
| 2020-08-31 | O'NEIL, PATRICK R. | EVP & General Counsel | 普通株式 | 購入 | 169 | $44.46 |
| 2020-08-31 | SWAYZE, ERIC | EVP, Research | 普通株式 | 購入 | 1 | $44.46 |
| 2020-08-31 | BENNETT, C FRANK | Chief Scientific Officer | 普通株式 | 購入 | 112 | $44.46 |
| 2020-07-06 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2020-07-06 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2020-07-06 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2020-07-06 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2020-07-06 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2020-07-06 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2020-07-06 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2020-07-06 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2020-07-06 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2020-07-06 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2020-07-06 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2020-07-06 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2020-07-02 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2020-07-02 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2020-07-02 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2020-07-02 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2020-07-02 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2020-07-02 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2020-07-02 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2020-07-02 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2020-07-02 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2020-07-02 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2020-07-02 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2020-07-02 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2020-07-02 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2020-07-02 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2020-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2020-07-01 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2020-07-01 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2020-07-01 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2020-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2020-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2020-07-01 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2020-07-01 | REIKES, PETER N | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2020-07-01 | REIKES, PETER N | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2020-07-01 | CASTLEMAN, BREAUX | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2020-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2020-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2020-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2020-07-01 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2020-07-01 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2020-07-01 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2020-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2020-07-01 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2020-07-01 | REIKES, PETER N | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2020-07-01 | REIKES, PETER N | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2020-07-01 | PARSHALL, B LYNNE | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2020-07-01 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2020-07-01 | LOSCALZO, JOSEPH | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2020-07-01 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2020-07-01 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2020-07-01 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2020-07-01 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2020-07-01 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2020-07-01 | HERMAN, JOAN E | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2020-07-01 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2020-07-01 | HERMAN, JOAN E | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2020-07-01 | HAYDEN, MICHAEL R | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2020-07-01 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2020-07-01 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2020-07-01 | HAYDEN, MICHAEL R | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2020-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2020-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2020-07-01 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2020-07-01 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2020-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2020-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2020-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2020-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2020-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2020-07-01 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 12,000 | $0.00 |
| 2020-07-01 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2020-07-01 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2020-07-01 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2020-07-01 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2020-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2020-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2020-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 購入 | 5,333 | $0.00 |
| 2020-06-30 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 15,000 | $9.22 |
| 2020-06-30 | MUTO, FREDERICK T | Director | ストックオプション | 売却 | 15,000 | $0.00 |
| 2020-06-25 | CASTLEMAN, BREAUX | Director | ストックオプション | 売却 | 10,000 | $0.00 |
| 2020-06-25 | CASTLEMAN, BREAUX | Director | 普通株式 | 売却 | 10,000 | $60.00 |
| 2020-06-25 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 9,914 | $60.11 |
| 2020-06-25 | BENNETT, C FRANK | EVP, Chief Scientific Officer | ストックオプション | 売却 | 15,000 | $0.00 |
| 2020-06-25 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 売却 | 15,000 | $59.77 |
| 2020-06-25 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 10,000 | $26.66 |
| 2020-06-25 | BENNETT, C FRANK | EVP, Chief Scientific Officer | 普通株式 | 購入 | 15,000 | $39.87 |
| 2020-06-24 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 5,000 | $58.80 |
| 2020-06-23 | BERTHELSEN, SPENCER R | Director | ストックオプション | 売却 | 15,000 | $0.00 |
| 2020-06-23 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 15,000 | $58.76 |
| 2020-06-23 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 15,000 | $9.22 |
| 2020-06-19 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 10,000 | $58.33 |
| 2020-06-17 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 15,000 | $57.90 |
| 2020-06-17 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 2,000 | $58.25 |
| 2020-06-10 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 売却 | 3,556 | $0.00 |
| 2020-06-10 | HERMAN, JOAN E | Director | 普通株式 | 購入 | 3,556 | $0.00 |
| 2020-04-15 | CADORET-MANIER, ONAIZA | Chief Corp Dev and Cml Officer | 譲渡制限付株式ユニット | 購入 | 22,667 | $0.00 |
| 2020-03-25 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 1,000 | $47.00 |
| 2020-03-25 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 15,000 | $47.00 |
| 2020-03-19 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 5,000 | $46.00 |
| 2020-03-19 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 1,000 | $45.00 |
| 2020-03-19 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 10,000 | $44.75 |
| 2020-03-17 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 5,651 | $45.00 |
| 2020-03-17 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 4,349 | $45.00 |
| 2020-03-17 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 5,651 | $45.00 |
| 2020-03-17 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 5,421 | $44.50 |
| 2020-03-17 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 4,579 | $44.50 |
| 2020-03-17 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 4,349 | $45.00 |
| 2020-03-17 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 4,969 | $44.50 |
| 2020-03-17 | CROOKE, STANLEY T | Director, Exec Chairman of the Board | 普通株式 | 売却 | 5,421 | $44.50 |
| 2020-02-29 | SWAYZE, ERIC | SVP, Research | 普通株式 | 購入 | 378 | $43.16 |
| 2020-02-29 | O'NEIL, PATRICK R. | SVP & General Counsel | 普通株式 | 購入 | 289 | $43.16 |
| 2020-02-29 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 314 | $43.16 |
| 2020-02-29 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 147 | $43.16 |
| 2020-02-29 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 378 | $43.16 |
| 2020-02-29 | BENNETT, C FRANK | Chief Scientific Officer | 普通株式 | 購入 | 169 | $43.16 |
| 2020-02-10 | O'NEIL, PATRICK R. | SVP & General Counsel | 普通株式 | 売却 | 3,882 | $59.60 |
| 2020-01-15 | CROOKE, STANLEY T | Director, Executive Chairman of Board | 譲渡制限付株式ユニット | 購入 | 62,982 | $0.00 |
| 2020-01-15 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 3,905 | $62.06 |
| 2020-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 13,139 | $0.00 |
| 2020-01-15 | SWAYZE, ERIC | SVP, Research | 普通株式 | 購入 | 6,522 | $0.00 |
| 2020-01-15 | SWAYZE, ERIC | SVP, Research | 普通株式 | 売却 | 2,367 | $62.06 |
| 2020-01-15 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 15,136 | $0.00 |
| 2020-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 4,277 | $62.06 |
| 2020-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 購入 | 24,205 | $0.00 |
| 2020-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 7,563 | $62.06 |
| 2020-01-15 | CROOKE, STANLEY T | Director, Executive Chairman of Board | 普通株式 | 購入 | 39,643 | $0.00 |
| 2020-01-15 | CROOKE, STANLEY T | Director, Executive Chairman of Board | 普通株式 | 売却 | 17,342 | $62.06 |
| 2020-01-15 | CROOKE, STANLEY T | Director, Executive Chairman of Board | 普通株式 | 購入 | 3,317 | $0.00 |
| 2020-01-15 | CROOKE, STANLEY T | Director, Executive Chairman of Board | 普通株式 | 売却 | 1,268 | $62.06 |
| 2020-01-15 | CROOKE, STANLEY T | Director, Executive Chairman of Board | 譲渡制限付株式ユニット | 購入 | 5,545 | $0.00 |
| 2020-01-15 | CROOKE, STANLEY T | Director, Executive Chairman of Board | 譲渡制限付株式ユニット | 売却 | 39,643 | $0.00 |
| 2020-01-15 | CROOKE, STANLEY T | Director, Executive Chairman of Board | 譲渡制限付株式ユニット | 売却 | 3,317 | $0.00 |
| 2020-01-15 | CADORET-MANIER, ONAIZA | Chief Corp Dev and Cml Officer | 譲渡制限付株式ユニット | 購入 | 22,667 | $0.00 |
| 2020-01-15 | BENNETT, C FRANK | Chief Scientific Officer | 普通株式 | 購入 | 11,711 | $0.00 |
| 2020-01-15 | BENNETT, C FRANK | Chief Scientific Officer | 普通株式 | 売却 | 4,162 | $62.06 |
| 2020-01-15 | BENNETT, C FRANK | Chief Scientific Officer | 譲渡制限付株式ユニット | 購入 | 21,612 | $0.00 |
| 2020-01-15 | BENNETT, C FRANK | Chief Scientific Officer | 譲渡制限付株式ユニット | 売却 | 11,711 | $0.00 |
| 2020-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 24,205 | $0.00 |
| 2020-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 4,654 | $62.06 |
| 2020-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 13,139 | $0.00 |
| 2020-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 12,044 | $0.00 |
| 2020-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 26,800 | $0.00 |
| 2020-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 4,277 | $62.06 |
| 2020-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 12,044 | $0.00 |
| 2020-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 売却 | 19,921 | $0.00 |
| 2020-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 購入 | 17,009 | $0.00 |
| 2020-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 譲渡制限付株式ユニット | 購入 | 65,979 | $0.00 |
| 2020-01-15 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 購入 | 19,921 | $0.00 |
| 2020-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 12,045 | $0.00 |
| 2020-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 12,045 | $0.00 |
| 2020-01-15 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 15,136 | $0.00 |
| 2020-01-15 | SWAYZE, ERIC | SVP, Research | 譲渡制限付株式ユニット | 売却 | 6,522 | $0.00 |
| 2020-01-15 | SWAYZE, ERIC | SVP, Research | 譲渡制限付株式ユニット | 購入 | 12,235 | $0.00 |
| 2020-01-09 | CADORET-MANIER, ONAIZA | Chief Corp Development Officer | ストックオプション | 購入 | 51,000 | $0.00 |
| 2020-01-02 | CROOKE, STANLEY T | Director, Executive Chairman of Board | ストックオプション | 購入 | 141,709 | $0.00 |
| 2020-01-02 | CROOKE, STANLEY T | Director, Executive Chairman of Board | ストックオプション | 購入 | 12,477 | $0.00 |
| 2020-01-02 | BENNETT, C FRANK | Chief Scientific Officer | ストックオプション | 購入 | 48,626 | $0.00 |
| 2020-01-02 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 購入 | 60,299 | $0.00 |
| 2020-01-02 | MONIA, BRETT P | Director, Chief Executive Officer | 普通株式 | 売却 | 173 | $60.25 |
| 2020-01-02 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 購入 | 158,659 | $0.00 |
| 2020-01-02 | GEARY, RICHARD S | SVP, Development | ストックオプション | 購入 | 54,461 | $0.00 |
| 2020-01-02 | MONIA, BRETT P | Director, Chief Executive Officer | ストックオプション | 購入 | 148,454 | $0.00 |
| 2020-01-02 | SWAYZE, ERIC | SVP, Research | ストックオプション | 購入 | 27,528 | $0.00 |
| 2020-01-02 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 購入 | 54,461 | $0.00 |
| 2019-12-23 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 1,000 | $61.87 |
| 2019-12-23 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 1,000 | $0.00 |
| 2019-12-23 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 1,000 | $35.53 |
| 2019-12-20 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 3,438 | $0.00 |
| 2019-12-20 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 7,196 | $0.00 |
| 2019-12-20 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 2,014 | $61.52 |
| 2019-12-20 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 3,438 | $10.82 |
| 2019-12-20 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 4,215 | $61.52 |
| 2019-12-20 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 7,196 | $10.82 |
| 2019-12-17 | IONIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 購入 | 6,873,344 | $ |
| 2019-12-16 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 1,000 | $65.45 |
| 2019-12-16 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 1,000 | $35.53 |
| 2019-12-16 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 1,000 | $0.00 |
| 2019-12-09 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 1,000 | $63.74 |
| 2019-12-09 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 1,000 | $35.53 |
| 2019-12-09 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 1,000 | $0.00 |
| 2019-12-04 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 10,000 | $65.00 |
| 2019-12-04 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 4,062 | $0.00 |
| 2019-12-04 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 504 | $0.00 |
| 2019-12-04 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 4,062 | $65.00 |
| 2019-12-04 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 4,062 | $10.82 |
| 2019-12-04 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 504 | $65.00 |
| 2019-12-04 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 504 | $10.82 |
| 2019-12-04 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 10,000 | $0.00 |
| 2019-12-04 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 10,000 | $14.69 |
| 2019-12-02 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 1,000 | $0.00 |
| 2019-12-02 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 5,000 | $0.00 |
| 2019-12-02 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 5,000 | $65.06 |
| 2019-12-02 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 5,000 | $14.69 |
| 2019-12-02 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 1,000 | $64.08 |
| 2019-12-02 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 1,000 | $35.53 |
| 2019-11-25 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 4,000 | $62.50 |
| 2019-11-25 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 4,000 | $0.00 |
| 2019-11-25 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 812 | $62.90 |
| 2019-11-25 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 4,000 | $10.82 |
| 2019-11-20 | MONIA, BRETT P | Director, COO & SVP, Translational Med | 普通株式 | 売却 | 5,776 | $60.01 |
| 2019-11-20 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 2,000 | $60.00 |
| 2019-11-19 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 4,000 | $10.82 |
| 2019-11-19 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 4,000 | $0.00 |
| 2019-11-19 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 4,000 | $58.80 |
| 2019-10-15 | REIKES, PETER N | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2019-10-15 | REIKES, PETER N | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2019-10-15 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 売却 | 1,778 | $0.00 |
| 2019-10-15 | HAYDEN, MICHAEL R | Director | 普通株式 | 購入 | 1,778 | $0.00 |
| 2019-08-21 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2019-08-21 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $39.87 |
| 2019-08-21 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $72.15 |
| 2019-08-20 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2019-08-20 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $39.87 |
| 2019-08-20 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $71.00 |
| 2019-08-20 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 2,000 | $39.87 |
| 2019-08-20 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 2,000 | $71.00 |
| 2019-08-20 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 2,000 | $0.00 |
| 2019-07-18 | CROOKE, STANLEY T | Director, Chairman & CEO | 普通株式 | 購入 | 10,000 | $39.87 |
| 2019-07-18 | CROOKE, STANLEY T | Director, Chairman & CEO | 普通株式 | 売却 | 10,000 | $70.25 |
| 2019-07-18 | CROOKE, STANLEY T | Director, Chairman & CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2019-07-15 | MCDEVITT, DAMIEN | Chief Business Officer | 普通株式 | 売却 | 1,225 | $67.86 |
| 2019-07-15 | MCDEVITT, DAMIEN | Chief Business Officer | 譲渡制限付株式ユニット | 売却 | 3,542 | $0.00 |
| 2019-07-15 | MCDEVITT, DAMIEN | Chief Business Officer | 普通株式 | 購入 | 3,542 | $0.00 |
| 2019-07-03 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2019-07-03 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2019-07-03 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2019-07-03 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2019-07-03 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2019-07-03 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2019-07-03 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2019-07-03 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2019-07-03 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2019-07-03 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2019-07-03 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2019-07-03 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2019-07-02 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2019-07-02 | MONIA, BRETT P | Director, Chief Operating Officer | 普通株式 | 売却 | 210 | $66.40 |
| 2019-07-02 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2019-07-02 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2019-07-02 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2019-07-02 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2019-07-02 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2019-07-02 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2019-07-02 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2019-07-02 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2019-07-02 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2019-07-02 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2019-07-02 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 889 | $0.00 |
| 2019-07-02 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2019-07-02 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 889 | $0.00 |
| 2019-07-01 | HERMAN, JOAN E | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2019-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2019-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2019-07-01 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 購入 | 7,110 | $0.00 |
| 2019-07-01 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2019-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2019-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2019-07-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 118 | $45.70 |
| 2019-07-01 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2019-07-01 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2019-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 購入 | 7,110 | $0.00 |
| 2019-07-01 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2019-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2019-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2019-07-01 | REIKES, PETER N | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2019-07-01 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2019-07-01 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2019-07-01 | PARSHALL, B LYNNE | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2019-07-01 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 購入 | 7,110 | $0.00 |
| 2019-07-01 | REIKES, PETER N | Director | 譲渡制限付株式ユニット | 購入 | 7,110 | $0.00 |
| 2019-07-01 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2019-07-01 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 141 | $45.70 |
| 2019-07-01 | HOUGEN, ELIZABETH L | SVP Finance & CFO | 普通株式 | 購入 | 105 | $45.70 |
| 2019-07-01 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2019-07-01 | MONIA, BRETT P | Director, Chief Operating Officer | 普通株式 | 購入 | 173 | $45.70 |
| 2019-07-01 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 161 | $45.70 |
| 2019-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2019-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 購入 | 7,110 | $0.00 |
| 2019-07-01 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2019-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2019-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2019-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 購入 | 7,110 | $0.00 |
| 2019-07-01 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2019-07-01 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2019-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2019-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 購入 | 7,110 | $0.00 |
| 2019-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2019-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2019-07-01 | CASTLEMAN, BREAUX | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2019-07-01 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2019-07-01 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 666 | $0.00 |
| 2019-07-01 | LOSCALZO, JOSEPH | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2019-07-01 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 購入 | 7,110 | $0.00 |
| 2019-07-01 | MCDEVITT, DAMIEN | Chief Business Officer | 普通株式 | 購入 | 256 | $45.70 |
| 2019-07-01 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 購入 | 7,110 | $0.00 |
| 2019-07-01 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2019-07-01 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 666 | $0.00 |
| 2019-07-01 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2019-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 購入 | 7,110 | $0.00 |
| 2019-07-01 | HAYDEN, MICHAEL R | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2019-06-24 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 9,690 | $16.32 |
| 2019-06-24 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 5,310 | $16.32 |
| 2019-06-24 | BERTHELSEN, SPENCER R | Director | ストックオプション | 売却 | 15,000 | $0.00 |
| 2019-06-24 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 9,690 | $63.84 |
| 2019-06-24 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 5,310 | $63.37 |
| 2019-06-10 | HERMAN, JOAN E | Director | ストックオプション | 購入 | 32,000 | $0.00 |
| 2019-06-10 | HERMAN, JOAN E | Director | 譲渡制限付株式ユニット | 購入 | 14,221 | $0.00 |
| 2019-06-04 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 15,000 | $16.32 |
| 2019-06-04 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2019-06-04 | MUTO, FREDERICK T | Director | 普通株式 | 売却 | 15,000 | $65.29 |
| 2019-05-06 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 8,000 | $0.00 |
| 2019-05-06 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 8,000 | $24.42 |
| 2019-05-06 | MUTO, FREDERICK T | Director | 普通株式 | 売却 | 8,000 | $72.75 |
| 2019-04-29 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 50,000 | $75.01 |
| 2019-04-29 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 50,000 | $39.87 |
| 2019-04-29 | PARSHALL, B LYNNE | Director | ストックオプション | 購入 | 50,000 | $0.00 |
| 2019-04-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 6,680 | $14.69 |
| 2019-04-16 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 6,680 | $0.00 |
| 2019-04-16 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 13,320 | $0.00 |
| 2019-04-16 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 300 | $0.00 |
| 2019-04-16 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 700 | $0.00 |
| 2019-04-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 700 | $84.75 |
| 2019-04-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 700 | $39.87 |
| 2019-04-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 300 | $84.75 |
| 2019-04-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 300 | $10.82 |
| 2019-04-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 13,320 | $84.56 |
| 2019-04-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 13,320 | $39.87 |
| 2019-04-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 6,680 | $84.75 |
| 2019-04-15 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2019-04-15 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2019-04-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $85.25 |
| 2019-04-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,000 | $10.82 |
| 2019-04-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $85.25 |
| 2019-04-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $14.69 |
| 2019-04-08 | GEARY, RICHARD S | SVP, Development | ストックオプション | 購入 | 24,000 | $0.00 |
| 2019-04-08 | GEARY, RICHARD S | SVP, Development | ストックオプション | 購入 | 2,240 | $0.00 |
| 2019-04-08 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 2,240 | $84.00 |
| 2019-04-08 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 20,000 | $39.87 |
| 2019-04-08 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 20,000 | $84.00 |
| 2019-04-08 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 24,000 | $47.34 |
| 2019-04-08 | GEARY, RICHARD S | SVP, Development | ストックオプション | 購入 | 20,000 | $0.00 |
| 2019-04-08 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 24,000 | $84.02 |
| 2019-04-08 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 2,240 | $14.69 |
| 2019-04-05 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 2,252 | $84.75 |
| 2019-04-05 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 2,252 | $61.68 |
| 2019-04-05 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 購入 | 2,252 | $0.00 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 3,600 | $82.10 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 8,000 | $49.25 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 8,000 | $84.29 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 1,122 | $82.01 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 1,878 | $84.25 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 購入 | 20,365 | $0.00 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 購入 | 2,657 | $0.00 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 購入 | 5,600 | $0.00 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 購入 | 8,000 | $0.00 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 15,492 | $84.75 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 15,492 | $61.68 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 4,873 | $61.68 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 4,873 | $82.19 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 2,657 | $61.57 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 2,657 | $82.03 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 2,000 | $47.34 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 2,000 | $84.20 |
| 2019-04-04 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 3,600 | $47.34 |
| 2019-04-03 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 7,654 | $61.68 |
| 2019-04-03 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 7,654 | $84.83 |
| 2019-04-03 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 購入 | 7,654 | $0.00 |
| 2019-03-29 | IONIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 購入 | 2,837,373 | $ |
| 2019-03-19 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 10,000 | $79.63 |
| 2019-03-18 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 購入 | 28,800 | $0.00 |
| 2019-03-18 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 28,800 | $61.57 |
| 2019-03-18 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 28,800 | $78.79 |
| 2019-03-12 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 8,334 | $75.00 |
| 2019-03-12 | PARSHALL, B LYNNE | Director | ストックオプション | 購入 | 8,334 | $0.00 |
| 2019-03-12 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 8,334 | $39.87 |
| 2019-02-27 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 8,000 | $68.75 |
| 2019-02-27 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 購入 | 8,000 | $0.00 |
| 2019-02-27 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 14,100 | $47.34 |
| 2019-02-27 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 4,700 | $64.51 |
| 2019-02-27 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 4,700 | $47.34 |
| 2019-02-27 | PARSHALL, B LYNNE | Director | ストックオプション | 購入 | 8,333 | $0.00 |
| 2019-02-27 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 8,333 | $70.00 |
| 2019-02-27 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 8,333 | $39.87 |
| 2019-02-27 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 14,100 | $68.75 |
| 2019-02-27 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 8,000 | $39.87 |
| 2019-02-27 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 購入 | 18,800 | $0.00 |
| 2019-02-26 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 37,000 | $61.54 |
| 2019-02-26 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 37,000 | $39.87 |
| 2019-02-26 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 37,000 | $0.00 |
| 2019-02-25 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 40,000 | $0.00 |
| 2019-02-25 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 40,000 | $60.07 |
| 2019-02-25 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 40,000 | $39.87 |
| 2019-02-13 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,604 | $60.00 |
| 2019-02-13 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 40,000 | $0.00 |
| 2019-02-13 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 40,000 | $60.10 |
| 2019-02-13 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,300 | $39.87 |
| 2019-02-13 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,300 | $60.00 |
| 2019-02-13 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,604 | $0.00 |
| 2019-02-13 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 5,300 | $0.00 |
| 2019-02-13 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 999 | $60.00 |
| 2019-02-13 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,604 | $10.82 |
| 2019-02-13 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 40,000 | $39.87 |
| 2019-02-12 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 購入 | 275 | $0.00 |
| 2019-02-12 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 275 | $59.50 |
| 2019-02-12 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 275 | $39.87 |
| 2019-02-05 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 15,600 | $39.87 |
| 2019-02-05 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 15,600 | $59.50 |
| 2019-02-05 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 購入 | 15,600 | $0.00 |
| 2019-02-01 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 購入 | 4,000 | $0.00 |
| 2019-02-01 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 購入 | 9,013 | $0.00 |
| 2019-02-01 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 4,000 | $58.29 |
| 2019-02-01 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 4,000 | $39.87 |
| 2019-02-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 9,013 | $14.69 |
| 2019-02-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 9,013 | $58.29 |
| 2019-01-15 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 20,656 | $0.00 |
| 2019-01-15 | HOUGEN, ELIZABETH L | SVP Finance & CFO | 普通株式 | 購入 | 7,891 | $0.00 |
| 2019-01-15 | HOUGEN, ELIZABETH L | SVP Finance & CFO | 普通株式 | 売却 | 2,842 | $58.26 |
| 2019-01-15 | MONIA, BRETT P | Chief Operating Officer | 普通株式 | 購入 | 10,006 | $0.00 |
| 2019-01-15 | MONIA, BRETT P | Chief Operating Officer | 普通株式 | 売却 | 3,572 | $58.26 |
| 2019-01-15 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 20,656 | $0.00 |
| 2019-01-15 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 6,159 | $58.26 |
| 2019-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 7,822 | $0.00 |
| 2019-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 2,818 | $58.26 |
| 2019-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 購入 | 20,797 | $0.00 |
| 2019-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 7,822 | $0.00 |
| 2019-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 8,085 | $0.00 |
| 2019-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 2,908 | $58.26 |
| 2019-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 購入 | 25,730 | $0.00 |
| 2019-01-15 | HOUGEN, ELIZABETH L | SVP Finance & CFO | 譲渡制限付株式ユニット | 購入 | 22,131 | $0.00 |
| 2019-01-15 | HOUGEN, ELIZABETH L | SVP Finance & CFO | 譲渡制限付株式ユニット | 売却 | 7,891 | $0.00 |
| 2019-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 2,346 | $0.00 |
| 2019-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 30,587 | $0.00 |
| 2019-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 購入 | 5,332 | $0.00 |
| 2019-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 購入 | 63,726 | $0.00 |
| 2019-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 942 | $58.26 |
| 2019-01-15 | MONIA, BRETT P | Chief Operating Officer | 譲渡制限付株式ユニット | 購入 | 45,728 | $0.00 |
| 2019-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 2,346 | $0.00 |
| 2019-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 12,686 | $58.26 |
| 2019-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 30,587 | $0.00 |
| 2019-01-15 | MONIA, BRETT P | Chief Operating Officer | 譲渡制限付株式ユニット | 売却 | 10,006 | $0.00 |
| 2019-01-15 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 譲渡制限付株式ユニット | 購入 | 22,131 | $0.00 |
| 2019-01-15 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 7,823 | $0.00 |
| 2019-01-15 | MCDEVITT, DAMIEN | Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 13,065 | $0.00 |
| 2019-01-15 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 2,734 | $58.26 |
| 2019-01-15 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 7,823 | $0.00 |
| 2019-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 8,085 | $0.00 |
| 2019-01-03 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 売却 | 400 | $0.00 |
| 2019-01-03 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 4,000 | $39.87 |
| 2019-01-03 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 売却 | 4,000 | $0.00 |
| 2019-01-03 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 4,000 | $54.80 |
| 2019-01-03 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 400 | $54.80 |
| 2019-01-03 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 400 | $10.82 |
| 2019-01-02 | MCDEVITT, DAMIEN | Chief Business Officer | ストックオプション | 購入 | 29,400 | $0.00 |
| 2019-01-02 | HOUGEN, ELIZABETH L | SVP Finance & CFO | ストックオプション | 購入 | 49,800 | $0.00 |
| 2019-01-02 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 購入 | 46,800 | $0.00 |
| 2019-01-02 | MONIA, BRETT P | Chief Operating Officer | ストックオプション | 購入 | 102,900 | $0.00 |
| 2019-01-02 | GEARY, RICHARD S | SVP, Development | ストックオプション | 購入 | 57,900 | $0.00 |
| 2019-01-02 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 購入 | 143,400 | $0.00 |
| 2019-01-02 | MONIA, BRETT P | Chief Operating Officer | 普通株式 | 売却 | 214 | $53.50 |
| 2019-01-02 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 購入 | 12,000 | $0.00 |
| 2019-01-02 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 購入 | 49,800 | $0.00 |
| 2019-01-01 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 66 | $36.45 |
| 2019-01-01 | HOUGEN, ELIZABETH L | SVP Finance & CFO | 普通株式 | 購入 | 127 | $36.45 |
| 2019-01-01 | MONIA, BRETT P | Chief Operating Officer | 普通株式 | 購入 | 210 | $36.45 |
| 2019-01-01 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 407 | $36.45 |
| 2019-01-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 128 | $36.45 |
| 2018-12-19 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 購入 | 2,063 | $0.00 |
| 2018-12-19 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 2,063 | $7.25 |
| 2018-12-19 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 2,063 | $52.05 |
| 2018-12-18 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 購入 | 2,000 | $0.00 |
| 2018-12-18 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 2,000 | $52.00 |
| 2018-12-18 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 2,000 | $7.25 |
| 2018-11-23 | MONIA, BRETT P | Chief Operating Officer | ストックオプション | 購入 | 34,000 | $0.00 |
| 2018-11-23 | MONIA, BRETT P | Chief Operating Officer | 普通株式 | 売却 | 34,000 | $55.00 |
| 2018-11-23 | MONIA, BRETT P | Chief Operating Officer | 普通株式 | 購入 | 34,000 | $14.69 |
| 2018-11-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 12,500 | $49.54 |
| 2018-11-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 12,500 | $14.69 |
| 2018-11-01 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 購入 | 12,500 | $0.00 |
| 2018-10-17 | IONIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 購入 | 1,671,849 | $ |
| 2018-10-15 | HAYDEN, MICHAEL R | Director | 譲渡制限付株式ユニット | 購入 | 7,110 | $0.00 |
| 2018-10-15 | REIKES, PETER N | Director | 譲渡制限付株式ユニット | 購入 | 7,110 | $0.00 |
| 2018-09-23 | REIKES, PETER N | Director | ストックオプション | 購入 | 32,000 | $0.00 |
| 2018-09-20 | HAYDEN, MICHAEL R | Director | ストックオプション | 購入 | 32,000 | $0.00 |
| 2018-08-27 | MONIA, BRETT P | Chief Operating Officer | 普通株式 | 売却 | 8,993 | $54.00 |
| 2018-08-27 | MONIA, BRETT P | Chief Operating Officer | 普通株式 | 購入 | 7,500 | $7.21 |
| 2018-08-27 | MONIA, BRETT P | Chief Operating Officer | 普通株式 | 売却 | 7,500 | $54.00 |
| 2018-08-27 | MONIA, BRETT P | Chief Operating Officer | ストックオプション | 購入 | 8,993 | $0.00 |
| 2018-08-27 | MONIA, BRETT P | Chief Operating Officer | ストックオプション | 購入 | 7,500 | $0.00 |
| 2018-08-27 | MONIA, BRETT P | Chief Operating Officer | 普通株式 | 購入 | 8,993 | $7.25 |
| 2018-08-08 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 13 | $7.25 |
| 2018-08-08 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 13 | $45.00 |
| 2018-08-08 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 購入 | 13 | $0.00 |
| 2018-08-08 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 12,487 | $45.00 |
| 2018-08-08 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 購入 | 12,487 | $0.00 |
| 2018-08-08 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 12,487 | $14.69 |
| 2018-08-03 | IONIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 購入 | 1,597,571 | $ |
| 2018-07-24 | MONIA, BRETT P | Chief Operating Officer | 普通株式 | 売却 | 156 | $47.03 |
| 2018-07-17 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 15,000 | $0.00 |
| 2018-07-17 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 15,000 | $9.30 |
| 2018-07-17 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 15,000 | $9.22 |
| 2018-07-15 | MCDEVITT, DAMIEN | Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 14,167 | $0.00 |
| 2018-07-03 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2018-07-03 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2018-07-03 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2018-07-03 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2018-07-03 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2018-07-03 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2018-07-03 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2018-07-03 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2018-07-03 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2018-07-03 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2018-07-03 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2018-07-03 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2018-07-02 | PARSHALL, B LYNNE | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2018-07-02 | LOSCALZO, JOSEPH | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2018-07-02 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 購入 | 3,555 | $0.00 |
| 2018-07-02 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2018-07-02 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 購入 | 3,555 | $0.00 |
| 2018-07-02 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 購入 | 3,555 | $0.00 |
| 2018-07-02 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 購入 | 3,555 | $0.00 |
| 2018-07-02 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 購入 | 3,555 | $0.00 |
| 2018-07-02 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2018-07-02 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2018-07-02 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 購入 | 3,555 | $0.00 |
| 2018-07-02 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 購入 | 3,555 | $0.00 |
| 2018-07-02 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2018-07-02 | CASTLEMAN, BREAUX | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2018-07-01 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 2,000 | $0.00 |
| 2018-07-01 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 177 | $35.42 |
| 2018-07-01 | HOUGEN, ELIZABETH L | SVP Finance & CFO | 普通株式 | 購入 | 274 | $35.42 |
| 2018-07-01 | MONIA, BRETT P | Chief Operating Officer | 普通株式 | 購入 | 214 | $35.42 |
| 2018-07-01 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 66 | $35.42 |
| 2018-07-01 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 2,000 | $0.00 |
| 2018-07-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 282 | $35.42 |
| 2018-07-01 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 2,000 | $0.00 |
| 2018-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 2,000 | $0.00 |
| 2018-07-01 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 2,000 | $0.00 |
| 2018-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 2,000 | $0.00 |
| 2018-07-01 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 2,000 | $0.00 |
| 2018-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 2,000 | $0.00 |
| 2018-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 2,000 | $0.00 |
| 2018-07-01 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,000 | $0.00 |
| 2018-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 2,000 | $0.00 |
| 2018-07-01 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 2,000 | $0.00 |
| 2018-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 5,700 | $13.88 |
| 2018-06-25 | BERTHELSEN, SPENCER R | Director | ストックオプション | 売却 | 15,000 | $0.00 |
| 2018-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 9,300 | $13.88 |
| 2018-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 5,700 | $42.03 |
| 2018-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 9,300 | $42.47 |
| 2018-06-18 | MCDEVITT, DAMIEN | Chief Business Officer | ストックオプション | 購入 | 63,750 | $0.00 |
| 2018-05-31 | MUTO, FREDERICK T | Director | 普通株式 | 売却 | 15,000 | $46.45 |
| 2018-05-31 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 15,000 | $13.88 |
| 2018-05-31 | MUTO, FREDERICK T | Director | ストックオプション | 売却 | 15,000 | $0.00 |
| 2018-05-11 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 8,590 | $13.88 |
| 2018-05-11 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 400 | $13.88 |
| 2018-05-11 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 15,000 | $0.00 |
| 2018-05-11 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 12,500 | $45.00 |
| 2018-05-11 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 12,500 | $7.25 |
| 2018-05-11 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 6,010 | $13.88 |
| 2018-05-11 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 400 | $44.02 |
| 2018-05-11 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 6,010 | $45.79 |
| 2018-05-11 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 8,590 | $45.03 |
| 2018-05-11 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 購入 | 12,500 | $0.00 |
| 2018-04-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 4,981 | $44.50 |
| 2018-04-17 | IONIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 購入 | 8,000,000 | $ |
| 2018-04-17 | IONIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 購入 | 10,666,666 | $18.75 |
| 2018-04-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 4,981 | $14.69 |
| 2018-04-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 4,981 | $44.30 |
| 2018-04-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 2,000 | $10.82 |
| 2018-04-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 2,000 | $44.30 |
| 2018-04-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 2,000 | $44.50 |
| 2018-04-17 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 9,962 | $0.00 |
| 2018-04-17 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 4,000 | $0.00 |
| 2018-03-29 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 2,000 | $0.00 |
| 2018-03-29 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,000 | $24.42 |
| 2018-03-29 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 2,000 | $46.15 |
| 2018-03-15 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 900 | $51.59 |
| 2018-03-15 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 200 | $24.42 |
| 2018-03-15 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 2,000 | $0.00 |
| 2018-03-15 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 200 | $52.11 |
| 2018-03-15 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 900 | $24.42 |
| 2018-03-15 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 900 | $50.45 |
| 2018-03-12 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 1,000 | $55.00 |
| 2018-03-12 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 1,000 | $10.82 |
| 2018-03-12 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 売却 | 1,000 | $0.00 |
| 2018-02-28 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 3,000 | $0.00 |
| 2018-02-28 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 900 | $35.53 |
| 2018-02-28 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 900 | $51.02 |
| 2018-02-28 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,100 | $35.53 |
| 2018-02-28 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 2,100 | $52.29 |
| 2018-02-15 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 1,600 | $49.20 |
| 2018-02-15 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 1,400 | $35.53 |
| 2018-02-15 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 1,400 | $48.76 |
| 2018-02-15 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 1,600 | $35.53 |
| 2018-02-15 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 3,000 | $0.00 |
| 2018-02-03 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 937 | $0.00 |
| 2018-02-03 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 937 | $0.00 |
| 2018-02-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 12,500 | $52.50 |
| 2018-02-01 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 購入 | 12,500 | $0.00 |
| 2018-02-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 12,500 | $7.25 |
| 2018-01-30 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 3,000 | $35.53 |
| 2018-01-30 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 3,000 | $52.86 |
| 2018-01-30 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 3,000 | $0.00 |
| 2018-01-29 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2018-01-29 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $54.12 |
| 2018-01-29 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2018-01-29 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 55 | $10.82 |
| 2018-01-29 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 55 | $55.00 |
| 2018-01-29 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 300 | $10.82 |
| 2018-01-29 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 売却 | 300 | $0.00 |
| 2018-01-29 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 300 | $55.00 |
| 2018-01-29 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 売却 | 55 | $0.00 |
| 2018-01-29 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $14.69 |
| 2018-01-29 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $54.12 |
| 2018-01-29 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,000 | $10.82 |
| 2018-01-25 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 購入 | 645 | $10.82 |
| 2018-01-25 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | ストックオプション | 売却 | 645 | $0.00 |
| 2018-01-25 | O'NEIL, PATRICK R. | SVP Legal & General Counsel | 普通株式 | 売却 | 645 | $55.00 |
| 2018-01-16 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 1,600 | $35.53 |
| 2018-01-16 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 2,724 | $51.76 |
| 2018-01-16 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 2,697 | $51.76 |
| 2018-01-16 | BOYCE, SARAH | Chief Business Officer | 普通株式 | 売却 | 2,196 | $51.76 |
| 2018-01-16 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 2,696 | $51.76 |
| 2018-01-16 | MONIA, BRETT P | COO | 普通株式 | 売却 | 2,821 | $51.76 |
| 2018-01-16 | PARSHALL, B LYNNE | Director | 普通株式 | 売却 | 5,986 | $51.76 |
| 2018-01-16 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 2,723 | $51.76 |
| 2018-01-16 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 3,000 | $0.00 |
| 2018-01-16 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 1,400 | $52.97 |
| 2018-01-16 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 1,400 | $35.53 |
| 2018-01-16 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 1,600 | $52.13 |
| 2018-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 6,663 | $0.00 |
| 2018-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 購入 | 12,916 | $0.00 |
| 2018-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 6,732 | $0.00 |
| 2018-01-15 | PARSHALL, B LYNNE | Director | 普通株式 | 購入 | 18,339 | $0.00 |
| 2018-01-15 | BOYCE, SARAH | Chief Business Officer | 普通株式 | 購入 | 5,367 | $0.00 |
| 2018-01-15 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 購入 | 23,016 | $0.00 |
| 2018-01-15 | PARSHALL, B LYNNE | Director | 譲渡制限付株式ユニット | 売却 | 18,339 | $0.00 |
| 2018-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 29,612 | $0.00 |
| 2018-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 6,663 | $0.00 |
| 2018-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 6,732 | $0.00 |
| 2018-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 656 | $51.76 |
| 2018-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 6,732 | $0.00 |
| 2018-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 購入 | 35,149 | $0.00 |
| 2018-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 購入 | 3,911 | $0.00 |
| 2018-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 購入 | 12,141 | $0.00 |
| 2018-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 6,732 | $0.00 |
| 2018-01-15 | MONIA, BRETT P | COO | 譲渡制限付株式ユニット | 売却 | 6,985 | $0.00 |
| 2018-01-15 | MONIA, BRETT P | COO | 譲渡制限付株式ユニット | 購入 | 6,667 | $0.00 |
| 2018-01-15 | MONIA, BRETT P | COO | 譲渡制限付株式ユニット | 購入 | 12,916 | $0.00 |
| 2018-01-15 | BOYCE, SARAH | Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 12,916 | $0.00 |
| 2018-01-15 | MONIA, BRETT P | COO | 普通株式 | 購入 | 6,985 | $0.00 |
| 2018-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 1,722 | $0.00 |
| 2018-01-15 | BOYCE, SARAH | Chief Business Officer | 譲渡制限付株式ユニット | 売却 | 5,367 | $0.00 |
| 2018-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 6,663 | $0.00 |
| 2018-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 購入 | 12,137 | $0.00 |
| 2018-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 6,663 | $0.00 |
| 2018-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 29,612 | $0.00 |
| 2018-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 15,893 | $51.76 |
| 2018-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,722 | $0.00 |
| 2018-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 12,137 | $0.00 |
| 2018-01-14 | MONIA, BRETT P | COO | ストックオプション | 購入 | 30,000 | $0.00 |
| 2018-01-08 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2018-01-08 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2018-01-08 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $14.69 |
| 2018-01-08 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,000 | $10.82 |
| 2018-01-08 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $52.01 |
| 2018-01-08 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $52.01 |
| 2018-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 904 | $49.71 |
| 2018-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 20,000 | $14.69 |
| 2018-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 20,000 | $50.02 |
| 2018-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 904 | $7.25 |
| 2018-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,096 | $10.82 |
| 2018-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,096 | $50.02 |
| 2018-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2018-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 904 | $0.00 |
| 2018-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,096 | $0.00 |
| 2018-01-02 | BOYCE, SARAH | Chief Business Officer | ストックオプション | 購入 | 58,125 | $0.00 |
| 2018-01-02 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 購入 | 54,619 | $0.00 |
| 2018-01-02 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 購入 | 103,575 | $0.00 |
| 2018-01-02 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 購入 | 54,638 | $0.00 |
| 2018-01-02 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 163 | $50.00 |
| 2018-01-02 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 購入 | 58,125 | $0.00 |
| 2018-01-02 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 購入 | 54,619 | $0.00 |
| 2018-01-02 | GEARY, RICHARD S | SVP, Development | ストックオプション | 購入 | 58,125 | $0.00 |
| 2018-01-02 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 購入 | 158,175 | $0.00 |
| 2018-01-02 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 購入 | 17,603 | $0.00 |
| 2018-01-01 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 86 | $42.76 |
| 2018-01-01 | BOYCE, SARAH | Chief Business Officer | 普通株式 | 購入 | 491 | $42.76 |
| 2018-01-01 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 320 | $42.76 |
| 2018-01-01 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 100 | $42.76 |
| 2018-01-01 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 156 | $42.76 |
| 2018-01-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 53 | $42.76 |
| 2018-01-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 106 | $42.76 |
| 2017-12-29 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 3,000 | $50.56 |
| 2017-12-29 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 3,000 | $28.47 |
| 2017-12-29 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 3,000 | $0.00 |
| 2017-12-15 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 3,000 | $28.47 |
| 2017-12-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 5,000 | $52.55 |
| 2017-12-15 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 3,000 | $0.00 |
| 2017-12-15 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 3,000 | $51.69 |
| 2017-12-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 5,000 | $10.29 |
| 2017-12-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 5,000 | $0.00 |
| 2017-12-04 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 4,000 | $57.00 |
| 2017-12-04 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 4,000 | $10.29 |
| 2017-12-04 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 4,000 | $0.00 |
| 2017-12-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,000 | $10.82 |
| 2017-12-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,000 | $0.00 |
| 2017-12-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,000 | $55.50 |
| 2017-11-30 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 3,000 | $53.55 |
| 2017-11-30 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 3,000 | $28.47 |
| 2017-11-30 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 3,000 | $0.00 |
| 2017-11-29 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 6,000 | $0.00 |
| 2017-11-29 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 6,000 | $10.29 |
| 2017-11-29 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 6,000 | $53.02 |
| 2017-11-16 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 7,000 | $0.00 |
| 2017-11-16 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 2,812 | $0.00 |
| 2017-11-16 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 7,000 | $10.29 |
| 2017-11-16 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 7,000 | $54.35 |
| 2017-11-16 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,812 | $12.94 |
| 2017-11-15 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,250 | $28.47 |
| 2017-11-15 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 2,250 | $53.56 |
| 2017-11-15 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 2,250 | $0.00 |
| 2017-11-13 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 3,000 | $55.39 |
| 2017-11-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,000 | $58.35 |
| 2017-11-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,000 | $10.82 |
| 2017-11-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,000 | $0.00 |
| 2017-10-18 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 12,250 | $65.00 |
| 2017-10-18 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 7,785 | $14.69 |
| 2017-10-18 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 8,333 | $0.00 |
| 2017-10-18 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 7,785 | $0.00 |
| 2017-10-18 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 7,785 | $65.00 |
| 2017-10-18 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 12,250 | $10.29 |
| 2017-10-18 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 12,250 | $0.00 |
| 2017-10-18 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 8,333 | $39.87 |
| 2017-10-18 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 8,333 | $65.00 |
| 2017-10-13 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 15,000 | $59.46 |
| 2017-10-13 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 15,000 | $14.69 |
| 2017-10-13 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 807 | $60.00 |
| 2017-10-13 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 426 | $60.00 |
| 2017-10-13 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 7,035 | $7.25 |
| 2017-10-13 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 7,035 | $60.00 |
| 2017-10-13 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,500 | $0.00 |
| 2017-10-13 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 426 | $0.00 |
| 2017-10-13 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 7,035 | $0.00 |
| 2017-10-13 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,500 | $59.46 |
| 2017-10-13 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,500 | $7.25 |
| 2017-10-13 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 15,000 | $0.00 |
| 2017-10-13 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 426 | $10.29 |
| 2017-10-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 800 | $55.00 |
| 2017-10-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 800 | $10.82 |
| 2017-10-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 200 | $55.00 |
| 2017-10-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 200 | $7.25 |
| 2017-10-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 800 | $0.00 |
| 2017-10-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 200 | $0.00 |
| 2017-10-04 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $54.20 |
| 2017-10-04 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2017-10-04 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2017-10-04 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $54.25 |
| 2017-10-04 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 500 | $7.25 |
| 2017-10-04 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $54.25 |
| 2017-10-04 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $54.20 |
| 2017-10-04 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,000 | $14.69 |
| 2017-10-02 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $52.05 |
| 2017-10-02 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 500 | $7.25 |
| 2017-10-02 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $52.50 |
| 2017-10-02 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,500 | $0.00 |
| 2017-10-02 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $52.50 |
| 2017-10-02 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $52.05 |
| 2017-10-02 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,000 | $14.69 |
| 2017-10-02 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $51.45 |
| 2017-10-02 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $51.45 |
| 2017-10-02 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 15,000 | $0.00 |
| 2017-09-06 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 800 | $7.25 |
| 2017-09-06 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 800 | $55.00 |
| 2017-09-06 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 売却 | 800 | $0.00 |
| 2017-09-05 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 200 | $7.25 |
| 2017-09-05 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 200 | $55.00 |
| 2017-09-05 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 売却 | 200 | $0.00 |
| 2017-07-24 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 10,000 | $59.29 |
| 2017-07-24 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 10,000 | $10.29 |
| 2017-07-24 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 10,000 | $0.00 |
| 2017-07-20 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2017-07-20 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2017-07-20 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $55.35 |
| 2017-07-20 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $14.69 |
| 2017-07-20 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,000 | $7.25 |
| 2017-07-20 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $55.35 |
| 2017-07-19 | IONIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 購入 | 28,884,540 | $ |
| 2017-07-19 | IONIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 購入 | 3,125,000 | $8.00 |
| 2017-07-19 | IONIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 売却 | 28,884,540 | $0.00 |
| 2017-07-19 | IONIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 購入 | 13,438,339 | $ |
| 2017-07-17 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 15,000 | $0.00 |
| 2017-07-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,500 | $52.45 |
| 2017-07-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,500 | $7.25 |
| 2017-07-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 15,000 | $52.45 |
| 2017-07-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 15,000 | $14.69 |
| 2017-07-17 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,500 | $0.00 |
| 2017-07-03 | LOSCALZO, JOSEPH | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2017-07-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 13,462 | $52.08 |
| 2017-07-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 13,462 | $7.25 |
| 2017-07-03 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2017-07-03 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2017-07-03 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2017-07-03 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2017-07-03 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2017-07-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,538 | $14.69 |
| 2017-07-03 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2017-07-03 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2017-07-03 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2017-07-03 | CASTLEMAN, BREAUX | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2017-07-03 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2017-07-03 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2017-07-03 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 309 | $51.35 |
| 2017-07-03 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,500 | $0.00 |
| 2017-07-03 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,538 | $0.00 |
| 2017-07-03 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 13,462 | $0.00 |
| 2017-07-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,500 | $52.10 |
| 2017-07-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,500 | $7.25 |
| 2017-07-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,538 | $52.30 |
| 2017-07-02 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,469 | $0.00 |
| 2017-07-01 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 3,406 | $0.00 |
| 2017-07-01 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 90 | $40.66 |
| 2017-07-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 253 | $40.66 |
| 2017-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 2,469 | $0.00 |
| 2017-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 2,469 | $0.00 |
| 2017-07-01 | BOYCE, SARAH | Chief Business Officer | 普通株式 | 購入 | 17 | $40.66 |
| 2017-07-01 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 2,469 | $0.00 |
| 2017-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 2,469 | $0.00 |
| 2017-07-01 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 2,001 | $0.00 |
| 2017-07-01 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 2,001 | $0.00 |
| 2017-07-01 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 196 | $40.66 |
| 2017-07-01 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 104 | $40.66 |
| 2017-07-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 134 | $40.66 |
| 2017-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 3,406 | $0.00 |
| 2017-07-01 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 2,469 | $0.00 |
| 2017-07-01 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 163 | $40.66 |
| 2017-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 2,469 | $0.00 |
| 2017-07-01 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 2,469 | $0.00 |
| 2017-06-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 70 | $48.00 |
| 2017-06-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 70 | $0.00 |
| 2017-06-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 70 | $10.82 |
| 2017-05-31 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 12,500 | $9.77 |
| 2017-05-31 | MUTO, FREDERICK T | Director | ストックオプション | 売却 | 12,500 | $0.00 |
| 2017-05-31 | MUTO, FREDERICK T | Director | 普通株式 | 売却 | 12,500 | $45.22 |
| 2017-05-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 500 | $48.75 |
| 2017-05-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 500 | $10.82 |
| 2017-05-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 500 | $0.00 |
| 2017-05-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 150 | $48.75 |
| 2017-04-25 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,500 | $7.25 |
| 2017-04-25 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 15,000 | $47.81 |
| 2017-04-25 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 15,000 | $7.25 |
| 2017-04-25 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 15,000 | $0.00 |
| 2017-04-25 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,500 | $0.00 |
| 2017-04-25 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,500 | $47.81 |
| 2017-04-24 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 426 | $0.00 |
| 2017-04-24 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 74 | $45.00 |
| 2017-04-24 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 426 | $10.82 |
| 2017-04-24 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 426 | $45.00 |
| 2017-04-24 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 74 | $0.00 |
| 2017-04-24 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 74 | $10.82 |
| 2017-04-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $43.25 |
| 2017-04-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,000 | $7.25 |
| 2017-04-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $43.25 |
| 2017-04-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 500 | $7.25 |
| 2017-04-19 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 5,000 | $0.00 |
| 2017-04-19 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 500 | $0.00 |
| 2017-04-13 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 500 | $7.25 |
| 2017-04-13 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 500 | $0.00 |
| 2017-04-13 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $41.30 |
| 2017-04-13 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 500 | $10.29 |
| 2017-04-13 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $41.30 |
| 2017-04-13 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $7.25 |
| 2017-04-13 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2017-04-12 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,000 | $40.07 |
| 2017-04-12 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $40.07 |
| 2017-04-12 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2017-04-12 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2017-04-12 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $40.07 |
| 2017-04-12 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,000 | $10.29 |
| 2017-04-12 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $7.25 |
| 2017-03-03 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 5,000 | $10.29 |
| 2017-03-03 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 5,000 | $0.00 |
| 2017-03-03 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 5,000 | $55.00 |
| 2017-03-02 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,100 | $0.00 |
| 2017-03-02 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,100 | $51.05 |
| 2017-03-02 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 11,000 | $7.25 |
| 2017-03-02 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 11,000 | $0.00 |
| 2017-03-02 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 11,000 | $51.05 |
| 2017-03-02 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,100 | $10.29 |
| 2017-03-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 500 | $49.29 |
| 2017-03-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 500 | $0.00 |
| 2017-03-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,000 | $49.29 |
| 2017-03-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 500 | $10.82 |
| 2017-03-01 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 4,625 | $0.00 |
| 2017-03-01 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 4,625 | $49.26 |
| 2017-03-01 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 4,625 | $14.69 |
| 2017-02-24 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 12,500 | $9.77 |
| 2017-02-24 | BERTHELSEN, SPENCER R | Director | ストックオプション | 売却 | 12,500 | $0.00 |
| 2017-02-06 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 19 | $7.25 |
| 2017-02-06 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 19 | $46.50 |
| 2017-02-06 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 481 | $46.50 |
| 2017-02-06 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 481 | $0.00 |
| 2017-02-06 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 481 | $10.82 |
| 2017-02-06 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,000 | $46.00 |
| 2017-02-06 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 19 | $0.00 |
| 2017-02-03 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 937 | $0.00 |
| 2017-02-03 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 937 | $0.00 |
| 2017-01-17 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 256 | $46.29 |
| 2017-01-17 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 733 | $46.29 |
| 2017-01-17 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 623 | $46.29 |
| 2017-01-17 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 553 | $46.29 |
| 2017-01-17 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 733 | $46.29 |
| 2017-01-17 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 512 | $46.29 |
| 2017-01-17 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 623 | $46.29 |
| 2017-01-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 139 | $46.29 |
| 2017-01-17 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 512 | $46.29 |
| 2017-01-17 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 256 | $46.29 |
| 2017-01-17 | BOYCE, SARAH | Chief Business Officer | 普通株式 | 売却 | 855 | $46.29 |
| 2017-01-17 | BOYCE, SARAH | Chief Business Officer | 普通株式 | 売却 | 506 | $46.29 |
| 2017-01-17 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 122 | $46.29 |
| 2017-01-17 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 553 | $46.29 |
| 2017-01-17 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 733 | $46.29 |
| 2017-01-17 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 733 | $46.29 |
| 2017-01-17 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 539 | $46.29 |
| 2017-01-17 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 623 | $46.29 |
| 2017-01-17 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 546 | $46.29 |
| 2017-01-17 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 733 | $46.29 |
| 2017-01-17 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 539 | $46.29 |
| 2017-01-17 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 623 | $46.29 |
| 2017-01-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 3,008 | $46.29 |
| 2017-01-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 4,236 | $46.29 |
| 2017-01-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 4,410 | $46.29 |
| 2017-01-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 3,728 | $46.29 |
| 2017-01-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 163 | $46.29 |
| 2017-01-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 142 | $46.29 |
| 2017-01-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 131 | $46.29 |
| 2017-01-17 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 965 | $46.29 |
| 2017-01-17 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 1,509 | $46.29 |
| 2017-01-17 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 2,696 | $46.29 |
| 2017-01-17 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 2,076 | $46.29 |
| 2017-01-17 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 122 | $46.29 |
| 2017-01-17 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 623 | $46.29 |
| 2017-01-17 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 593 | $46.29 |
| 2017-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 1,518 | $0.00 |
| 2017-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,311 | $0.00 |
| 2017-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 購入 | 7,537 | $0.00 |
| 2017-01-15 | BOYCE, SARAH | Chief Business Officer | 普通株式 | 購入 | 2,188 | $0.00 |
| 2017-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 312 | $0.00 |
| 2017-01-15 | BOYCE, SARAH | Chief Business Officer | 普通株式 | 購入 | 1,295 | $0.00 |
| 2017-01-15 | BOYCE, SARAH | Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 7,537 | $0.00 |
| 2017-01-15 | BOYCE, SARAH | Chief Business Officer | 譲渡制限付株式ユニット | 売却 | 2,188 | $0.00 |
| 2017-01-15 | BOYCE, SARAH | Chief Business Officer | 譲渡制限付株式ユニット | 売却 | 1,295 | $0.00 |
| 2017-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 1,415 | $0.00 |
| 2017-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 1,875 | $0.00 |
| 2017-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 1,594 | $0.00 |
| 2017-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 購入 | 8,000 | $0.00 |
| 2017-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 1,415 | $0.00 |
| 2017-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2017-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 1,518 | $0.00 |
| 2017-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 1,594 | $0.00 |
| 2017-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 1,380 | $0.00 |
| 2017-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2017-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 1,397 | $0.00 |
| 2017-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 1,875 | $0.00 |
| 2017-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 312 | $0.00 |
| 2017-01-15 | PARSHALL, B LYNNE | Director, COO | 譲渡制限付株式ユニット | 売却 | 4,482 | $0.00 |
| 2017-01-15 | PARSHALL, B LYNNE | Director, COO | 譲渡制限付株式ユニット | 売却 | 5,519 | $0.00 |
| 2017-01-15 | PARSHALL, B LYNNE | Director, COO | 譲渡制限付株式ユニット | 売却 | 3,437 | $0.00 |
| 2017-01-15 | PARSHALL, B LYNNE | Director, COO | 譲渡制限付株式ユニット | 売却 | 2,595 | $0.00 |
| 2017-01-15 | PARSHALL, B LYNNE | Director, COO | 譲渡制限付株式ユニット | 購入 | 19,606 | $0.00 |
| 2017-01-15 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 4,482 | $0.00 |
| 2017-01-15 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 5,519 | $0.00 |
| 2017-01-15 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 3,437 | $0.00 |
| 2017-01-15 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 2,595 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 334 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 363 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 354 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 416 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 8,133 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 6,875 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 7,812 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 5,547 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 購入 | 2,692 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 購入 | 27,168 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 334 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 363 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 416 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 8,133 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 6,875 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 7,812 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,547 | $0.00 |
| 2017-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 1,594 | $0.00 |
| 2017-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 1,311 | $0.00 |
| 2017-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 購入 | 7,537 | $0.00 |
| 2017-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 1,594 | $0.00 |
| 2017-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 1,380 | $0.00 |
| 2017-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 1,875 | $0.00 |
| 2017-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 1,397 | $0.00 |
| 2017-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 1,594 | $0.00 |
| 2017-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 1,380 | $0.00 |
| 2017-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2017-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 653 | $0.00 |
| 2017-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 312 | $0.00 |
| 2017-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 7,537 | $0.00 |
| 2017-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 1,594 | $0.00 |
| 2017-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 1,380 | $0.00 |
| 2017-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 653 | $0.00 |
| 2017-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 354 | $0.00 |
| 2017-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 1,415 | $0.00 |
| 2017-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 1,594 | $0.00 |
| 2017-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2017-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 1,415 | $0.00 |
| 2017-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 購入 | 7,537 | $0.00 |
| 2017-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 1,594 | $0.00 |
| 2017-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 1,311 | $0.00 |
| 2017-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 1,875 | $0.00 |
| 2017-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 1,311 | $0.00 |
| 2017-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2017-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 653 | $0.00 |
| 2017-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 312 | $0.00 |
| 2017-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,594 | $0.00 |
| 2017-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,875 | $0.00 |
| 2017-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 653 | $0.00 |
| 2017-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 1,594 | $0.00 |
| 2017-01-10 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,200 | $49.25 |
| 2017-01-10 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,200 | $0.00 |
| 2017-01-10 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 12,000 | $0.00 |
| 2017-01-10 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 12,000 | $49.25 |
| 2017-01-10 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,200 | $10.29 |
| 2017-01-10 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 12,000 | $7.25 |
| 2017-01-04 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 7,000 | $50.10 |
| 2017-01-04 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 7,000 | $7.25 |
| 2017-01-04 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 700 | $0.00 |
| 2017-01-04 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 7,000 | $0.00 |
| 2017-01-04 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 700 | $50.10 |
| 2017-01-04 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 700 | $10.29 |
| 2017-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $47.30 |
| 2017-01-03 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 購入 | 117,638 | $0.00 |
| 2017-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,000 | $7.25 |
| 2017-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2017-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 500 | $10.29 |
| 2017-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2017-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 購入 | 163,013 | $0.00 |
| 2017-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 購入 | 16,157 | $0.00 |
| 2017-01-03 | BOYCE, SARAH | Chief Business Officer | ストックオプション | 購入 | 45,225 | $0.00 |
| 2017-01-03 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 309 | $48.60 |
| 2017-01-03 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 購入 | 48,000 | $0.00 |
| 2017-01-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 購入 | 45,225 | $0.00 |
| 2017-01-03 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 購入 | 45,225 | $0.00 |
| 2017-01-03 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 購入 | 45,225 | $0.00 |
| 2017-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $48.80 |
| 2017-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $47.30 |
| 2017-01-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $48.80 |
| 2017-01-03 | GEARY, RICHARD S | SVP, Development | ストックオプション | 購入 | 45,225 | $0.00 |
| 2017-01-01 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 171 | $20.76 |
| 2017-01-01 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 640 | $20.76 |
| 2017-01-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 211 | $20.76 |
| 2017-01-01 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 199 | $20.76 |
| 2017-01-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 424 | $20.76 |
| 2017-01-01 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 309 | $20.76 |
| 2017-01-01 | BOYCE, SARAH | Chief Business Officer | 普通株式 | 購入 | 992 | $20.76 |
| 2016-12-20 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 130 | $52.48 |
| 2016-12-15 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 1,000 | $7.25 |
| 2016-12-15 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 1,000 | $50.00 |
| 2016-12-15 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2016-12-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 350 | $45.00 |
| 2016-12-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 350 | $0.00 |
| 2016-12-05 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 2,500 | $46.05 |
| 2016-12-05 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 2,500 | $0.00 |
| 2016-12-05 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 2,500 | $11.27 |
| 2016-12-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 350 | $10.82 |
| 2016-12-01 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 7,000 | $14.69 |
| 2016-12-01 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 7,000 | $41.49 |
| 2016-12-01 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 5,500 | $14.69 |
| 2016-12-01 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 5,500 | $43.17 |
| 2016-12-01 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 12,500 | $0.00 |
| 2016-11-14 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 194 | $45.00 |
| 2016-11-14 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 806 | $0.00 |
| 2016-11-14 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 194 | $0.00 |
| 2016-11-14 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 806 | $45.00 |
| 2016-11-14 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 806 | $10.82 |
| 2016-11-14 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 194 | $10.82 |
| 2016-11-14 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 2,500 | $0.00 |
| 2016-11-14 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 2,500 | $47.50 |
| 2016-11-14 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 2,500 | $11.27 |
| 2016-11-11 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 2,500 | $41.00 |
| 2016-11-11 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 2,500 | $11.27 |
| 2016-11-11 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 2,500 | $0.00 |
| 2016-11-10 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2016-11-10 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2016-11-10 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,000 | $10.29 |
| 2016-11-10 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $7.25 |
| 2016-11-10 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $42.22 |
| 2016-11-10 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $40.23 |
| 2016-11-09 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 5,000 | $34.08 |
| 2016-11-09 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 2,500 | $38.49 |
| 2016-11-09 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 17,805 | $11.27 |
| 2016-11-09 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 17,805 | $38.54 |
| 2016-11-09 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 22,805 | $0.00 |
| 2016-11-09 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $35.55 |
| 2016-11-09 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 6,259 | $10.29 |
| 2016-11-09 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $37.25 |
| 2016-11-09 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 3,741 | $37.50 |
| 2016-11-09 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 6,259 | $37.10 |
| 2016-11-09 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,000 | $10.29 |
| 2016-11-09 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 16,259 | $0.00 |
| 2016-11-09 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 3,741 | $0.00 |
| 2016-11-09 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $35.10 |
| 2016-11-09 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 5,000 | $11.27 |
| 2016-11-09 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 2,000 | $0.00 |
| 2016-11-09 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 2,500 | $11.27 |
| 2016-11-09 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 3,741 | $7.25 |
| 2016-11-09 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $10.29 |
| 2016-11-09 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 2,500 | $0.00 |
| 2016-11-07 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 5,000 | $34.00 |
| 2016-11-07 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 5,000 | $11.27 |
| 2016-11-07 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 5,000 | $0.00 |
| 2016-10-05 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $10.29 |
| 2016-10-05 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2016-10-05 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2016-10-05 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $36.61 |
| 2016-10-05 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $36.61 |
| 2016-10-05 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,000 | $10.29 |
| 2016-09-27 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 20,000 | $36.02 |
| 2016-09-27 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 2,000 | $0.00 |
| 2016-09-27 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2016-09-27 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 2,000 | $36.05 |
| 2016-09-27 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 2,000 | $10.29 |
| 2016-09-27 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 20,000 | $10.29 |
| 2016-09-21 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 20,000 | $35.50 |
| 2016-09-21 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2016-09-21 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 2,000 | $0.00 |
| 2016-09-21 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 2,000 | $35.50 |
| 2016-09-21 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 2,000 | $10.29 |
| 2016-09-21 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 20,000 | $10.29 |
| 2016-09-01 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 3,635 | $0.00 |
| 2016-09-01 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 8,865 | $0.00 |
| 2016-09-01 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 3,635 | $30.05 |
| 2016-09-01 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 3,635 | $14.69 |
| 2016-09-01 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 8,865 | $29.82 |
| 2016-09-01 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 8,865 | $7.25 |
| 2016-07-02 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 312 | $0.00 |
| 2016-07-02 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 312 | $0.00 |
| 2016-07-02 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 312 | $0.00 |
| 2016-07-02 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 312 | $0.00 |
| 2016-07-02 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 312 | $0.00 |
| 2016-07-02 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 312 | $0.00 |
| 2016-07-02 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 312 | $0.00 |
| 2016-07-02 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 312 | $0.00 |
| 2016-07-01 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2016-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2016-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 1,803 | $0.00 |
| 2016-07-01 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 469 | $0.00 |
| 2016-07-01 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2016-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2016-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 1,803 | $0.00 |
| 2016-07-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 213 | $20.76 |
| 2016-07-01 | BOYCE, SARAH | Chief Business Officer | 普通株式 | 購入 | 403 | $20.76 |
| 2016-07-01 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 163 | $20.76 |
| 2016-07-01 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 217 | $20.76 |
| 2016-07-01 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 469 | $0.00 |
| 2016-07-01 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2016-07-01 | CASTLEMAN, BREAUX | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2016-07-01 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 309 | $20.76 |
| 2016-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2016-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 1,803 | $0.00 |
| 2016-07-01 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2016-07-01 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 469 | $0.00 |
| 2016-07-01 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2016-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2016-07-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 402 | $20.76 |
| 2016-07-01 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 403 | $20.76 |
| 2016-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 2,740 | $0.00 |
| 2016-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2016-07-01 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 937 | $0.00 |
| 2016-07-01 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 469 | $0.00 |
| 2016-07-01 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2016-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2016-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 1,803 | $0.00 |
| 2016-07-01 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 469 | $0.00 |
| 2016-07-01 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2016-07-01 | LOSCALZO, JOSEPH | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2016-07-01 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2016-07-01 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 1,334 | $0.00 |
| 2016-07-01 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2016-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2016-05-31 | MUTO, FREDERICK T | Director | ストックオプション | 売却 | 12,500 | $0.00 |
| 2016-05-31 | MUTO, FREDERICK T | Director | 普通株式 | 売却 | 12,500 | $22.31 |
| 2016-05-31 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 12,500 | $5.93 |
| 2016-04-06 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $45.95 |
| 2016-04-06 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2016-04-06 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,000 | $10.82 |
| 2016-04-06 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,000 | $45.00 |
| 2016-04-06 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,000 | $0.00 |
| 2016-04-06 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,000 | $10.29 |
| 2016-04-06 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $46.30 |
| 2016-04-06 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 500 | $10.29 |
| 2016-04-06 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $45.95 |
| 2016-04-06 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $46.30 |
| 2016-04-06 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2016-03-31 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $40.72 |
| 2016-03-31 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 500 | $0.00 |
| 2016-03-31 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2016-03-31 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $40.75 |
| 2016-03-31 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 500 | $10.29 |
| 2016-03-31 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $40.72 |
| 2016-03-31 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,000 | $10.29 |
| 2016-03-31 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 500 | $9.22 |
| 2016-03-31 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $40.75 |
| 2016-03-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,000 | $10.82 |
| 2016-03-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,000 | $0.00 |
| 2016-03-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,000 | $45.40 |
| 2016-02-19 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 12,500 | $5.93 |
| 2016-02-19 | BERTHELSEN, SPENCER R | Director | ストックオプション | 売却 | 12,500 | $0.00 |
| 2016-02-03 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 938 | $0.00 |
| 2016-02-03 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 938 | $0.00 |
| 2016-01-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 124 | $41.46 |
| 2016-01-19 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 550 | $41.47 |
| 2016-01-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 83 | $41.47 |
| 2016-01-19 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 747 | $41.47 |
| 2016-01-19 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 309 | $41.46 |
| 2016-01-19 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 261 | $41.46 |
| 2016-01-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 3,798 | $41.47 |
| 2016-01-19 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 125 | $41.46 |
| 2016-01-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 747 | $41.46 |
| 2016-01-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 522 | $41.46 |
| 2016-01-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 4,317 | $41.46 |
| 2016-01-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 125 | $41.46 |
| 2016-01-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 3,065 | $41.46 |
| 2016-01-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 210 | $41.46 |
| 2016-01-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,645 | $41.46 |
| 2016-01-19 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 1,219 | $41.46 |
| 2016-01-19 | BOYCE, SARAH | Chief Business Officer | 普通株式 | 売却 | 872 | $41.46 |
| 2016-01-19 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 277 | $41.46 |
| 2016-01-19 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 564 | $41.46 |
| 2016-01-19 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 747 | $41.46 |
| 2016-01-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 216 | $41.46 |
| 2016-01-19 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 550 | $41.46 |
| 2016-01-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 604 | $41.46 |
| 2016-01-19 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 747 | $41.46 |
| 2016-01-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 564 | $41.46 |
| 2016-01-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 145 | $41.46 |
| 2016-01-19 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 522 | $41.46 |
| 2016-01-19 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 2,303 | $41.46 |
| 2016-01-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 141 | $41.46 |
| 2016-01-19 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 1,003 | $41.47 |
| 2016-01-19 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 556 | $41.47 |
| 2016-01-19 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 667 | $41.46 |
| 2016-01-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 166 | $41.46 |
| 2016-01-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 747 | $41.47 |
| 2016-01-19 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 216 | $41.47 |
| 2016-01-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 261 | $41.46 |
| 2016-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 5,519 | $0.00 |
| 2016-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 2,595 | $0.00 |
| 2016-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,311 | $0.00 |
| 2016-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,875 | $0.00 |
| 2016-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 1,380 | $0.00 |
| 2016-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 1,380 | $0.00 |
| 2016-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 1,875 | $0.00 |
| 2016-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 購入 | 6,373 | $0.00 |
| 2016-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2016-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 購入 | 6,373 | $0.00 |
| 2016-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 541 | $0.00 |
| 2016-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 312 | $0.00 |
| 2016-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 654 | $0.00 |
| 2016-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2016-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 1,311 | $0.00 |
| 2016-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 1,715 | $0.00 |
| 2016-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 3,438 | $0.00 |
| 2016-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 208 | $0.00 |
| 2016-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 1,415 | $0.00 |
| 2016-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2016-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 1,518 | $0.00 |
| 2016-01-15 | BOYCE, SARAH | Chief Business Officer | 普通株式 | 購入 | 2,188 | $0.00 |
| 2016-01-15 | BOYCE, SARAH | Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 5,178 | $0.00 |
| 2016-01-15 | BOYCE, SARAH | Chief Business Officer | 譲渡制限付株式ユニット | 売却 | 2,188 | $0.00 |
| 2016-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 694 | $0.00 |
| 2016-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 1,415 | $0.00 |
| 2016-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 1,875 | $0.00 |
| 2016-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 1,311 | $0.00 |
| 2016-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 1,311 | $0.00 |
| 2016-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 654 | $0.00 |
| 2016-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 527 | $0.00 |
| 2016-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 購入 | 6,373 | $0.00 |
| 2016-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 694 | $0.00 |
| 2016-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 1,415 | $0.00 |
| 2016-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 1,518 | $0.00 |
| 2016-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 1,875 | $0.00 |
| 2016-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 1,415 | $0.00 |
| 2016-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 208 | $0.00 |
| 2016-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 527 | $0.00 |
| 2016-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 1,380 | $0.00 |
| 2016-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2016-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 1,397 | $0.00 |
| 2016-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 775 | $0.00 |
| 2016-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 購入 | 6,373 | $0.00 |
| 2016-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 1,380 | $0.00 |
| 2016-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 1,875 | $0.00 |
| 2016-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 541 | $0.00 |
| 2016-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 1,397 | $0.00 |
| 2016-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 654 | $0.00 |
| 2016-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 312 | $0.00 |
| 2016-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 541 | $0.00 |
| 2016-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2016-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 654 | $0.00 |
| 2016-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 312 | $0.00 |
| 2016-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 541 | $0.00 |
| 2016-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 6,373 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 363 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 354 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 416 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 316 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 6,875 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 7,813 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 5,547 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 2,977 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 購入 | 1,333 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 購入 | 32,530 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 363 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 354 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 416 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 316 | $0.00 |
| 2016-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 312 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 6,875 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 7,813 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,547 | $0.00 |
| 2016-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 2,977 | $0.00 |
| 2016-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 775 | $0.00 |
| 2016-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 譲渡制限付株式ユニット | 売却 | 5,519 | $0.00 |
| 2016-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 譲渡制限付株式ユニット | 売却 | 3,438 | $0.00 |
| 2016-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 譲渡制限付株式ユニット | 売却 | 2,595 | $0.00 |
| 2016-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 譲渡制限付株式ユニット | 売却 | 1,715 | $0.00 |
| 2016-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 譲渡制限付株式ユニット | 購入 | 17,925 | $0.00 |
| 2016-01-05 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,000 | $10.29 |
| 2016-01-05 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $62.10 |
| 2016-01-05 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 500 | $9.22 |
| 2016-01-05 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $62.10 |
| 2016-01-05 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 5,000 | $0.00 |
| 2016-01-05 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 500 | $0.00 |
| 2016-01-04 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,000 | $9.22 |
| 2016-01-04 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 購入 | 38,240 | $0.00 |
| 2016-01-04 | BOYCE, SARAH | Chief Business Officer | ストックオプション | 購入 | 31,070 | $0.00 |
| 2016-01-04 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2016-01-04 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2016-01-04 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 購入 | 8,000 | $0.00 |
| 2016-01-04 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 購入 | 195,182 | $0.00 |
| 2016-01-04 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $61.05 |
| 2016-01-04 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $61.05 |
| 2016-01-04 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $10.29 |
| 2016-01-04 | GEARY, RICHARD S | SVP, Development | ストックオプション | 購入 | 38,240 | $0.00 |
| 2016-01-04 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 127 | $61.00 |
| 2016-01-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 848 | $0.00 |
| 2016-01-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 152 | $0.00 |
| 2016-01-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 購入 | 38,240 | $0.00 |
| 2016-01-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 848 | $61.10 |
| 2016-01-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 848 | $7.25 |
| 2016-01-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 152 | $61.10 |
| 2016-01-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 152 | $10.82 |
| 2016-01-04 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 809 | $0.00 |
| 2016-01-04 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 購入 | 107,549 | $0.00 |
| 2016-01-04 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 809 | $61.05 |
| 2016-01-04 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 809 | $14.69 |
| 2016-01-04 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 購入 | 38,240 | $0.00 |
| 2016-01-04 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 購入 | 38,240 | $0.00 |
| 2016-01-01 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 41 | $47.71 |
| 2016-01-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 89 | $47.71 |
| 2016-01-01 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 130 | $47.71 |
| 2016-01-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 43 | $47.71 |
| 2016-01-01 | BOYCE, SARAH | Chief Business Officer | 普通株式 | 購入 | 419 | $47.71 |
| 2016-01-01 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 269 | $47.71 |
| 2016-01-01 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 72 | $47.71 |
| 2015-12-16 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 3,909 | $14.47 |
| 2015-12-16 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 3,909 | $58.85 |
| 2015-12-16 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 3,909 | $0.00 |
| 2015-12-15 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 4,000 | $0.00 |
| 2015-12-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 4,000 | $14.47 |
| 2015-12-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 4,000 | $56.00 |
| 2015-12-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,000 | $61.50 |
| 2015-12-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,000 | $7.25 |
| 2015-12-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,000 | $0.00 |
| 2015-11-11 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 3,125 | $12.94 |
| 2015-11-11 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 3,750 | $0.00 |
| 2015-11-11 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 3,125 | $0.00 |
| 2015-11-11 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 3,125 | $64.18 |
| 2015-11-11 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 3,750 | $9.30 |
| 2015-11-11 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 3,750 | $64.18 |
| 2015-11-10 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 5,000 | $14.47 |
| 2015-11-10 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 5,000 | $64.00 |
| 2015-11-10 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 5,000 | $0.00 |
| 2015-11-09 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 4,000 | $0.00 |
| 2015-11-09 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 購入 | 1,000 | $0.00 |
| 2015-11-06 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 5,000 | $0.00 |
| 2015-11-06 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 5,000 | $56.00 |
| 2015-11-06 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 5,000 | $14.47 |
| 2015-11-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,000 | $51.95 |
| 2015-11-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,000 | $7.25 |
| 2015-11-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,000 | $0.00 |
| 2015-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,000 | $10.29 |
| 2015-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 15,837 | $10.29 |
| 2015-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 15,837 | $44.18 |
| 2015-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 4,163 | $43.90 |
| 2015-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 4,163 | $11.27 |
| 2015-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 500 | $9.22 |
| 2015-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $45.30 |
| 2015-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 20,837 | $0.00 |
| 2015-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 2,500 | $0.00 |
| 2015-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 4,163 | $0.00 |
| 2015-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 2,000 | $44.18 |
| 2015-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 2,000 | $9.22 |
| 2015-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $45.30 |
| 2015-10-21 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 500 | $9.22 |
| 2015-10-21 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 15,000 | $11.27 |
| 2015-10-21 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 15,000 | $43.00 |
| 2015-10-21 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,000 | $11.27 |
| 2015-10-21 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $43.00 |
| 2015-10-21 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 500 | $43.00 |
| 2015-10-21 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 15,000 | $0.00 |
| 2015-10-21 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2015-10-21 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 500 | $0.00 |
| 2015-10-02 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 5,436 | $0.00 |
| 2015-10-02 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 2,000 | $14.69 |
| 2015-10-02 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 2,000 | $40.10 |
| 2015-10-02 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 3,436 | $14.69 |
| 2015-10-02 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 3,436 | $42.39 |
| 2015-10-01 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 2,838 | $0.00 |
| 2015-10-01 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 2,838 | $14.69 |
| 2015-10-01 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 4,162 | $40.13 |
| 2015-10-01 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 4,162 | $0.00 |
| 2015-10-01 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 2,838 | $40.13 |
| 2015-10-01 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 4,162 | $7.25 |
| 2015-07-17 | ISIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 売却 | 111,000 | $10.21 |
| 2015-07-16 | ISIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 売却 | 167,000 | $10.79 |
| 2015-07-15 | ISIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 売却 | 65,133 | $10.76 |
| 2015-07-06 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,175 | $0.00 |
| 2015-07-06 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,000 | $11.27 |
| 2015-07-06 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $57.01 |
| 2015-07-06 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,175 | $9.22 |
| 2015-07-06 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 1,375 | $10.29 |
| 2015-07-06 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 1,375 | $57.01 |
| 2015-07-06 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 4,843 | $7.25 |
| 2015-07-06 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 4,843 | $57.01 |
| 2015-07-06 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 1,375 | $0.00 |
| 2015-07-06 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 4,843 | $0.00 |
| 2015-07-06 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,175 | $57.01 |
| 2015-07-06 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 5,000 | $0.00 |
| 2015-07-02 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 312 | $0.00 |
| 2015-07-02 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 312 | $0.00 |
| 2015-07-02 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 198 | $56.30 |
| 2015-07-02 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 312 | $0.00 |
| 2015-07-02 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 312 | $0.00 |
| 2015-07-02 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 312 | $0.00 |
| 2015-07-02 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 312 | $0.00 |
| 2015-07-02 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 312 | $0.00 |
| 2015-07-02 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 312 | $0.00 |
| 2015-07-01 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 469 | $0.00 |
| 2015-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 5,000 | $0.00 |
| 2015-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,175 | $57.56 |
| 2015-07-01 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 71 | $48.59 |
| 2015-07-01 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 6,218 | $10.29 |
| 2015-07-01 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 6,218 | $57.56 |
| 2015-07-01 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 6,218 | $0.00 |
| 2015-07-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 85 | $48.59 |
| 2015-07-01 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 127 | $48.59 |
| 2015-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,175 | $0.00 |
| 2015-07-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 87 | $48.59 |
| 2015-07-01 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 469 | $0.00 |
| 2015-07-01 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 40 | $48.59 |
| 2015-07-01 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 265 | $48.59 |
| 2015-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,000 | $11.27 |
| 2015-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $57.56 |
| 2015-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,175 | $9.22 |
| 2015-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 469 | $0.00 |
| 2015-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2015-07-01 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2015-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2015-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 469 | $0.00 |
| 2015-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2015-07-01 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 938 | $0.00 |
| 2015-07-01 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 469 | $0.00 |
| 2015-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2015-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2015-07-01 | CASTLEMAN, BREAUX | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2015-07-01 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 469 | $0.00 |
| 2015-07-01 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2015-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2015-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 469 | $0.00 |
| 2015-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2015-07-01 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 469 | $0.00 |
| 2015-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2015-07-01 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2015-07-01 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2015-07-01 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2015-07-01 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2015-07-01 | LOSCALZO, JOSEPH | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2015-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2015-07-01 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2015-07-01 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2015-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 667 | $0.00 |
| 2015-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 469 | $0.00 |
| 2015-07-01 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2015-07-01 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 667 | $0.00 |
| 2015-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 938 | $0.00 |
| 2015-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 469 | $0.00 |
| 2015-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2015-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2015-06-30 | ISIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 売却 | 13,248 | $10.79 |
| 2015-06-23 | ISIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 購入 | 13,248 | $0.00 |
| 2015-06-08 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 7,600 | $10.29 |
| 2015-06-08 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 7,600 | $66.22 |
| 2015-06-08 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 売却 | 7,600 | $0.00 |
| 2015-06-01 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 10,000 | $3.95 |
| 2015-06-01 | MUTO, FREDERICK T | Director | 普通株式 | 売却 | 10,000 | $66.91 |
| 2015-06-01 | MUTO, FREDERICK T | Director | ストックオプション | 売却 | 10,000 | $0.00 |
| 2015-04-17 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 10,000 | $3.95 |
| 2015-04-17 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 10,000 | $0.00 |
| 2015-04-07 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 5,565 | $0.00 |
| 2015-04-07 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 5,565 | $14.69 |
| 2015-04-07 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 5,565 | $63.07 |
| 2015-04-07 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 20,343 | $11.27 |
| 2015-04-07 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 20,343 | $63.07 |
| 2015-04-07 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 2,034 | $9.22 |
| 2015-04-07 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 2,034 | $63.07 |
| 2015-04-07 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 20,343 | $0.00 |
| 2015-04-07 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 2,034 | $0.00 |
| 2015-04-01 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 5,377 | $0.00 |
| 2015-04-01 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 19,657 | $0.00 |
| 2015-04-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 19,657 | $61.93 |
| 2015-04-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 19,657 | $11.27 |
| 2015-04-01 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,966 | $0.00 |
| 2015-04-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,966 | $9.22 |
| 2015-04-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,966 | $61.93 |
| 2015-04-01 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 5,377 | $61.93 |
| 2015-04-01 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 5,377 | $14.69 |
| 2015-03-24 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 9,000 | $14.47 |
| 2015-03-24 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 9,000 | $71.01 |
| 2015-03-24 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 9,000 | $0.00 |
| 2015-03-23 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 1,000 | $14.47 |
| 2015-03-23 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 5,000 | $14.47 |
| 2015-03-23 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 6,000 | $0.00 |
| 2015-03-23 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 1,000 | $71.00 |
| 2015-03-23 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 5,000 | $69.80 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 10,525 | $75.00 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 5,683 | $0.00 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 6,100 | $0.00 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 4,000 | $0.00 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 13,125 | $0.00 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 4,000 | $74.77 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 4,000 | $10.82 |
| 2015-03-19 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 10,000 | $11.27 |
| 2015-03-19 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 10,000 | $73.33 |
| 2015-03-19 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2015-03-19 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 8,000 | $14.69 |
| 2015-03-19 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 8,000 | $75.00 |
| 2015-03-19 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 8,000 | $0.00 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,617 | $10.29 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,617 | $74.77 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 5,683 | $7.25 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 5,683 | $74.77 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 6,100 | $10.82 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 6,100 | $74.77 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 2,600 | $39.87 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 2,600 | $74.77 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 10,525 | $39.87 |
| 2015-03-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,617 | $0.00 |
| 2015-03-18 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 12,500 | $0.00 |
| 2015-03-18 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 6,100 | $5.93 |
| 2015-03-18 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 6,400 | $5.93 |
| 2015-03-18 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 6,100 | $70.95 |
| 2015-03-18 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 6,400 | $71.84 |
| 2015-03-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 4,133 | $0.00 |
| 2015-03-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,667 | $71.67 |
| 2015-03-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 4,133 | $10.29 |
| 2015-03-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 4,133 | $71.67 |
| 2015-03-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,667 | $0.00 |
| 2015-03-05 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 12,500 | $9.77 |
| 2015-03-05 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 12,500 | $71.61 |
| 2015-03-05 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 12,500 | $0.00 |
| 2015-03-05 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 3,750 | $9.22 |
| 2015-03-05 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 3,750 | $9.30 |
| 2015-03-05 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,500 | $12.94 |
| 2015-03-05 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 7,000 | $70.95 |
| 2015-03-05 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 3,750 | $0.00 |
| 2015-03-05 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 2,500 | $0.00 |
| 2015-03-05 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 3,015 | $71.67 |
| 2015-03-05 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 80 | $11.27 |
| 2015-03-05 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 80 | $71.67 |
| 2015-03-05 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 8,000 | $10.29 |
| 2015-03-05 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 8,000 | $71.67 |
| 2015-03-05 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 7,437 | $7.25 |
| 2015-03-05 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 7,437 | $71.32 |
| 2015-03-05 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 12,657 | $0.00 |
| 2015-03-05 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 8,000 | $71.67 |
| 2015-03-05 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 7,000 | $7.25 |
| 2015-03-05 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 7,000 | $70.32 |
| 2015-03-05 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 80 | $0.00 |
| 2015-03-05 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 8,000 | $0.00 |
| 2015-03-05 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 7,000 | $0.00 |
| 2015-03-05 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 12,657 | $14.47 |
| 2015-03-05 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 12,657 | $71.67 |
| 2015-03-05 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 8,000 | $7.25 |
| 2015-03-05 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 15,437 | $0.00 |
| 2015-03-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,667 | $8.00 |
| 2015-03-02 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 7,000 | $65.97 |
| 2015-02-12 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 10,000 | $0.00 |
| 2015-02-12 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 10,000 | $62.15 |
| 2015-02-12 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 10,000 | $3.95 |
| 2015-02-11 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 2,000 | $0.00 |
| 2015-02-03 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 売却 | 938 | $0.00 |
| 2015-02-03 | LOSCALZO, JOSEPH | Director | 普通株式 | 購入 | 938 | $0.00 |
| 2015-01-27 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $72.93 |
| 2015-01-27 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $11.27 |
| 2015-01-27 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $72.93 |
| 2015-01-27 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2015-01-27 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2015-01-27 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,000 | $9.22 |
| 2015-01-16 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 250 | $67.96 |
| 2015-01-16 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 1,372 | $67.96 |
| 2015-01-16 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 539 | $67.96 |
| 2015-01-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 121 | $67.96 |
| 2015-01-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 160 | $67.96 |
| 2015-01-16 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 207 | $67.96 |
| 2015-01-16 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 120 | $67.96 |
| 2015-01-16 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 250 | $67.96 |
| 2015-01-16 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 714 | $67.96 |
| 2015-01-16 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 296 | $67.96 |
| 2015-01-16 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 533 | $67.96 |
| 2015-01-16 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 714 | $67.96 |
| 2015-01-16 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 265 | $67.96 |
| 2015-01-16 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 714 | $67.96 |
| 2015-01-16 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 714 | $67.96 |
| 2015-01-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,574 | $67.96 |
| 2015-01-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 2,933 | $67.96 |
| 2015-01-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 4,130 | $67.96 |
| 2015-01-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 136 | $67.96 |
| 2015-01-16 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 80 | $67.96 |
| 2015-01-16 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 714 | $67.96 |
| 2015-01-16 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 539 | $67.96 |
| 2015-01-16 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 1,818 | $67.96 |
| 2015-01-16 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 207 | $67.96 |
| 2015-01-16 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 120 | $67.96 |
| 2015-01-16 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 201 | $67.96 |
| 2015-01-16 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 903 | $67.96 |
| 2015-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2015-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 1,415 | $0.00 |
| 2015-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 208 | $0.00 |
| 2015-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 527 | $0.00 |
| 2015-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 購入 | 6,070 | $0.00 |
| 2015-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 1,875 | $0.00 |
| 2015-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 1,415 | $0.00 |
| 2015-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2015-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 1,398 | $0.00 |
| 2015-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 776 | $0.00 |
| 2015-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 譲渡制限付株式ユニット | 売却 | 3,438 | $0.00 |
| 2015-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 527 | $0.00 |
| 2015-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 208 | $0.00 |
| 2015-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 694 | $0.00 |
| 2015-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2015-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 購入 | 5,518 | $0.00 |
| 2015-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 1,875 | $0.00 |
| 2015-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 1,398 | $0.00 |
| 2015-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 776 | $0.00 |
| 2015-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2015-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 1,415 | $0.00 |
| 2015-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 694 | $0.00 |
| 2015-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 購入 | 5,242 | $0.00 |
| 2015-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 1,875 | $0.00 |
| 2015-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,875 | $0.00 |
| 2015-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 313 | $0.00 |
| 2015-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 541 | $0.00 |
| 2015-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 1,875 | $0.00 |
| 2015-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 541 | $0.00 |
| 2015-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 5,518 | $0.00 |
| 2015-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 1,875 | $0.00 |
| 2015-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 譲渡制限付株式ユニット | 売却 | 2,595 | $0.00 |
| 2015-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 譲渡制限付株式ユニット | 売却 | 1,715 | $0.00 |
| 2015-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 譲渡制限付株式ユニット | 購入 | 22,076 | $0.00 |
| 2015-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 3,438 | $0.00 |
| 2015-01-15 | BOYCE, SARAH | Chief Business Officer | 譲渡制限付株式ユニット | 購入 | 8,750 | $0.00 |
| 2015-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 354 | $0.00 |
| 2015-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 417 | $0.00 |
| 2015-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 1,415 | $0.00 |
| 2015-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 2,595 | $0.00 |
| 2015-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 1,715 | $0.00 |
| 2015-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 417 | $0.00 |
| 2015-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 316 | $0.00 |
| 2015-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 7,813 | $0.00 |
| 2015-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 5,548 | $0.00 |
| 2015-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 2,977 | $0.00 |
| 2015-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 購入 | 1,450 | $0.00 |
| 2015-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 購入 | 27,500 | $0.00 |
| 2015-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 354 | $0.00 |
| 2015-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 316 | $0.00 |
| 2015-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 7,813 | $0.00 |
| 2015-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,548 | $0.00 |
| 2015-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 2,977 | $0.00 |
| 2015-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 654 | $0.00 |
| 2015-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 313 | $0.00 |
| 2015-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 541 | $0.00 |
| 2015-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 購入 | 5,242 | $0.00 |
| 2015-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 654 | $0.00 |
| 2015-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 654 | $0.00 |
| 2015-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 313 | $0.00 |
| 2015-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 654 | $0.00 |
| 2015-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 313 | $0.00 |
| 2015-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 541 | $0.00 |
| 2015-01-12 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 597 | $73.10 |
| 2015-01-09 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $73.57 |
| 2015-01-09 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2015-01-09 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2015-01-09 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $11.27 |
| 2015-01-09 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $73.57 |
| 2015-01-09 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,000 | $9.22 |
| 2015-01-07 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $68.05 |
| 2015-01-07 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $68.05 |
| 2015-01-07 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $11.27 |
| 2015-01-07 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2015-01-07 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2015-01-07 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,000 | $9.22 |
| 2015-01-06 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2015-01-06 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $66.04 |
| 2015-01-06 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2015-01-06 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $66.04 |
| 2015-01-06 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,000 | $9.22 |
| 2015-01-06 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $11.27 |
| 2015-01-02 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,217 | $10.82 |
| 2015-01-02 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 11,200 | $14.69 |
| 2015-01-02 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 11,200 | $62.12 |
| 2015-01-02 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 購入 | 132,458 | $0.00 |
| 2015-01-02 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 11,200 | $0.00 |
| 2015-01-02 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 購入 | 31,457 | $0.00 |
| 2015-01-02 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 購入 | 31,457 | $0.00 |
| 2015-01-02 | GEARY, RICHARD S | SVP, Development | ストックオプション | 購入 | 33,112 | $0.00 |
| 2015-01-02 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 76 | $62.75 |
| 2015-01-02 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 購入 | 36,423 | $0.00 |
| 2015-01-02 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 購入 | 33,112 | $0.00 |
| 2015-01-02 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 購入 | 8,700 | $0.00 |
| 2015-01-02 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 購入 | 165,000 | $0.00 |
| 2015-01-02 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 283 | $0.00 |
| 2015-01-02 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,217 | $0.00 |
| 2015-01-02 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 283 | $62.12 |
| 2015-01-02 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 283 | $7.25 |
| 2015-01-02 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,217 | $62.12 |
| 2015-01-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 136 | $30.05 |
| 2015-01-01 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 63 | $30.05 |
| 2015-01-01 | BOYCE, SARAH | Chief Business Officer | ストックオプション | 購入 | 52,500 | $0.00 |
| 2015-01-01 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 111 | $30.05 |
| 2015-01-01 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 198 | $30.05 |
| 2015-01-01 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 273 | $30.05 |
| 2015-01-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 329 | $30.05 |
| 2014-12-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 500 | $7.25 |
| 2014-12-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 500 | $52.21 |
| 2014-12-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,500 | $0.00 |
| 2014-12-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 500 | $50.37 |
| 2014-12-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 500 | $51.05 |
| 2014-11-03 | ISIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 売却 | 1,279,411 | $15.94 |
| 2014-11-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,500 | $0.00 |
| 2014-11-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,500 | $46.17 |
| 2014-11-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,500 | $7.25 |
| 2014-10-30 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 2,510 | $45.12 |
| 2014-10-30 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 2,510 | $0.00 |
| 2014-10-30 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 8,561 | $7.25 |
| 2014-10-30 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 8,561 | $45.12 |
| 2014-10-30 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 8,561 | $0.00 |
| 2014-10-30 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 2,510 | $14.69 |
| 2014-10-24 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,850 | $15.19 |
| 2014-10-24 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 350 | $15.50 |
| 2014-10-24 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 446 | $16.29 |
| 2014-10-24 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,054 | $14.63 |
| 2014-10-23 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,200 | $13.94 |
| 2014-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 3,000 | $14.47 |
| 2014-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $42.22 |
| 2014-10-23 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,700 | $14.24 |
| 2014-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 3,000 | $0.00 |
| 2014-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2014-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,600 | $9.22 |
| 2014-10-23 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 450 | $14.90 |
| 2014-10-23 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 50 | $15.45 |
| 2014-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,600 | $42.22 |
| 2014-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $11.27 |
| 2014-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 3,000 | $42.22 |
| 2014-10-23 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,600 | $0.00 |
| 2014-10-22 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 11,376 | $16.59 |
| 2014-10-22 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 15,156 | $14.67 |
| 2014-10-22 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 57,753 | $13.91 |
| 2014-10-22 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 9,283 | $12.18 |
| 2014-10-22 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 15,791 | $12.83 |
| 2014-10-22 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 109,534 | $14.00 |
| 2014-10-22 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 175 | $17.11 |
| 2014-10-17 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 3,000 | $6.79 |
| 2014-10-16 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 4,800 | $6.76 |
| 2014-10-15 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 4,300 | $6.67 |
| 2014-10-10 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 2,000 | $6.41 |
| 2014-10-09 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 4,750 | $6.58 |
| 2014-10-08 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 3,300 | $6.63 |
| 2014-10-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,000 | $9.22 |
| 2014-10-03 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 13,000 | $0.00 |
| 2014-10-03 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2014-10-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,000 | $39.49 |
| 2014-10-03 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 3,300 | $6.88 |
| 2014-10-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 13,000 | $14.47 |
| 2014-10-03 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 13,000 | $39.49 |
| 2014-10-02 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 3,750 | $6.64 |
| 2014-10-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 800 | $9.22 |
| 2014-10-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 20,000 | $14.47 |
| 2014-10-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 20,000 | $37.91 |
| 2014-10-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,200 | $11.27 |
| 2014-10-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 233 | $10.29 |
| 2014-10-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 467 | $7.25 |
| 2014-10-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 467 | $38.20 |
| 2014-10-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 800 | $7.25 |
| 2014-10-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 800 | $37.90 |
| 2014-10-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 233 | $0.00 |
| 2014-10-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,267 | $0.00 |
| 2014-10-01 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 3,250 | $6.71 |
| 2014-10-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,200 | $37.91 |
| 2014-10-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 800 | $37.91 |
| 2014-10-01 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2014-10-01 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,200 | $0.00 |
| 2014-10-01 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 800 | $0.00 |
| 2014-10-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 233 | $38.20 |
| 2014-09-26 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 2,500 | $7.04 |
| 2014-09-25 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 2,500 | $7.12 |
| 2014-09-24 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 3,750 | $7.19 |
| 2014-09-19 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 4,100 | $7.22 |
| 2014-09-18 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,500 | $7.40 |
| 2014-09-17 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 2,100 | $7.43 |
| 2014-09-12 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 3,500 | $7.96 |
| 2014-09-11 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 3,400 | $7.83 |
| 2014-09-10 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 2,000 | $7.70 |
| 2014-09-05 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 2,400 | $7.07 |
| 2014-09-04 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 6,000 | $7.11 |
| 2014-09-03 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,650 | $6.95 |
| 2014-09-02 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 売却 | 1,500 | $0.00 |
| 2014-09-02 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 10,628 | $10.29 |
| 2014-09-02 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 443 | $7.25 |
| 2014-09-02 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 10,628 | $40.24 |
| 2014-09-02 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 10,628 | $0.00 |
| 2014-09-02 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 443 | $0.00 |
| 2014-09-02 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 700 | $40.60 |
| 2014-09-02 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 700 | $10.29 |
| 2014-09-02 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 443 | $40.24 |
| 2014-09-02 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 800 | $10.29 |
| 2014-09-02 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 800 | $40.30 |
| 2014-08-29 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,500 | $6.84 |
| 2014-08-28 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 2,000 | $6.96 |
| 2014-08-27 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 2,000 | $40.55 |
| 2014-08-27 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 1,000 | $40.53 |
| 2014-08-27 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 1,000 | $15.38 |
| 2014-08-27 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 2,000 | $40.50 |
| 2014-08-27 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 2,000 | $15.38 |
| 2014-08-27 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,500 | $7.21 |
| 2014-08-27 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 5,000 | $0.00 |
| 2014-08-26 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 15,000 | $38.14 |
| 2014-08-26 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 2,344 | $11.27 |
| 2014-08-26 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 売却 | 10,000 | $0.00 |
| 2014-08-26 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 15,000 | $10.29 |
| 2014-08-26 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 売却 | 15,000 | $0.00 |
| 2014-08-26 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 売却 | 2,344 | $0.00 |
| 2014-08-26 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 2,344 | $38.14 |
| 2014-08-26 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 10,000 | $38.14 |
| 2014-08-26 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 10,000 | $7.25 |
| 2014-08-22 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 5,250 | $6.75 |
| 2014-08-21 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 2,500 | $6.89 |
| 2014-08-20 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 3,000 | $7.14 |
| 2014-08-15 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,450 | $6.98 |
| 2014-08-14 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,750 | $7.04 |
| 2014-08-13 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 購入 | 1,600 | $11.27 |
| 2014-08-13 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 2,250 | $7.02 |
| 2014-08-13 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 購入 | 15,500 | $14.47 |
| 2014-08-13 | CROOKE, STANLEY T | Director, Chairman, President and CEO | ストックオプション | 売却 | 1,600 | $0.00 |
| 2014-08-13 | CROOKE, STANLEY T | Director, Chairman, President and CEO | ストックオプション | 売却 | 15,500 | $0.00 |
| 2014-08-13 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 売却 | 1,600 | $35.45 |
| 2014-08-13 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 売却 | 15,500 | $35.45 |
| 2014-08-12 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 800 | $35.00 |
| 2014-08-12 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 売却 | 800 | $0.00 |
| 2014-08-12 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 800 | $10.29 |
| 2014-08-11 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 売却 | 700 | $0.00 |
| 2014-08-11 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 700 | $35.00 |
| 2014-08-11 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 700 | $10.29 |
| 2014-08-08 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,850 | $6.80 |
| 2014-08-07 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 2,600 | $6.66 |
| 2014-08-06 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 3,150 | $7.08 |
| 2014-08-01 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 2,600 | $6.21 |
| 2014-08-01 | CROOKE, STANLEY T | Director, Chairman, President and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2014-08-01 | CROOKE, STANLEY T | Director, Chairman, President and CEO | ストックオプション | 売却 | 15,000 | $0.00 |
| 2014-08-01 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 売却 | 1,000 | $30.53 |
| 2014-08-01 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 購入 | 1,000 | $11.27 |
| 2014-08-01 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 購入 | 15,000 | $14.47 |
| 2014-08-01 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 売却 | 15,000 | $30.53 |
| 2014-07-31 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 79 | $31.50 |
| 2014-07-31 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,750 | $6.42 |
| 2014-07-30 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,000 | $6.60 |
| 2014-07-25 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,700 | $6.55 |
| 2014-07-24 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,850 | $6.81 |
| 2014-07-23 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,700 | $6.88 |
| 2014-07-18 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 5,000 | $6.80 |
| 2014-07-17 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 5,000 | $6.58 |
| 2014-07-16 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 3,500 | $6.59 |
| 2014-07-11 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,750 | $6.48 |
| 2014-07-10 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 4,500 | $6.69 |
| 2014-07-09 | ISIS, PHARMACEUTICALS INC | Director, 10% Owner | 普通株式 | 売却 | 1,800 | $7.08 |
| 2014-07-03 | ISIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 売却 | 1,200 | $8.07 |
| 2014-07-02 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 313 | $0.00 |
| 2014-07-02 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 313 | $0.00 |
| 2014-07-02 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 164 | $35.95 |
| 2014-07-02 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 313 | $0.00 |
| 2014-07-02 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 313 | $0.00 |
| 2014-07-02 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 313 | $0.00 |
| 2014-07-02 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 313 | $0.00 |
| 2014-07-02 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 313 | $0.00 |
| 2014-07-02 | ISIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 売却 | 3,100 | $8.07 |
| 2014-07-02 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 313 | $0.00 |
| 2014-07-01 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 469 | $0.00 |
| 2014-07-01 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 597 | $30.20 |
| 2014-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,800 | $0.00 |
| 2014-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 200 | $0.00 |
| 2014-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 購入 | 15,500 | $0.00 |
| 2014-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,800 | $35.55 |
| 2014-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,800 | $11.27 |
| 2014-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 200 | $35.55 |
| 2014-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 200 | $14.47 |
| 2014-07-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,500 | $35.33 |
| 2014-07-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,500 | $0.00 |
| 2014-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 15,500 | $14.47 |
| 2014-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 15,500 | $35.58 |
| 2014-07-01 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 469 | $0.00 |
| 2014-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 469 | $0.00 |
| 2014-07-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 403 | $30.20 |
| 2014-07-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,500 | $10.29 |
| 2014-07-01 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 469 | $0.00 |
| 2014-07-01 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2014-07-01 | LOSCALZO, JOSEPH | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2014-07-01 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2014-07-01 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2014-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2014-07-01 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 469 | $0.00 |
| 2014-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2014-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2014-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 469 | $0.00 |
| 2014-07-01 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 469 | $0.00 |
| 2014-07-01 | CASTLEMAN, BREAUX | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2014-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2014-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 938 | $0.00 |
| 2014-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 売却 | 469 | $0.00 |
| 2014-07-01 | CASTLEMAN, BREAUX | Director | 普通株式 | 購入 | 938 | $0.00 |
| 2014-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 469 | $0.00 |
| 2014-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 469 | $0.00 |
| 2014-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2014-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 購入 | 2,667 | $0.00 |
| 2014-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 16,000 | $0.00 |
| 2014-07-01 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 284 | $30.20 |
| 2014-07-01 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 76 | $30.20 |
| 2014-07-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 291 | $30.20 |
| 2014-06-27 | ISIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 売却 | 3,150 | $7.91 |
| 2014-06-26 | ISIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 売却 | 1,700 | $7.89 |
| 2014-06-25 | ISIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 売却 | 2,750 | $7.84 |
| 2014-06-23 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 11,200 | $0.00 |
| 2014-06-23 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 5,000 | $36.54 |
| 2014-06-23 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 6,200 | $15.38 |
| 2014-06-23 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 6,200 | $36.97 |
| 2014-06-23 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 5,000 | $15.38 |
| 2014-06-19 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 200 | $10.29 |
| 2014-06-19 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 売却 | 11,000 | $35.10 |
| 2014-06-19 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 100 | $10.29 |
| 2014-06-19 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 売却 | 667 | $0.00 |
| 2014-06-19 | CROOKE, STANLEY T | Director, Chairman, President and CEO | ストックオプション | 売却 | 11,000 | $0.00 |
| 2014-06-19 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 100 | $35.28 |
| 2014-06-19 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 購入 | 11,000 | $14.47 |
| 2014-06-19 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 200 | $35.29 |
| 2014-06-19 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 300 | $35.45 |
| 2014-06-19 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 売却 | 33 | $0.00 |
| 2014-06-19 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 67 | $35.27 |
| 2014-06-19 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 67 | $10.29 |
| 2014-06-19 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 300 | $10.29 |
| 2014-06-19 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 33 | $35.27 |
| 2014-06-19 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 33 | $8.00 |
| 2014-06-16 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 200 | $35.25 |
| 2014-06-16 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 売却 | 800 | $0.00 |
| 2014-06-16 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 100 | $35.25 |
| 2014-06-16 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 200 | $8.00 |
| 2014-06-16 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 400 | $35.02 |
| 2014-06-16 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 100 | $35.27 |
| 2014-06-16 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 100 | $8.00 |
| 2014-06-16 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 400 | $8.00 |
| 2014-06-10 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 売却 | 10,000 | $33.46 |
| 2014-06-10 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 購入 | 1,000 | $14.47 |
| 2014-06-10 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 購入 | 10,000 | $14.47 |
| 2014-06-10 | CROOKE, STANLEY T | Director, Chairman, President and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2014-06-10 | CROOKE, STANLEY T | Director, Chairman, President and CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2014-06-10 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 売却 | 1,000 | $33.46 |
| 2014-06-02 | MUTO, FREDERICK T | Director | ストックオプション | 売却 | 10,000 | $0.00 |
| 2014-06-02 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 10,000 | $5.72 |
| 2014-06-02 | MUTO, FREDERICK T | Director | 普通株式 | 売却 | 10,000 | $28.59 |
| 2014-04-17 | BERTHELSEN, SPENCER R | Director | ストックオプション | 売却 | 10,000 | $0.00 |
| 2014-04-17 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 10,000 | $5.72 |
| 2014-04-02 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 購入 | 1,800 | $14.47 |
| 2014-04-02 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 売却 | 7,000 | $43.65 |
| 2014-04-02 | CROOKE, STANLEY T | Director, Chairman, President and CEO | ストックオプション | 売却 | 7,000 | $0.00 |
| 2014-04-02 | CROOKE, STANLEY T | Director, Chairman, President and CEO | ストックオプション | 売却 | 1,800 | $0.00 |
| 2014-04-02 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 売却 | 1,800 | $43.65 |
| 2014-04-02 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 購入 | 7,000 | $14.47 |
| 2014-04-01 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 500 | $44.88 |
| 2014-04-01 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 売却 | 1,500 | $0.00 |
| 2014-04-01 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 500 | $8.00 |
| 2014-04-01 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 500 | $44.02 |
| 2014-04-01 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 500 | $44.30 |
| 2014-03-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 800 | $10.82 |
| 2014-03-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 370 | $49.20 |
| 2014-03-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 330 | $10.82 |
| 2014-03-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,130 | $0.00 |
| 2014-03-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 330 | $49.20 |
| 2014-03-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 370 | $0.00 |
| 2014-03-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 800 | $50.70 |
| 2014-03-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 370 | $11.27 |
| 2014-02-06 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 5,300 | $0.00 |
| 2014-02-06 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 5,300 | $5.72 |
| 2014-02-03 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 4,700 | $48.78 |
| 2014-02-03 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 4,700 | $0.00 |
| 2014-02-03 | LOSCALZO, JOSEPH | Director | ストックオプション | 購入 | 22,500 | $0.00 |
| 2014-02-03 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 4,700 | $5.72 |
| 2014-02-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,500 | $0.00 |
| 2014-02-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,500 | $50.45 |
| 2014-02-03 | LOSCALZO, JOSEPH | Director | 譲渡制限付株式ユニット | 購入 | 3,750 | $0.00 |
| 2014-02-03 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,500 | $11.27 |
| 2014-01-30 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 23,635 | $10.29 |
| 2014-01-30 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 23,635 | $50.36 |
| 2014-01-30 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 15,875 | $50.36 |
| 2014-01-30 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 15,875 | $0.00 |
| 2014-01-30 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 23,635 | $0.00 |
| 2014-01-30 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 15,875 | $7.25 |
| 2014-01-29 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 3,972 | $48.81 |
| 2014-01-29 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 31,028 | $10.29 |
| 2014-01-29 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 3,972 | $0.00 |
| 2014-01-29 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 5,000 | $0.00 |
| 2014-01-29 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 31,028 | $0.00 |
| 2014-01-29 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 5,000 | $48.81 |
| 2014-01-29 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 5,000 | $7.25 |
| 2014-01-29 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 31,028 | $48.81 |
| 2014-01-29 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 3,972 | $11.27 |
| 2014-01-24 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 7,500 | $48.68 |
| 2014-01-24 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 2,813 | $48.61 |
| 2014-01-24 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,813 | $12.94 |
| 2014-01-24 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 7,500 | $0.00 |
| 2014-01-24 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 2,813 | $0.00 |
| 2014-01-24 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 7,500 | $16.32 |
| 2014-01-22 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 13,900 | $0.00 |
| 2014-01-22 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 13,900 | $50.05 |
| 2014-01-22 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 13,900 | $7.25 |
| 2014-01-22 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 8,300 | $14.69 |
| 2014-01-22 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 10,000 | $50.98 |
| 2014-01-22 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 8,300 | $0.00 |
| 2014-01-22 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 購入 | 5,000 | $0.00 |
| 2014-01-22 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 8,300 | $50.05 |
| 2014-01-22 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 5,000 | $0.00 |
| 2014-01-16 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 202 | $47.08 |
| 2014-01-16 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 533 | $47.08 |
| 2014-01-16 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 250 | $47.08 |
| 2014-01-16 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 120 | $47.08 |
| 2014-01-16 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 250 | $47.08 |
| 2014-01-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 121 | $47.08 |
| 2014-01-16 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 207 | $47.08 |
| 2014-01-16 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 120 | $47.08 |
| 2014-01-16 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 539 | $47.08 |
| 2014-01-16 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 80 | $47.08 |
| 2014-01-16 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 653 | $47.08 |
| 2014-01-16 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 539 | $47.08 |
| 2014-01-16 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 265 | $47.08 |
| 2014-01-16 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 296 | $47.08 |
| 2014-01-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 160 | $47.08 |
| 2014-01-16 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 207 | $47.08 |
| 2014-01-16 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 988 | $47.08 |
| 2014-01-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 2,112 | $47.08 |
| 2014-01-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,134 | $47.08 |
| 2014-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 654 | $0.00 |
| 2014-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 2,978 | $0.00 |
| 2014-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 7,500 | $0.00 |
| 2014-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 417 | $0.00 |
| 2014-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 317 | $0.00 |
| 2014-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 2,978 | $0.00 |
| 2014-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 417 | $0.00 |
| 2014-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 1,715 | $0.00 |
| 2014-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 購入 | 7,500 | $0.00 |
| 2014-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 1,415 | $0.00 |
| 2014-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 1,415 | $0.00 |
| 2014-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 208 | $0.00 |
| 2014-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 695 | $0.00 |
| 2014-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 313 | $0.00 |
| 2014-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 購入 | 7,500 | $0.00 |
| 2014-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 1,415 | $0.00 |
| 2014-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 695 | $0.00 |
| 2014-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 776 | $0.00 |
| 2014-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 528 | $0.00 |
| 2014-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 1,398 | $0.00 |
| 2014-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 1,398 | $0.00 |
| 2014-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 313 | $0.00 |
| 2014-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 208 | $0.00 |
| 2014-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 1,415 | $0.00 |
| 2014-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 2,595 | $0.00 |
| 2014-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 313 | $0.00 |
| 2014-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 譲渡制限付株式ユニット | 購入 | 13,750 | $0.00 |
| 2014-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 譲渡制限付株式ユニット | 売却 | 1,715 | $0.00 |
| 2014-01-15 | PARSHALL, B LYNNE | Director, COO & Secretary | 譲渡制限付株式ユニット | 売却 | 2,595 | $0.00 |
| 2014-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,548 | $0.00 |
| 2014-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 528 | $0.00 |
| 2014-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 542 | $0.00 |
| 2014-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 654 | $0.00 |
| 2014-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 購入 | 31,250 | $0.00 |
| 2014-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 購入 | 1,416 | $0.00 |
| 2014-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 5,548 | $0.00 |
| 2014-01-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 譲渡制限付株式ユニット | 売却 | 317 | $0.00 |
| 2014-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 654 | $0.00 |
| 2014-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 542 | $0.00 |
| 2014-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 313 | $0.00 |
| 2014-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 購入 | 7,500 | $0.00 |
| 2014-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 654 | $0.00 |
| 2014-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 542 | $0.00 |
| 2014-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 776 | $0.00 |
| 2014-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 購入 | 7,500 | $0.00 |
| 2014-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 542 | $0.00 |
| 2014-01-08 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 7,600 | $10.29 |
| 2014-01-08 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 購入 | 11,000 | $14.47 |
| 2014-01-08 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 売却 | 11,000 | $40.05 |
| 2014-01-08 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 購入 | 1,500 | $14.47 |
| 2014-01-08 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 売却 | 1,500 | $40.05 |
| 2014-01-08 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 7,600 | $0.00 |
| 2014-01-08 | CROOKE, STANLEY T | Director, Chairman, President and CEO | ストックオプション | 売却 | 11,000 | $0.00 |
| 2014-01-08 | CROOKE, STANLEY T | Director, Chairman, President and CEO | ストックオプション | 売却 | 1,500 | $0.00 |
| 2014-01-08 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 7,600 | $42.02 |
| 2014-01-06 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 7,400 | $0.00 |
| 2014-01-06 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 7,400 | $38.83 |
| 2014-01-06 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 7,400 | $11.27 |
| 2014-01-02 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 売却 | 25,000 | $39.25 |
| 2014-01-02 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 購入 | 4,000 | $14.47 |
| 2014-01-02 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 売却 | 4,000 | $40.00 |
| 2014-01-02 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 購入 | 2,500 | $14.47 |
| 2014-01-02 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 362 | $39.25 |
| 2014-01-02 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 購入 | 82,500 | $0.00 |
| 2014-01-02 | CROOKE, STANLEY T | Director, Chairman, President and CEO | ストックオプション | 購入 | 187,500 | $0.00 |
| 2014-01-02 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 売却 | 2,500 | $39.25 |
| 2014-01-02 | CROOKE, STANLEY T | Director, Chairman, President and CEO | ストックオプション | 購入 | 8,500 | $0.00 |
| 2014-01-02 | GEARY, RICHARD S | SVP, Development | ストックオプション | 購入 | 45,000 | $0.00 |
| 2014-01-02 | HOUGEN, ELIZABETH L | SVP, Finance and CFO | ストックオプション | 購入 | 45,000 | $0.00 |
| 2014-01-02 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 購入 | 45,000 | $0.00 |
| 2014-01-02 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 購入 | 45,000 | $0.00 |
| 2014-01-02 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 購入 | 45,000 | $0.00 |
| 2014-01-02 | CROOKE, STANLEY T | Director, Chairman, President and CEO | 普通株式 | 購入 | 25,000 | $14.47 |
| 2014-01-01 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2014-01-01 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 79 | $24.20 |
| 2014-01-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 164 | $24.20 |
| 2014-01-01 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 164 | $24.20 |
| 2014-01-01 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 395 | $24.20 |
| 2014-01-01 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 397 | $24.20 |
| 2014-01-01 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 購入 | 5,000 | $0.00 |
| 2013-12-26 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 37,811 | $40.91 |
| 2013-12-26 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 37,811 | $11.27 |
| 2013-12-26 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 37,811 | $0.00 |
| 2013-12-24 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 20,000 | $0.00 |
| 2013-12-24 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 20,000 | $11.27 |
| 2013-12-24 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 20,000 | $41.00 |
| 2013-12-23 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 48,229 | $0.00 |
| 2013-12-23 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 48,229 | $14.47 |
| 2013-12-23 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 48,229 | $41.68 |
| 2013-12-23 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 1,771 | $11.27 |
| 2013-12-23 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 1,771 | $0.00 |
| 2013-12-23 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 1,771 | $41.68 |
| 2013-12-20 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 10,000 | $40.01 |
| 2013-12-19 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 15,000 | $0.00 |
| 2013-12-19 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 15,000 | $16.32 |
| 2013-12-19 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 9,731 | $39.13 |
| 2013-12-05 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 1,810 | $15.38 |
| 2013-12-05 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 3,640 | $39.94 |
| 2013-12-05 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 4,550 | $15.38 |
| 2013-12-05 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 4,550 | $39.90 |
| 2013-12-05 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 3,640 | $15.38 |
| 2013-12-05 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 1,810 | $39.92 |
| 2013-12-05 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 10,000 | $0.00 |
| 2013-11-26 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 10,000 | $36.63 |
| 2013-11-25 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 6,000 | $36.86 |
| 2013-09-20 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 売却 | 18,281 | $0.00 |
| 2013-09-20 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 18,281 | $35.89 |
| 2013-09-20 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 18,281 | $11.27 |
| 2013-09-20 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 10,000 | $0.00 |
| 2013-09-20 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 30,000 | $0.00 |
| 2013-09-20 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 10,000 | $35.90 |
| 2013-09-20 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 10,000 | $15.38 |
| 2013-09-20 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 30,000 | $35.90 |
| 2013-09-20 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 30,000 | $14.47 |
| 2013-09-20 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 8,740 | $0.00 |
| 2013-09-20 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 8,740 | $35.90 |
| 2013-09-20 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 8,740 | $11.12 |
| 2013-09-19 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 50,000 | $0.00 |
| 2013-09-19 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 20,000 | $35.12 |
| 2013-09-19 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 売却 | 30,000 | $35.02 |
| 2013-09-19 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 30,000 | $16.45 |
| 2013-09-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 売却 | 5,000 | $0.00 |
| 2013-09-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 1,875 | $11.27 |
| 2013-09-19 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 30,000 | $0.00 |
| 2013-09-19 | PARSHALL, B LYNNE | Director, COO & Secretary | ストックオプション | 売却 | 20,000 | $0.00 |
| 2013-09-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 1,875 | $33.35 |
| 2013-09-19 | PARSHALL, B LYNNE | Director, COO & Secretary | 普通株式 | 購入 | 20,000 | $15.38 |
| 2013-09-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 30,000 | $11.12 |
| 2013-09-19 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 10,000 | $0.00 |
| 2013-09-19 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 10,000 | $35.02 |
| 2013-09-19 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 10,000 | $15.38 |
| 2013-09-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 20,000 | $11.12 |
| 2013-09-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 30,000 | $35.02 |
| 2013-09-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 20,000 | $35.12 |
| 2013-09-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 売却 | 1,875 | $0.00 |
| 2013-09-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 売却 | 22,500 | $0.00 |
| 2013-09-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 売却 | 625 | $0.00 |
| 2013-09-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 売却 | 20,000 | $0.00 |
| 2013-09-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 22,500 | $33.35 |
| 2013-09-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 22,500 | $14.47 |
| 2013-09-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 5,000 | $33.35 |
| 2013-09-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 5,000 | $14.65 |
| 2013-09-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 625 | $33.35 |
| 2013-09-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 625 | $15.75 |
| 2013-09-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 20,000 | $33.96 |
| 2013-09-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 20,000 | $15.38 |
| 2013-09-11 | CROOKE, STANLEY T | Director, COO, President | 普通株式 | 売却 | 20,000 | $31.18 |
| 2013-09-11 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 1,520 | $15.38 |
| 2013-09-11 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 1,985 | $31.18 |
| 2013-09-11 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 1,520 | $31.18 |
| 2013-09-11 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 1,520 | $0.00 |
| 2013-09-10 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 30,000 | $0.00 |
| 2013-09-10 | CROOKE, STANLEY T | Director, COO, President | 普通株式 | 売却 | 30,000 | $31.65 |
| 2013-09-10 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 30,000 | $31.65 |
| 2013-09-10 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 30,000 | $15.38 |
| 2013-09-09 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 10,000 | $30.23 |
| 2013-09-09 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 10,000 | $0.00 |
| 2013-09-09 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 10,000 | $15.38 |
| 2013-09-09 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 30,000 | $15.38 |
| 2013-09-09 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 30,000 | $30.42 |
| 2013-09-09 | CROOKE, STANLEY T | Director, COO, President | 普通株式 | 購入 | 26,615 | $11.12 |
| 2013-09-09 | CROOKE, STANLEY T | Director, COO, President | ストックオプション | 売却 | 26,615 | $0.00 |
| 2013-09-09 | CROOKE, STANLEY T | Director, COO, President | 普通株式 | 売却 | 26,615 | $30.42 |
| 2013-09-09 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 30,000 | $0.00 |
| 2013-09-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 10 | $0.00 |
| 2013-09-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 10 | $26.85 |
| 2013-09-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 637 | $26.85 |
| 2013-09-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,317 | $27.25 |
| 2013-09-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 10 | $14.47 |
| 2013-09-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 637 | $11.27 |
| 2013-09-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 526 | $27.00 |
| 2013-09-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 2,480 | $0.00 |
| 2013-09-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 526 | $11.27 |
| 2013-09-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 10 | $0.00 |
| 2013-09-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,317 | $11.27 |
| 2013-09-04 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 10 | $14.18 |
| 2013-08-26 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 2,909 | $25.58 |
| 2013-08-09 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 3,647 | $13.88 |
| 2013-08-09 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 7,500 | $0.00 |
| 2013-08-09 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 7,500 | $9.22 |
| 2013-08-09 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 3,750 | $0.00 |
| 2013-08-09 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 3,647 | $28.22 |
| 2013-08-09 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 7,500 | $9.30 |
| 2013-08-09 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 7,500 | $28.22 |
| 2013-08-09 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 103 | $28.23 |
| 2013-08-09 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 103 | $13.88 |
| 2013-07-23 | CROOKE, STANLEY T | Director, COO, President | 普通株式 | 購入 | 11,500 | $11.12 |
| 2013-07-23 | CROOKE, STANLEY T | Director, COO, President | 普通株式 | 売却 | 11,500 | $30.00 |
| 2013-07-23 | CROOKE, STANLEY T | Director, COO, President | ストックオプション | 売却 | 11,500 | $0.00 |
| 2013-07-22 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $30.53 |
| 2013-07-22 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 18,115 | $0.00 |
| 2013-07-22 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 8,115 | $31.02 |
| 2013-07-22 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $15.38 |
| 2013-07-22 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 1,885 | $31.02 |
| 2013-07-22 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 1,885 | $11.12 |
| 2013-07-22 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 8,115 | $15.38 |
| 2013-07-22 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 1,885 | $0.00 |
| 2013-07-19 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 22,200 | $0.00 |
| 2013-07-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $30.19 |
| 2013-07-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 2,200 | $15.38 |
| 2013-07-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 2,200 | $31.40 |
| 2013-07-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $15.38 |
| 2013-07-19 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $30.87 |
| 2013-07-18 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $11.12 |
| 2013-07-18 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $30.02 |
| 2013-07-18 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $30.20 |
| 2013-07-18 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2013-07-17 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 8,300 | $0.00 |
| 2013-07-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,000 | $9.92 |
| 2013-07-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 8,256 | $15.38 |
| 2013-07-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 44 | $15.38 |
| 2013-07-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,000 | $31.96 |
| 2013-07-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 44 | $31.96 |
| 2013-07-17 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 8,256 | $31.22 |
| 2013-07-17 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 5,000 | $0.00 |
| 2013-07-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 6,000 | $11.12 |
| 2013-07-16 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 6,000 | $33.31 |
| 2013-07-16 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 6,000 | $0.00 |
| 2013-07-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $33.57 |
| 2013-07-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $34.05 |
| 2013-07-15 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 30,000 | $0.00 |
| 2013-07-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $11.12 |
| 2013-07-15 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $33.81 |
| 2013-07-12 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 6,000 | $0.00 |
| 2013-07-12 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 12,000 | $33.50 |
| 2013-07-12 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 12,000 | $33.08 |
| 2013-07-12 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 12,000 | $11.12 |
| 2013-07-12 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 6,000 | $32.83 |
| 2013-07-12 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 6,000 | $15.38 |
| 2013-07-12 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 24,000 | $0.00 |
| 2013-07-11 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 9,000 | $0.00 |
| 2013-07-11 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 30,000 | $32.00 |
| 2013-07-11 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 9,000 | $11.12 |
| 2013-07-11 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 30,000 | $0.00 |
| 2013-07-11 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 9,000 | $31.90 |
| 2013-07-11 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 30,000 | $15.38 |
| 2013-07-10 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 30,000 | $30.05 |
| 2013-07-10 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 30,000 | $15.38 |
| 2013-07-10 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 30,000 | $0.00 |
| 2013-07-09 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 30,000 | $30.04 |
| 2013-07-09 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 30,000 | $15.38 |
| 2013-07-09 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 10,358 | $0.00 |
| 2013-07-09 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 10,358 | $30.04 |
| 2013-07-09 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 10,358 | $10.29 |
| 2013-07-09 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 30,000 | $0.00 |
| 2013-07-08 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 5,007 | $11.27 |
| 2013-07-08 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 5,007 | $30.03 |
| 2013-07-08 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 17,933 | $11.27 |
| 2013-07-08 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 22,940 | $0.00 |
| 2013-07-08 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 7,060 | $0.00 |
| 2013-07-08 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 17,933 | $30.09 |
| 2013-07-08 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 7,060 | $10.29 |
| 2013-07-08 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,008 | $15.38 |
| 2013-07-08 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,008 | $30.03 |
| 2013-07-08 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 24,992 | $15.38 |
| 2013-07-08 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 30,000 | $0.00 |
| 2013-07-08 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 24,992 | $30.09 |
| 2013-07-08 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 7,060 | $30.09 |
| 2013-07-05 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 16,960 | $14.47 |
| 2013-07-05 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 16,960 | $30.02 |
| 2013-07-05 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 2,220 | $11.27 |
| 2013-07-05 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 1,625 | $29.25 |
| 2013-07-05 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 2,220 | $30.02 |
| 2013-07-05 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 5,000 | $19.08 |
| 2013-07-05 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 5,000 | $30.02 |
| 2013-07-05 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 16,960 | $0.00 |
| 2013-07-05 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 2,220 | $0.00 |
| 2013-07-05 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 5,000 | $0.00 |
| 2013-07-05 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 24,180 | $15.38 |
| 2013-07-05 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 24,180 | $30.02 |
| 2013-07-05 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 277 | $29.25 |
| 2013-07-05 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 24,180 | $0.00 |
| 2013-07-03 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 5,000 | $0.00 |
| 2013-07-03 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 5,000 | $19.08 |
| 2013-07-03 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 5,000 | $29.02 |
| 2013-07-02 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 313 | $0.00 |
| 2013-07-02 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 売却 | 313 | $0.00 |
| 2013-07-02 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 313 | $0.00 |
| 2013-07-02 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 売却 | 313 | $0.00 |
| 2013-07-02 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 313 | $0.00 |
| 2013-07-02 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 売却 | 313 | $0.00 |
| 2013-07-02 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 215 | $28.69 |
| 2013-07-02 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 313 | $0.00 |
| 2013-07-02 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 売却 | 313 | $0.00 |
| 2013-07-01 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 購入 | 1,875 | $0.00 |
| 2013-07-01 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $28.17 |
| 2013-07-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 756 | $9.20 |
| 2013-07-01 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 11,250 | $0.00 |
| 2013-07-01 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 購入 | 1,875 | $0.00 |
| 2013-07-01 | CASTLEMAN, BREAUX | Director | ストックオプション | 購入 | 11,250 | $0.00 |
| 2013-07-01 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 購入 | 1,875 | $0.00 |
| 2013-07-01 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 11,250 | $0.00 |
| 2013-07-01 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 購入 | 1,875 | $0.00 |
| 2013-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 11,250 | $0.00 |
| 2013-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 11,250 | $0.00 |
| 2013-07-01 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 購入 | 1,875 | $0.00 |
| 2013-07-01 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 817 | $9.20 |
| 2013-07-01 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 362 | $9.20 |
| 2013-07-01 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 976 | $9.20 |
| 2013-06-28 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 5,958 | $27.31 |
| 2013-06-28 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 5,958 | $11.12 |
| 2013-06-28 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 5,958 | $0.00 |
| 2013-06-28 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $6.81 |
| 2013-06-28 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $27.07 |
| 2013-06-28 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 4,725 | $6.81 |
| 2013-06-28 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 4,725 | $27.31 |
| 2013-06-28 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 4,725 | $0.00 |
| 2013-06-28 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2013-06-27 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $27.40 |
| 2013-06-27 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $28.30 |
| 2013-06-27 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,000 | $6.81 |
| 2013-06-27 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2013-06-26 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 20,000 | $27.10 |
| 2013-06-26 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,000 | $26.70 |
| 2013-06-26 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2013-06-26 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 20,000 | $6.81 |
| 2013-06-25 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 4,000 | $15.38 |
| 2013-06-25 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 4,000 | $28.32 |
| 2013-06-25 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 1,565 | $14.47 |
| 2013-06-25 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 1,565 | $28.32 |
| 2013-06-25 | CROOKE, STANLEY T | Director, Chairman and CEO | ストックオプション | 売却 | 30,000 | $0.00 |
| 2013-06-25 | CASTLEMAN, BREAUX | Director | 譲渡制限付株式ユニット | 購入 | 3,750 | $0.00 |
| 2013-06-25 | CASTLEMAN, BREAUX | Director | ストックオプション | 購入 | 22,500 | $0.00 |
| 2013-06-25 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 10,435 | $14.47 |
| 2013-06-25 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 10,435 | $6.81 |
| 2013-06-25 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 10,435 | $27.87 |
| 2013-06-25 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 1,049 | $6.81 |
| 2013-06-25 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 1,049 | $27.56 |
| 2013-06-25 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 1,049 | $0.00 |
| 2013-06-25 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 4,000 | $0.00 |
| 2013-06-25 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 12,000 | $0.00 |
| 2013-06-25 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 19,565 | $27.87 |
| 2013-06-25 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 購入 | 19,565 | $6.81 |
| 2013-06-25 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 10,435 | $28.32 |
| 2013-06-24 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 10,000 | $15.75 |
| 2013-06-24 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 10,000 | $25.16 |
| 2013-06-24 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 20,000 | $0.00 |
| 2013-06-24 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 10,000 | $0.00 |
| 2013-06-24 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 16,270 | $25.16 |
| 2013-06-24 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 6,270 | $15.38 |
| 2013-06-24 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 13,730 | $25.22 |
| 2013-06-24 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 13,730 | $15.38 |
| 2013-06-24 | CROOKE, STANLEY T | Director, Chairman and CEO | 普通株式 | 売却 | 13,730 | $25.22 |
| 2013-06-24 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 6,270 | $25.16 |
| 2013-06-20 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 5,447 | $20.93 |
| 2013-06-20 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 10,000 | $5.17 |
| 2013-06-20 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 10,000 | $0.00 |
| 2013-06-11 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 9,375 | $23.76 |
| 2013-06-11 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 9,375 | $15.75 |
| 2013-06-11 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 売却 | 9,375 | $0.00 |
| 2013-05-30 | MUTO, FREDERICK T | Director | 普通株式 | 売却 | 10,000 | $21.96 |
| 2013-05-30 | MUTO, FREDERICK T | Director | 普通株式 | 購入 | 10,000 | $5.17 |
| 2013-05-30 | MUTO, FREDERICK T | Director | ストックオプション | 売却 | 10,000 | $0.00 |
| 2013-05-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 23,800 | $6.81 |
| 2013-05-01 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 6,145 | $0.00 |
| 2013-05-01 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 23,800 | $0.00 |
| 2013-05-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 6,145 | $22.26 |
| 2013-05-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 23,800 | $22.26 |
| 2013-05-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 6,145 | $11.12 |
| 2013-04-30 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 30,000 | $22.51 |
| 2013-04-30 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 30,000 | $0.00 |
| 2013-04-30 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 30,000 | $11.12 |
| 2013-04-25 | PARSHALL, B LYNNE | Director, COO, Secretary | ストックオプション | 売却 | 18,400 | $0.00 |
| 2013-04-25 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 売却 | 18,400 | $22.50 |
| 2013-04-25 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 7,454 | $11.12 |
| 2013-04-25 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 18,400 | $6.81 |
| 2013-04-25 | PARSHALL, B LYNNE | Director, COO, Secretary | ストックオプション | 売却 | 7,454 | $0.00 |
| 2013-04-25 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 売却 | 7,454 | $22.50 |
| 2013-04-24 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 10,417 | $0.00 |
| 2013-04-24 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 売却 | 30,000 | $22.12 |
| 2013-04-24 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 10,417 | $22.38 |
| 2013-04-24 | PARSHALL, B LYNNE | Director, COO, Secretary | ストックオプション | 売却 | 30,000 | $0.00 |
| 2013-04-24 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 10,000 | $22.12 |
| 2013-04-24 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 30,000 | $11.12 |
| 2013-04-24 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 10,417 | $15.38 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 6,000 | $22.13 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 3,900 | $0.00 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 6,000 | $15.38 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 2,260 | $0.00 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 2,700 | $0.00 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 2,260 | $14.47 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 10,660 | $22.13 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 10,660 | $0.00 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 10,660 | $14.18 |
| 2013-04-23 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 10,000 | $11.12 |
| 2013-04-23 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 売却 | 10,000 | $22.10 |
| 2013-04-23 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 10,000 | $6.81 |
| 2013-04-23 | PARSHALL, B LYNNE | Director, COO, Secretary | ストックオプション | 売却 | 10,000 | $0.00 |
| 2013-04-23 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 30,000 | $22.10 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 2,260 | $22.13 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 2,700 | $11.27 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 2,700 | $22.13 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,800 | $8.00 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,800 | $22.13 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 3,900 | $10.29 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 3,900 | $22.13 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,800 | $0.00 |
| 2013-04-23 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 6,000 | $0.00 |
| 2013-04-22 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 17,000 | $11.12 |
| 2013-04-22 | PARSHALL, B LYNNE | Director, COO, Secretary | ストックオプション | 売却 | 30,000 | $0.00 |
| 2013-04-22 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 7,813 | $0.00 |
| 2013-04-22 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 2,813 | $21.40 |
| 2013-04-22 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 3,000 | $15.38 |
| 2013-04-22 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 3,000 | $21.41 |
| 2013-04-22 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 売却 | 30,000 | $20.99 |
| 2013-04-22 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 30,000 | $11.12 |
| 2013-04-22 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | ストックオプション | 売却 | 9,843 | $0.00 |
| 2013-04-22 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 2,000 | $15.38 |
| 2013-04-22 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 2,000 | $21.43 |
| 2013-04-22 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 9,843 | $21.49 |
| 2013-04-22 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 2,813 | $15.38 |
| 2013-04-22 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 9,843 | $14.47 |
| 2013-04-22 | CROOKE, STANLEY T | Director, Chairman, CEO and President | ストックオプション | 売却 | 20,000 | $0.00 |
| 2013-04-22 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 10,000 | $20.99 |
| 2013-04-22 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 20,000 | $20.99 |
| 2013-04-22 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 20,000 | $7.26 |
| 2013-04-22 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 売却 | 17,000 | $0.00 |
| 2013-04-22 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 17,000 | $21.26 |
| 2013-04-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 6,000 | $0.00 |
| 2013-04-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 3,000 | $15.38 |
| 2013-04-19 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 30,000 | $7.26 |
| 2013-04-19 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 売却 | 30,000 | $20.01 |
| 2013-04-19 | PARSHALL, B LYNNE | Director, COO, Secretary | ストックオプション | 売却 | 30,000 | $0.00 |
| 2013-04-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 2,500 | $11.12 |
| 2013-04-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 2,500 | $21.25 |
| 2013-04-19 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 売却 | 2,500 | $0.00 |
| 2013-04-19 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 30,000 | $7.26 |
| 2013-04-19 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 30,000 | $20.01 |
| 2013-04-19 | CROOKE, STANLEY T | Director, Chairman, CEO and President | ストックオプション | 売却 | 30,000 | $0.00 |
| 2013-04-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 8,000 | $0.00 |
| 2013-04-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,000 | $0.00 |
| 2013-04-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,000 | $19.60 |
| 2013-04-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 6,000 | $14.47 |
| 2013-04-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 6,000 | $20.01 |
| 2013-04-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 5,000 | $15.38 |
| 2013-04-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 5,000 | $21.01 |
| 2013-04-19 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 2,042 | $11.12 |
| 2013-04-19 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 2,042 | $20.80 |
| 2013-04-19 | GEARY, RICHARD S | SVP, Development | ストックオプション | 売却 | 2,042 | $0.00 |
| 2013-04-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,000 | $14.18 |
| 2013-04-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 3,000 | $20.25 |
| 2013-04-12 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 売却 | 1,130 | $0.00 |
| 2013-04-12 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 4,330 | $14.18 |
| 2013-04-12 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 4,330 | $19.62 |
| 2013-04-12 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 売却 | 4,330 | $0.00 |
| 2013-04-12 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 1,130 | $14.47 |
| 2013-04-12 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 1,130 | $19.60 |
| 2013-04-11 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 購入 | 7,000 | $11.12 |
| 2013-04-11 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 売却 | 7,000 | $19.52 |
| 2013-04-11 | GEARY, RICHARD S | Sr VP, Development | ストックオプション | 売却 | 7,000 | $0.00 |
| 2013-03-21 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 売却 | 1,000 | $19.50 |
| 2013-03-21 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 9,000 | $14.18 |
| 2013-03-21 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 9,000 | $19.26 |
| 2013-03-21 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 売却 | 9,000 | $0.00 |
| 2013-03-21 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 購入 | 1,000 | $11.12 |
| 2013-03-21 | GEARY, RICHARD S | Sr VP, Development | ストックオプション | 売却 | 1,000 | $0.00 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 4,167 | $9.77 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 4,167 | $18.00 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,500 | $16.32 |
| 2013-03-20 | HOUGEN, ELIZABETH L | SVP, Finance and CFO | ストックオプション | 売却 | 4,792 | $0.00 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 3,750 | $0.00 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 4,166 | $0.00 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 2,500 | $0.00 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 2,500 | $18.00 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 1,250 | $9.22 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 1,250 | $18.00 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 1,250 | $0.00 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 4,167 | $0.00 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 173 | $0.00 |
| 2013-03-20 | HOUGEN, ELIZABETH L | SVP, Finance and CFO | 普通株式 | 購入 | 9,584 | $11.12 |
| 2013-03-20 | HOUGEN, ELIZABETH L | SVP, Finance and CFO | 普通株式 | 売却 | 9,584 | $18.13 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 174 | $5.93 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 174 | $18.00 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 174 | $0.00 |
| 2013-03-20 | HOUGEN, ELIZABETH L | SVP, Finance and CFO | ストックオプション | 売却 | 9,584 | $0.00 |
| 2013-03-20 | HOUGEN, ELIZABETH L | SVP, Finance and CFO | 普通株式 | 購入 | 4,792 | $11.12 |
| 2013-03-20 | HOUGEN, ELIZABETH L | SVP, Finance and CFO | 普通株式 | 売却 | 4,792 | $18.13 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 3,750 | $13.88 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 3,750 | $18.00 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 4,166 | $9.77 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 4,166 | $18.00 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 173 | $5.93 |
| 2013-03-20 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 173 | $18.00 |
| 2013-03-19 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 3,727 | $5.93 |
| 2013-03-19 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 3,726 | $0.00 |
| 2013-03-19 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 3,727 | $0.00 |
| 2013-03-19 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 3,726 | $5.93 |
| 2013-03-19 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 3,726 | $18.00 |
| 2013-03-19 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 3,727 | $18.00 |
| 2013-03-13 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 266 | $18.01 |
| 2013-03-13 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 6,667 | $0.00 |
| 2013-03-13 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 6,666 | $5.17 |
| 2013-03-13 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 266 | $0.00 |
| 2013-03-13 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 6,666 | $0.00 |
| 2013-03-13 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 268 | $5.93 |
| 2013-03-13 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 268 | $0.00 |
| 2013-03-13 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 6,667 | $5.17 |
| 2013-03-13 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 268 | $18.01 |
| 2013-03-13 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 6,667 | $18.01 |
| 2013-03-13 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 6,666 | $18.01 |
| 2013-03-13 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 266 | $5.93 |
| 2013-03-05 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 18,240 | $6.81 |
| 2013-03-05 | HOUGEN, ELIZABETH L | SVP, Finance and CFO | ストックオプション | 売却 | 5,040 | $0.00 |
| 2013-03-05 | HOUGEN, ELIZABETH L | SVP, Finance and CFO | 普通株式 | 売却 | 5,040 | $16.86 |
| 2013-03-05 | HOUGEN, ELIZABETH L | SVP, Finance and CFO | 普通株式 | 購入 | 5,040 | $6.81 |
| 2013-03-05 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 売却 | 18,240 | $0.00 |
| 2013-03-05 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 18,240 | $16.86 |
| 2013-03-04 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 売却 | 10,351 | $0.00 |
| 2013-03-04 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 売却 | 1,350 | $0.00 |
| 2013-03-04 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 1,350 | $11.12 |
| 2013-03-04 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 1,350 | $15.82 |
| 2013-03-04 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 10,350 | $15.82 |
| 2013-03-04 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 10,350 | $11.27 |
| 2013-02-21 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 10,000 | $5.17 |
| 2013-02-21 | BERTHELSEN, SPENCER R | Director | ストックオプション | 売却 | 10,000 | $0.00 |
| 2013-02-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 1,600 | $14.80 |
| 2013-02-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 1,600 | $10.29 |
| 2013-02-19 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 1,600 | $0.00 |
| 2013-02-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 100 | $14.80 |
| 2013-02-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 250 | $14.82 |
| 2013-02-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 100 | $10.29 |
| 2013-02-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 250 | $0.00 |
| 2013-02-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 250 | $10.29 |
| 2013-02-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 100 | $0.00 |
| 2013-02-13 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 900 | $0.00 |
| 2013-02-13 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | ストックオプション | 売却 | 5,200 | $0.00 |
| 2013-02-13 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 900 | $8.00 |
| 2013-02-13 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 900 | $14.17 |
| 2013-02-13 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 5,200 | $7.25 |
| 2013-02-13 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 5,200 | $14.17 |
| 2013-02-13 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 139 | $14.17 |
| 2013-01-30 | PARSHALL, B LYNNE | Director, COO, Secretary | ストックオプション | 購入 | 62,280 | $0.00 |
| 2013-01-30 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 購入 | 5,590 | $0.00 |
| 2013-01-30 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 購入 | 34,000 | $0.00 |
| 2013-01-30 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 購入 | 5,660 | $0.00 |
| 2013-01-30 | CROOKE, STANLEY T | Director, Chairman, CEO and President | ストックオプション | 購入 | 133,180 | $0.00 |
| 2013-01-30 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 譲渡制限付株式ユニット | 購入 | 22,190 | $0.00 |
| 2013-01-30 | MONIA, BRETT P | SVP, Antisense Drug Discovery | ストックオプション | 購入 | 34,000 | $0.00 |
| 2013-01-30 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 購入 | 5,660 | $0.00 |
| 2013-01-30 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 売却 | 2,000 | $0.00 |
| 2013-01-30 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 2,000 | $14.82 |
| 2013-01-30 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 2,000 | $10.29 |
| 2013-01-30 | PARSHALL, B LYNNE | Director, COO, Secretary | 譲渡制限付株式ユニット | 購入 | 10,380 | $0.00 |
| 2013-01-30 | GEARY, RICHARD S | SVP, Development | ストックオプション | 購入 | 33,540 | $0.00 |
| 2013-01-29 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 300 | $13.40 |
| 2013-01-17 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 売却 | 242 | $14.16 |
| 2013-01-16 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 1,317 | $14.00 |
| 2013-01-16 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 143 | $14.00 |
| 2013-01-16 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 235 | $14.00 |
| 2013-01-16 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 売却 | 759 | $14.00 |
| 2013-01-16 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 売却 | 242 | $14.00 |
| 2013-01-16 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 95 | $14.00 |
| 2013-01-16 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 309 | $14.00 |
| 2013-01-16 | GEARY, RICHARD S | SVP, Development | 普通株式 | 売却 | 345 | $14.00 |
| 2013-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 譲渡制限付株式ユニット | 売却 | 695 | $0.00 |
| 2013-01-15 | GEARY, RICHARD S | SVP, Development | 普通株式 | 購入 | 776 | $0.00 |
| 2013-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 普通株式 | 購入 | 542 | $0.00 |
| 2013-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 売却 | 542 | $0.00 |
| 2013-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 1,250 | $0.00 |
| 2013-01-15 | HOUGEN, ELIZABETH L | SVP, Finance & CFO | 譲渡制限付株式ユニット | 購入 | 2,615 | $0.00 |
| 2013-01-15 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 1,715 | $0.00 |
| 2013-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 普通株式 | 購入 | 542 | $0.00 |
| 2013-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 売却 | 542 | $0.00 |
| 2013-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 購入 | 1,250 | $0.00 |
| 2013-01-15 | O'NEIL, PATRICK R. | SVP, Legal & General Counsel | 譲渡制限付株式ユニット | 購入 | 2,615 | $0.00 |
| 2013-01-15 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 695 | $0.00 |
| 2013-01-15 | GEARY, RICHARD S | SVP, Development | 譲渡制限付株式ユニット | 売却 | 776 | $0.00 |
| 2013-01-15 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 2,978 | $0.00 |
| 2013-01-15 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 317 | $0.00 |
| 2013-01-15 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 譲渡制限付株式ユニット | 売却 | 2,978 | $0.00 |
| 2013-01-15 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 譲渡制限付株式ユニット | 売却 | 317 | $0.00 |
| 2013-01-15 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 譲渡制限付株式ユニット | 購入 | 1,666 | $0.00 |
| 2013-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 528 | $0.00 |
| 2013-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 209 | $0.00 |
| 2013-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 528 | $0.00 |
| 2013-01-15 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 譲渡制限付株式ユニット | 売却 | 209 | $0.00 |
| 2013-01-15 | PARSHALL, B LYNNE | Director, COO, Secretary | 譲渡制限付株式ユニット | 売却 | 1,715 | $0.00 |
| 2013-01-11 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2013-01-11 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 購入 | 10,000 | $0.00 |
| 2013-01-04 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 売却 | 1,296 | $10.76 |
| 2013-01-03 | MONIA, BRETT P | VP, Antisense Drug Discovery | 普通株式 | 売却 | 311 | $10.84 |
| 2013-01-03 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 売却 | 265 | $10.84 |
| 2013-01-02 | HOUGEN, ELIZABETH L | SVP, Finance and CFO | ストックオプション | 購入 | 7,500 | $0.00 |
| 2013-01-02 | CROOKE, STANLEY T | Director, COO, President | ストックオプション | 購入 | 10,000 | $0.00 |
| 2013-01-02 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 購入 | 15,700 | $0.00 |
| 2013-01-02 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | ストックオプション | 購入 | 7,500 | $0.00 |
| 2013-01-02 | HOUGEN, ELIZABETH L | SVP, Finance and CFO | ストックオプション | 購入 | 15,700 | $0.00 |
| 2013-01-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 447 | $8.87 |
| 2013-01-01 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 購入 | 898 | $8.87 |
| 2013-01-01 | O'NEIL, PATRICK R. | SVP, Legal and General Counsel | 普通株式 | 購入 | 431 | $8.87 |
| 2013-01-01 | MONIA, BRETT P | VP, Antisense Drug Discovery | 普通株式 | 購入 | 215 | $8.87 |
| 2012-12-13 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 売却 | 6,000 | $9.63 |
| 2012-12-13 | GEARY, RICHARD S | Sr VP, Development | ストックオプション | 売却 | 6,000 | $0.00 |
| 2012-12-13 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 購入 | 6,000 | $5.25 |
| 2012-10-10 | ISIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 購入 | 750,000 | $4.00 |
| 2012-10-10 | ISIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 売却 | 6,299,500 | $0.00 |
| 2012-10-10 | ISIS, PHARMACEUTICALS INC | 10% Owner | 普通株式 | 購入 | 6,299,500 | $ |
| 2012-09-21 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 29,462 | $14.06 |
| 2012-09-21 | CROOKE, STANLEY T | Director, Chairman, CEO and President | ストックオプション | 売却 | 29,462 | $0.00 |
| 2012-09-21 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 29,462 | $6.84 |
| 2012-09-20 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 20,538 | $15.01 |
| 2012-09-20 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 20,538 | $6.84 |
| 2012-09-20 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 9,462 | $15.01 |
| 2012-09-20 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 9,462 | $5.25 |
| 2012-09-20 | CROOKE, STANLEY T | Director, Chairman, CEO and President | ストックオプション | 売却 | 20,538 | $0.00 |
| 2012-09-20 | CROOKE, STANLEY T | Director, Chairman, CEO and President | ストックオプション | 売却 | 9,462 | $0.00 |
| 2012-09-19 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 30,000 | $14.82 |
| 2012-09-19 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 30,000 | $5.25 |
| 2012-09-19 | CROOKE, STANLEY T | Director, Chairman, CEO and President | ストックオプション | 売却 | 30,000 | $0.00 |
| 2012-09-13 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 27,074 | $5.25 |
| 2012-09-13 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 27,074 | $14.55 |
| 2012-09-13 | CROOKE, STANLEY T | Director, Chairman, CEO and President | ストックオプション | 売却 | 27,074 | $0.00 |
| 2012-09-07 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 5,000 | $6.84 |
| 2012-09-07 | PARSHALL, B LYNNE | Director, COO, Secretary | ストックオプション | 売却 | 2,506 | $0.00 |
| 2012-09-07 | PARSHALL, B LYNNE | Director, COO, Secretary | ストックオプション | 売却 | 5,000 | $0.00 |
| 2012-09-07 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 売却 | 2,506 | $15.12 |
| 2012-09-07 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 2,506 | $6.84 |
| 2012-09-07 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 売却 | 5,000 | $15.12 |
| 2012-09-06 | CROOKE, STANLEY T | Director, Chairman, CEO and President | ストックオプション | 売却 | 4,687 | $0.00 |
| 2012-09-06 | CROOKE, STANLEY T | Director, Chairman, CEO and President | ストックオプション | 売却 | 6,000 | $0.00 |
| 2012-09-06 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 2,494 | $6.84 |
| 2012-09-06 | PARSHALL, B LYNNE | Director, COO, Secretary | ストックオプション | 売却 | 5,000 | $0.00 |
| 2012-09-06 | CROOKE, STANLEY T | Director, Chairman, CEO and President | ストックオプション | 売却 | 17,388 | $0.00 |
| 2012-09-06 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 6,000 | $15.00 |
| 2012-09-06 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 6,000 | $5.25 |
| 2012-09-06 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 306 | $15.00 |
| 2012-09-06 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 306 | $5.25 |
| 2012-09-06 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 4,381 | $15.04 |
| 2012-09-06 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 4,381 | $5.25 |
| 2012-09-06 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 1,925 | $15.04 |
| 2012-09-06 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 1,925 | $6.84 |
| 2012-09-06 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 8,694 | $15.04 |
| 2012-09-06 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 8,694 | $15.00 |
| 2012-09-06 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 8,694 | $5.25 |
| 2012-09-06 | MONIA, BRETT P | VP, Antisense Drug Discovery | ストックオプション | 売却 | 12,031 | $0.00 |
| 2012-09-06 | MONIA, BRETT P | VP, Antisense Drug Discovery | 普通株式 | 売却 | 12,031 | $15.25 |
| 2012-09-06 | MONIA, BRETT P | VP, Antisense Drug Discovery | 普通株式 | 購入 | 12,031 | $5.25 |
| 2012-09-06 | REED, JOHN C | Director | ストックオプション | 売却 | 4,900 | $0.00 |
| 2012-09-06 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 売却 | 2,494 | $15.04 |
| 2012-09-06 | REED, JOHN C | Director | 普通株式 | 売却 | 4,900 | $15.18 |
| 2012-09-06 | REED, JOHN C | Director | 普通株式 | 購入 | 4,900 | $5.17 |
| 2012-09-06 | PARSHALL, B LYNNE | Director, COO, Secretary | ストックオプション | 売却 | 7,506 | $0.00 |
| 2012-09-06 | PARSHALL, B LYNNE | Director, COO, Secretary | ストックオプション | 売却 | 2,494 | $0.00 |
| 2012-09-06 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 売却 | 5,000 | $15.04 |
| 2012-09-06 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 5,000 | $6.84 |
| 2012-09-06 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 売却 | 5,000 | $15.00 |
| 2012-09-06 | CROOKE, STANLEY T | Director, Chairman, CEO and President | ストックオプション | 売却 | 1,925 | $0.00 |
| 2012-09-06 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 5,000 | $5.25 |
| 2012-09-06 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 売却 | 2,506 | $15.04 |
| 2012-09-06 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 2,506 | $5.25 |
| 2012-09-05 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 2,000 | $5.25 |
| 2012-09-05 | PARSHALL, B LYNNE | Director, COO, Secretary | ストックオプション | 売却 | 2,000 | $0.00 |
| 2012-09-05 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 15,000 | $5.25 |
| 2012-09-05 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 15,000 | $14.82 |
| 2012-09-05 | CROOKE, STANLEY T | Director, Chairman, CEO and President | ストックオプション | 売却 | 15,000 | $0.00 |
| 2012-09-05 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 売却 | 2,000 | $15.00 |
| 2012-09-04 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 売却 | 10,000 | $15.00 |
| 2012-09-04 | CROOKE, STANLEY T | Director, Chairman, CEO and President | ストックオプション | 売却 | 30,000 | $0.00 |
| 2012-09-04 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 売却 | 30,000 | $14.11 |
| 2012-09-04 | CROOKE, STANLEY T | Director, Chairman, CEO and President | 普通株式 | 購入 | 30,000 | $5.25 |
| 2012-09-04 | REED, JOHN C | Director | ストックオプション | 売却 | 5,100 | $0.00 |
| 2012-09-04 | REED, JOHN C | Director | 普通株式 | 売却 | 5,100 | $15.17 |
| 2012-09-04 | PARSHALL, B LYNNE | Director, COO, Secretary | ストックオプション | 売却 | 10,000 | $0.00 |
| 2012-09-04 | PARSHALL, B LYNNE | Director, COO, Secretary | 普通株式 | 購入 | 10,000 | $5.25 |
| 2012-09-04 | REED, JOHN C | Director | 普通株式 | 購入 | 5,100 | $5.17 |
| 2012-07-09 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 売却 | 2,686 | $13.47 |
| 2012-07-09 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 5,000 | $0.00 |
| 2012-07-09 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 5,500 | $0.00 |
| 2012-07-09 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 購入 | 1,000 | $5.25 |
| 2012-07-09 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 売却 | 1,000 | $13.45 |
| 2012-07-09 | REED, JOHN C | Director | ストックオプション | 売却 | 10,000 | $0.00 |
| 2012-07-09 | REED, JOHN C | Director | 普通株式 | 購入 | 10,000 | $3.95 |
| 2012-07-09 | GEARY, RICHARD S | Sr VP, Development | ストックオプション | 売却 | 5,686 | $0.00 |
| 2012-07-09 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 5,000 | $13.51 |
| 2012-07-09 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 5,000 | $6.81 |
| 2012-07-09 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 5,500 | $13.51 |
| 2012-07-09 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 5,500 | $6.84 |
| 2012-07-09 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 購入 | 2,686 | $5.25 |
| 2012-07-09 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 購入 | 2,000 | $5.25 |
| 2012-07-09 | REED, JOHN C | Director | 普通株式 | 売却 | 10,000 | $13.99 |
| 2012-07-09 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 売却 | 2,000 | $13.49 |
| 2012-07-03 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 売却 | 2,434 | $12.91 |
| 2012-07-03 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 売却 | 587 | $12.92 |
| 2012-07-03 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 6,000 | $6.84 |
| 2012-07-03 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 売却 | 6,000 | $12.91 |
| 2012-07-03 | BENNETT, C FRANK | SVP, Antisense Research | ストックオプション | 売却 | 6,000 | $0.00 |
| 2012-07-02 | MUTO, FREDERICK T | Director | 譲渡制限付株式ユニット | 購入 | 1,250 | $0.00 |
| 2012-07-02 | REED, JOHN C | Director | ストックオプション | 購入 | 11,250 | $0.00 |
| 2012-07-02 | REED, JOHN C | Director | 譲渡制限付株式ユニット | 購入 | 1,250 | $0.00 |
| 2012-07-02 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 11,250 | $0.00 |
| 2012-07-02 | WENDER, JOSEPH H | Director | 譲渡制限付株式ユニット | 購入 | 1,250 | $0.00 |
| 2012-07-02 | KLEIN, JOSEPH III | Director | 譲渡制限付株式ユニット | 購入 | 1,250 | $0.00 |
| 2012-07-02 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 11,250 | $0.00 |
| 2012-07-02 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 11,250 | $0.00 |
| 2012-07-02 | BERTHELSEN, SPENCER R | Director | 譲渡制限付株式ユニット | 購入 | 1,250 | $0.00 |
| 2012-07-02 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 11,250 | $0.00 |
| 2012-07-01 | MONIA, BRETT P | SVP, Antisense Drug Discovery | 普通株式 | 購入 | 311 | $6.13 |
| 2012-07-01 | BENNETT, C FRANK | SVP, Antisense Research | 普通株式 | 購入 | 648 | $6.13 |
| 2012-07-01 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 購入 | 1,300 | $6.13 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 228 | $11.53 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 300 | $11.49 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 300 | $8.15 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 300 | $11.48 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 200 | $8.15 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 200 | $11.49 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 200 | $11.50 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 500 | $8.15 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 500 | $11.51 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 228 | $8.15 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 205 | $8.15 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 205 | $11.54 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 495 | $8.15 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 495 | $11.55 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 700 | $8.15 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 700 | $11.56 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 3,500 | $8.15 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 3,500 | $11.58 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 1,500 | $8.15 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 1,500 | $11.58 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 100 | $8.15 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 100 | $11.59 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 1,600 | $8.15 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 1,600 | $11.60 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 172 | $8.15 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 172 | $11.62 |
| 2012-06-25 | BERTHELSEN, SPENCER R | Director | ストックオプション | 売却 | 10,000 | $0.00 |
| 2012-06-22 | REED, JOHN C | Director | ストックオプション | 売却 | 10,000 | $0.00 |
| 2012-06-22 | REED, JOHN C | Director | 普通株式 | 購入 | 10,000 | $8.15 |
| 2012-06-22 | REED, JOHN C | Director | 普通株式 | 売却 | 10,000 | $11.06 |
| 2012-06-14 | GEARY, RICHARD S | Sr VP, Development | 普通株式 | 売却 | 1,579 | $10.86 |
| 2012-06-12 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 10,000 | $8.15 |
| 2012-06-12 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 10,000 | $0.00 |
| 2012-05-22 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 17,269 | $9.40 |
| 2012-05-22 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 17,269 | $9.56 |
| 2012-05-22 | BERTHELSEN, SPENCER R | Director | ストックオプション | 売却 | 17,269 | $0.00 |
| 2012-05-21 | BERTHELSEN, SPENCER R | Director | ストックオプション | 売却 | 2,731 | $0.00 |
| 2012-05-21 | BERTHELSEN, SPENCER R | Director | 普通株式 | 購入 | 2,731 | $9.40 |
| 2012-05-21 | BERTHELSEN, SPENCER R | Director | 普通株式 | 売却 | 2,731 | $9.42 |
| 2012-01-15 | GEARY, RICHARD S | Senior Vice President | 譲渡制限付株式ユニット | 購入 | 3,103 | $0.00 |
| 2012-01-15 | MONIA, BRETT P | Senior Vice President | 譲渡制限付株式ユニット | 購入 | 2,110 | $0.00 |
| 2012-01-15 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 譲渡制限付株式ユニット | 購入 | 1,266 | $0.00 |
| 2012-01-15 | BENNETT, C FRANK | Senior Vice President | 譲渡制限付株式ユニット | 購入 | 2,778 | $0.00 |
| 2012-01-15 | PARSHALL, B LYNNE | Director, Director, COO | 譲渡制限付株式ユニット | 購入 | 6,860 | $0.00 |
| 2012-01-15 | MONIA, BRETT P | Senior Vice President | 譲渡制限付株式ユニット | 購入 | 833 | $0.00 |
| 2012-01-15 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 譲渡制限付株式ユニット | 購入 | 11,910 | $0.00 |
| 2012-01-13 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 購入 | 10,000 | $0.00 |
| 2012-01-13 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2012-01-04 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 7,500 | $0.00 |
| 2012-01-04 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 3,750 | $0.00 |
| 2012-01-04 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 4,166 | $0.00 |
| 2012-01-04 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 3,750 | $0.00 |
| 2012-01-04 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 2,500 | $0.00 |
| 2012-01-04 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 11,250 | $0.00 |
| 2012-01-04 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 12,500 | $0.00 |
| 2012-01-04 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 4,167 | $0.00 |
| 2012-01-04 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 1,250 | $0.00 |
| 2012-01-03 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 購入 | 25,013 | $0.00 |
| 2012-01-03 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 11,404 | $0.00 |
| 2012-01-03 | MONIA, BRETT P | Director, Senior Vice President | ストックオプション | 購入 | 18,993 | $0.00 |
| 2012-01-03 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 107,203 | $0.00 |
| 2012-01-03 | GEARY, RICHARD S | Senior Vice President | ストックオプション | 購入 | 27,935 | $0.00 |
| 2012-01-03 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 購入 | 61,749 | $0.00 |
| 2012-01-01 | MONIA, BRETT P | Director, Senior Vice President | 普通株式 | 売却 | 587 | $6.13 |
| 2012-01-01 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 324 | $6.13 |
| 2012-01-01 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 1,625 | $6.13 |
| 2012-01-01 | MONIA, BRETT P | Director, Senior Vice President | ストックオプション | 購入 | 7,500 | $0.00 |
| 2011-12-30 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 6,667 | $0.00 |
| 2011-12-30 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 4,166 | $0.00 |
| 2011-12-30 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 20,000 | $0.00 |
| 2011-12-30 | KLEIN, JOSEPH III | Director | ストックオプション | 売却 | 12,500 | $0.00 |
| 2011-12-30 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 6,666 | $0.00 |
| 2011-12-30 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 4,167 | $0.00 |
| 2011-12-21 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 売却 | 1,144 | $6.92 |
| 2011-12-21 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 1,555 | $0.00 |
| 2011-12-21 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 1,555 | $6.92 |
| 2011-12-21 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 1,555 | $5.80 |
| 2011-12-21 | GEARY, RICHARD S | Senior Vice President | ストックオプション | 売却 | 1,144 | $0.00 |
| 2011-12-21 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 2,363 | $6.92 |
| 2011-12-21 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 2,200 | $5.80 |
| 2011-12-21 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 2,200 | $6.92 |
| 2011-12-21 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 2,363 | $0.00 |
| 2011-12-21 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 2,200 | $0.00 |
| 2011-12-21 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 16,720 | $6.92 |
| 2011-12-21 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 16,720 | $0.00 |
| 2011-12-21 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 1,080 | $0.00 |
| 2011-12-21 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 2,363 | $5.80 |
| 2011-12-21 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 16,720 | $5.80 |
| 2011-12-21 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 1,080 | $5.80 |
| 2011-12-21 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 1,080 | $6.92 |
| 2011-12-21 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 1,144 | $5.80 |
| 2011-12-20 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 300 | $5.80 |
| 2011-12-20 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 700 | $6.92 |
| 2011-12-20 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 2,800 | $5.80 |
| 2011-12-20 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 700 | $5.80 |
| 2011-12-20 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 300 | $6.92 |
| 2011-12-20 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 2,000 | $5.80 |
| 2011-12-20 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 2,000 | $6.82 |
| 2011-12-20 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 500 | $5.80 |
| 2011-12-20 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 500 | $6.92 |
| 2011-12-20 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 22,000 | $5.80 |
| 2011-12-20 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 22,000 | $6.82 |
| 2011-12-20 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 5,000 | $5.80 |
| 2011-12-20 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 5,000 | $6.92 |
| 2011-12-20 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 2,500 | $0.00 |
| 2011-12-20 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 3,600 | $0.00 |
| 2011-12-20 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 3,500 | $0.00 |
| 2011-12-20 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 1,700 | $0.00 |
| 2011-12-20 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 27,000 | $0.00 |
| 2011-12-20 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 1,400 | $6.82 |
| 2011-12-20 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 1,400 | $5.80 |
| 2011-12-20 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 2,800 | $6.82 |
| 2011-12-20 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 1,500 | $5.80 |
| 2011-12-20 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 売却 | 1,500 | $6.82 |
| 2011-12-20 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 300 | $5.80 |
| 2011-12-20 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 売却 | 300 | $6.92 |
| 2011-12-20 | GEARY, RICHARD S | Senior Vice President | ストックオプション | 売却 | 1,800 | $0.00 |
| 2011-12-20 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 2,900 | $5.80 |
| 2011-12-20 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 2,900 | $6.82 |
| 2011-12-19 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 160 | $5.80 |
| 2011-12-19 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 246 | $5.80 |
| 2011-12-19 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 246 | $6.90 |
| 2011-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 118 | $6.90 |
| 2011-12-19 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 1,500 | $0.00 |
| 2011-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 982 | $5.80 |
| 2011-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 982 | $6.82 |
| 2011-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 1,100 | $0.00 |
| 2011-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 17,000 | $0.00 |
| 2011-12-19 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 売却 | 118 | $6.90 |
| 2011-12-19 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 2,300 | $0.00 |
| 2011-12-19 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 1,340 | $6.82 |
| 2011-12-19 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 2,000 | $5.80 |
| 2011-12-19 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 2,054 | $580.00 |
| 2011-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 1,822 | $5.80 |
| 2011-12-19 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 982 | $5.80 |
| 2011-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 15,178 | $5.80 |
| 2011-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 15,178 | $6.82 |
| 2011-12-19 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 118 | $5.80 |
| 2011-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 1,822 | $6.90 |
| 2011-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 118 | $5.80 |
| 2011-12-19 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 2,054 | $5.80 |
| 2011-12-19 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 売却 | 982 | $6.82 |
| 2011-12-19 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 2,054 | $6.82 |
| 2011-12-19 | GEARY, RICHARD S | Senior Vice President | ストックオプション | 売却 | 1,100 | $0.00 |
| 2011-12-19 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 1,340 | $5.80 |
| 2011-12-19 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 160 | $6.90 |
| 2011-12-16 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 1,000 | $5.80 |
| 2011-12-16 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 1,500 | $6.79 |
| 2011-12-16 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 2,000 | $6.79 |
| 2011-12-16 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 2,000 | $0.00 |
| 2011-12-16 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 2,000 | $5.80 |
| 2011-12-16 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 1,500 | $5.80 |
| 2011-12-16 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 15,000 | $6.79 |
| 2011-12-16 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 15,000 | $5.80 |
| 2011-12-16 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 1,500 | $5.80 |
| 2011-12-16 | GEARY, RICHARD S | Senior Vice President | ストックオプション | 売却 | 1,000 | $0.00 |
| 2011-12-16 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 1,500 | $0.00 |
| 2011-12-16 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 15,000 | $0.00 |
| 2011-12-16 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 1,500 | $0.00 |
| 2011-12-16 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 1,500 | $6.79 |
| 2011-12-16 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 売却 | 1,000 | $6.79 |
| 2011-12-01 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 324 | $6.13 |
| 2011-10-24 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2011-10-24 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 購入 | 10,000 | $0.00 |
| 2011-08-04 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 10,000 | $5.25 |
| 2011-08-04 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 10,000 | $7.62 |
| 2011-08-04 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 10,000 | $0.00 |
| 2011-07-28 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 1,000 | $8.60 |
| 2011-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2011-07-01 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 265 | $7.91 |
| 2011-07-01 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2011-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2011-07-01 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 251 | $7.91 |
| 2011-07-01 | REED, JOHN C | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2011-07-01 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2011-01-03 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 購入 | 27,250 | $0.00 |
| 2011-01-03 | GEARY, RICHARD S | Senior Vice President | ストックオプション | 購入 | 33,444 | $0.00 |
| 2011-01-03 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 15,000 | $0.00 |
| 2011-01-03 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 122,096 | $0.00 |
| 2011-01-03 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 購入 | 72,884 | $0.00 |
| 2011-01-01 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 2,434 | $7.79 |
| 2011-01-01 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 493 | $7.79 |
| 2010-12-29 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 6,400 | $0.00 |
| 2010-12-29 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 2,000 | $0.00 |
| 2010-12-29 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 4,600 | $0.00 |
| 2010-12-29 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 4,600 | $10.32 |
| 2010-12-29 | GEARY, RICHARD S | Senior Vice President | ストックオプション | 売却 | 1,980 | $0.00 |
| 2010-12-29 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 売却 | 1,980 | $10.32 |
| 2010-12-29 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 1,980 | $9.63 |
| 2010-12-29 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 2,000 | $9.63 |
| 2010-12-29 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 4,600 | $9.63 |
| 2010-12-29 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 10,000 | $9.63 |
| 2010-12-29 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 10,000 | $10.32 |
| 2010-12-29 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2010-12-29 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 2,000 | $10.32 |
| 2010-12-29 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 6,400 | $10.32 |
| 2010-12-29 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 6,400 | $9.63 |
| 2010-12-27 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 10,800 | $0.00 |
| 2010-12-27 | GEARY, RICHARD S | Senior Vice President | ストックオプション | 売却 | 3,300 | $0.00 |
| 2010-12-27 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 7,700 | $10.42 |
| 2010-12-27 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 10,800 | $10.42 |
| 2010-12-27 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 10,800 | $9.63 |
| 2010-12-27 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 7,700 | $9.63 |
| 2010-12-27 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 20,000 | $10.42 |
| 2010-12-27 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 20,000 | $9.63 |
| 2010-12-27 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 売却 | 3,300 | $10.42 |
| 2010-12-27 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 7,700 | $0.00 |
| 2010-12-27 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 3,300 | $9.63 |
| 2010-12-27 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2010-12-23 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 4,000 | $9.63 |
| 2010-12-23 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 800 | $9.63 |
| 2010-12-23 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 800 | $10.53 |
| 2010-12-23 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 650 | $0.00 |
| 2010-12-23 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 800 | $0.00 |
| 2010-12-23 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 400 | $9.63 |
| 2010-12-23 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 売却 | 400 | $10.53 |
| 2010-12-23 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 1,500 | $9.63 |
| 2010-12-23 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 1,500 | $10.53 |
| 2010-12-23 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 1,500 | $0.00 |
| 2010-12-23 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 4,000 | $0.00 |
| 2010-12-23 | GEARY, RICHARD S | Senior Vice President | ストックオプション | 売却 | 400 | $0.00 |
| 2010-12-23 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 650 | $10.53 |
| 2010-12-23 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 4,000 | $10.53 |
| 2010-12-23 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 200 | $9.63 |
| 2010-12-23 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 売却 | 200 | $10.53 |
| 2010-12-23 | GEARY, RICHARD S | Senior Vice President | ストックオプション | 売却 | 200 | $0.00 |
| 2010-12-23 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 650 | $9.63 |
| 2010-12-22 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 売却 | 4,350 | $10.52 |
| 2010-12-22 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 6,200 | $10.52 |
| 2010-12-22 | GEARY, RICHARD S | Senior Vice President | ストックオプション | 売却 | 2,600 | $0.00 |
| 2010-12-22 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 16,000 | $0.00 |
| 2010-12-22 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 16,000 | $10.52 |
| 2010-12-22 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 16,000 | $9.63 |
| 2010-12-22 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 売却 | 2,600 | $10.52 |
| 2010-12-22 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 6,200 | $9.63 |
| 2010-12-22 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 2,600 | $9.63 |
| 2010-12-22 | PARSHALL, B LYNNE | Director, COO | ストックオプション | 売却 | 4,350 | $0.00 |
| 2010-12-22 | PARSHALL, B LYNNE | Director, COO | 普通株式 | 購入 | 4,350 | $9.63 |
| 2010-12-22 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 6,200 | $0.00 |
| 2010-07-23 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 1,100 | $9.60 |
| 2010-07-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 18,750 | $0.00 |
| 2010-07-01 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2010-07-01 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 490 | $7.84 |
| 2010-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2010-07-01 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2010-07-01 | DIMARCHI, RICHARD D | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2010-07-01 | REED, JOHN C | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2010-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2010-06-30 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 1,000 | $9.75 |
| 2010-06-30 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 1,000 | $0.00 |
| 2010-06-30 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 1,000 | $5.80 |
| 2010-06-29 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 3,000 | $9.71 |
| 2010-06-29 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 3,000 | $0.00 |
| 2010-06-29 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 3,000 | $5.80 |
| 2010-06-28 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 6,000 | $10.01 |
| 2010-06-28 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 6,000 | $5.80 |
| 2010-06-28 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 6,000 | $0.00 |
| 2010-01-29 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 購入 | 5,000 | $0.00 |
| 2010-01-29 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2010-01-04 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 購入 | 27,805 | $0.00 |
| 2010-01-04 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 6,600 | $0.00 |
| 2010-01-04 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 119,163 | $0.00 |
| 2010-01-04 | GEARY, RICHARD S | Senior Vice President | ストックオプション | 購入 | 32,640 | $0.00 |
| 2010-01-04 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 購入 | 63,554 | $0.00 |
| 2010-01-01 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 195 | $9.44 |
| 2010-01-01 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 1,579 | $9.44 |
| 2009-12-31 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 3,545 | $11.21 |
| 2009-12-31 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 3,545 | $6.81 |
| 2009-12-31 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 3,545 | $0.00 |
| 2009-12-30 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 10,000 | $6.81 |
| 2009-12-30 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 6,535 | $6.81 |
| 2009-12-30 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 10,000 | $0.00 |
| 2009-12-30 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 6,535 | $11.07 |
| 2009-12-30 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 3,000 | $6.81 |
| 2009-12-30 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 6,535 | $0.00 |
| 2009-12-30 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 3,000 | $11.07 |
| 2009-12-30 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 3,000 | $0.00 |
| 2009-12-28 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 1,000 | $11.17 |
| 2009-12-28 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2009-12-28 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 1,000 | $6.81 |
| 2009-12-23 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 7,500 | $10.59 |
| 2009-12-23 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 1,910 | $10.59 |
| 2009-12-23 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 7,500 | $6.81 |
| 2009-12-23 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 1,910 | $6.81 |
| 2009-12-23 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 7,500 | $0.00 |
| 2009-12-23 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 1,910 | $0.00 |
| 2009-12-22 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2009-12-22 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 10,000 | $6.81 |
| 2009-12-22 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2009-12-22 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 20,000 | $10.13 |
| 2009-12-22 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 20,000 | $6.81 |
| 2009-12-22 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 10,000 | $10.13 |
| 2009-12-16 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 23,465 | $6.81 |
| 2009-12-16 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 23,465 | $0.00 |
| 2009-12-16 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 23,465 | $10.11 |
| 2009-12-15 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 10,000 | $6.81 |
| 2009-12-15 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 1,000 | $6.25 |
| 2009-12-15 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 1,000 | $10.03 |
| 2009-12-15 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 1,000 | $0.00 |
| 2009-12-15 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 10,000 | $10.03 |
| 2009-12-15 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2009-12-15 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 26,535 | $6.81 |
| 2009-12-15 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 26,535 | $10.03 |
| 2009-12-15 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 26,535 | $0.00 |
| 2009-12-14 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 20,000 | $9.86 |
| 2009-12-14 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2009-12-14 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 20,000 | $6.81 |
| 2009-12-11 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 10,000 | $9.98 |
| 2009-12-11 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 20,000 | $9.98 |
| 2009-12-11 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2009-12-11 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 20,000 | $6.81 |
| 2009-12-11 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 10,000 | $6.81 |
| 2009-12-11 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2009-12-10 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 13,000 | $0.00 |
| 2009-12-10 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 13,000 | $6.81 |
| 2009-12-10 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 30,000 | $10.15 |
| 2009-12-10 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 30,000 | $0.00 |
| 2009-12-10 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 13,000 | $10.15 |
| 2009-12-10 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 30,000 | $6.81 |
| 2009-12-09 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2009-12-09 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 10,000 | $0.00 |
| 2009-12-09 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 10,000 | $10.26 |
| 2009-12-09 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 10,000 | $6.81 |
| 2009-12-09 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 20,000 | $6.81 |
| 2009-12-09 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 20,000 | $10.26 |
| 2009-12-08 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 30,000 | $10.53 |
| 2009-12-08 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 30,000 | $0.00 |
| 2009-12-08 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 20,000 | $10.53 |
| 2009-12-08 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 20,000 | $6.81 |
| 2009-12-08 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2009-12-08 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 30,000 | $6.81 |
| 2009-12-07 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 30,000 | $6.81 |
| 2009-12-07 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 25,000 | $0.00 |
| 2009-12-07 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 30,000 | $0.00 |
| 2009-12-07 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 25,000 | $6.81 |
| 2009-12-07 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 30,000 | $10.52 |
| 2009-12-07 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 25,000 | $10.52 |
| 2009-12-04 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 20,000 | $10.55 |
| 2009-12-04 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 20,000 | $6.81 |
| 2009-12-04 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 30,000 | $0.00 |
| 2009-12-04 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2009-12-04 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 30,000 | $10.55 |
| 2009-12-04 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 30,000 | $6.81 |
| 2009-07-23 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 12,000 | $6.81 |
| 2009-07-23 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 12,000 | $0.00 |
| 2009-07-23 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 12,000 | $17.03 |
| 2009-07-06 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 876 | $15.71 |
| 2009-07-02 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 売却 | 387 | $15.89 |
| 2009-07-01 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2009-07-01 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2009-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2009-07-01 | DIMARCHI, RICHARD D | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2009-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2009-07-01 | REED, JOHN C | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2009-07-01 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 387 | $12.30 |
| 2009-07-01 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 289 | $12.30 |
| 2009-04-22 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 10,000 | $15.92 |
| 2009-04-22 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 10,000 | $0.00 |
| 2009-04-22 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 10,000 | $6.81 |
| 2009-04-07 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 10,000 | $14.60 |
| 2009-04-07 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 10,000 | $0.00 |
| 2009-04-07 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 10,000 | $6.81 |
| 2009-01-05 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 1,949 | $14.20 |
| 2009-01-02 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 購入 | 78,229 | $0.00 |
| 2009-01-02 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 売却 | 1,415 | $14.05 |
| 2009-01-02 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 7,000 | $0.00 |
| 2009-01-02 | GEARY, RICHARD S | Senior Vice President | ストックオプション | 購入 | 28,960 | $0.00 |
| 2009-01-02 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 購入 | 32,909 | $0.00 |
| 2009-01-02 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 150,000 | $0.00 |
| 2009-01-01 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 700 | $11.65 |
| 2009-01-01 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 150 | $11.65 |
| 2009-01-01 | GEARY, RICHARD S | Senior Vice President | 普通株式 | 購入 | 1,415 | $11.65 |
| 2008-12-30 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 5,000 | $13.37 |
| 2008-12-30 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 7,500 | $13.37 |
| 2008-12-30 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 5,000 | $12.94 |
| 2008-12-30 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 5,000 | $0.00 |
| 2008-12-30 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 7,500 | $12.94 |
| 2008-12-30 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 7,500 | $0.00 |
| 2008-12-26 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 5,000 | $0.00 |
| 2008-12-26 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 5,000 | $12.94 |
| 2008-12-26 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 7,500 | $13.25 |
| 2008-12-26 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 7,500 | $0.00 |
| 2008-12-26 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 7,500 | $12.94 |
| 2008-12-26 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 5,000 | $13.25 |
| 2008-12-23 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 8,000 | $0.00 |
| 2008-12-23 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 1,800 | $13.52 |
| 2008-12-23 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 1,800 | $12.94 |
| 2008-12-23 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 7,000 | $13.52 |
| 2008-12-23 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 7,000 | $0.00 |
| 2008-12-23 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 7,000 | $12.94 |
| 2008-12-23 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 8,000 | $12.94 |
| 2008-12-23 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 8,000 | $13.52 |
| 2008-12-23 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 1,800 | $0.00 |
| 2008-12-19 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 8,000 | $0.00 |
| 2008-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 12,000 | $12.94 |
| 2008-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 1,000 | $13.93 |
| 2008-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 12,000 | $13.93 |
| 2008-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 1,000 | $0.00 |
| 2008-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 12,000 | $0.00 |
| 2008-12-19 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 1,000 | $12.94 |
| 2008-12-19 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 8,000 | $12.94 |
| 2008-12-19 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 8,000 | $13.93 |
| 2008-12-17 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 7,482 | $12.80 |
| 2008-12-17 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 4,691 | $0.00 |
| 2008-12-17 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 7,482 | $0.00 |
| 2008-12-17 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 4,691 | $12.80 |
| 2008-12-17 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 4,691 | $5.15 |
| 2008-12-17 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 7,482 | $5.15 |
| 2008-09-16 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 購入 | 30,000 | $0.00 |
| 2008-09-02 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 10,000 | $6.81 |
| 2008-09-02 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 10,000 | $18.11 |
| 2008-09-02 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 10,000 | $0.00 |
| 2008-08-22 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 10,000 | $18.04 |
| 2008-08-22 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 10,000 | $6.81 |
| 2008-08-22 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 10,000 | $0.00 |
| 2008-08-20 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 6,000 | $17.97 |
| 2008-08-20 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 6,000 | $0.00 |
| 2008-08-20 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 6,000 | $6.81 |
| 2008-08-16 | GEARY, RICHARD S | Senior Vice President | ストックオプション | 購入 | 10,000 | $0.00 |
| 2008-08-15 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 1,000 | $0.00 |
| 2008-08-15 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 1,000 | $6.25 |
| 2008-08-15 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 1,000 | $19.25 |
| 2008-08-14 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 7,000 | $6.25 |
| 2008-08-14 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 7,000 | $0.00 |
| 2008-08-14 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 7,000 | $19.26 |
| 2008-08-11 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 売却 | 15,000 | $0.00 |
| 2008-08-11 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 7,500 | $18.03 |
| 2008-08-11 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 7,500 | $18.52 |
| 2008-08-11 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 15,000 | $12.94 |
| 2008-08-11 | TREBLE, MICHAEL J | Vice President, Pres of Ibis | ストックオプション | 売却 | 20,000 | $0.00 |
| 2008-08-11 | TREBLE, MICHAEL J | Vice President, Pres of Ibis | 普通株式 | 売却 | 10,000 | $18.95 |
| 2008-08-11 | TREBLE, MICHAEL J | Vice President, Pres of Ibis | 普通株式 | 売却 | 10,000 | $17.96 |
| 2008-08-11 | TREBLE, MICHAEL J | Vice President, Pres of Ibis | 普通株式 | 購入 | 20,000 | $5.95 |
| 2008-08-11 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 15,000 | $0.00 |
| 2008-08-11 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 9,925 | $18.55 |
| 2008-08-11 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 5,075 | $18.03 |
| 2008-08-11 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 15,000 | $5.80 |
| 2008-08-11 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 5,200 | $18.55 |
| 2008-08-11 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 500 | $18.56 |
| 2008-08-11 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 800 | $18.58 |
| 2008-08-11 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 300 | $18.60 |
| 2008-08-11 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 200 | $18.62 |
| 2008-08-11 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 2,900 | $18.63 |
| 2008-08-11 | KLEIN, JOSEPH III | Director | 普通株式 | 売却 | 100 | $18.64 |
| 2008-07-03 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 4,000 | $13.94 |
| 2008-07-03 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 1,338 | $13.91 |
| 2008-07-01 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2008-07-01 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2008-07-01 | DIMARCHI, RICHARD D | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2008-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2008-07-01 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 145 | $11.80 |
| 2008-07-01 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 1,285 | $11.80 |
| 2008-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2008-07-01 | REED, JOHN C | Director | ストックオプション | 購入 | 15,000 | $0.00 |
| 2008-06-30 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 4,000 | $13.25 |
| 2008-06-30 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 4,000 | $0.00 |
| 2008-05-19 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 1,500 | $0.00 |
| 2008-04-10 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 5,300 | $0.00 |
| 2008-04-10 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 5,300 | $6.84 |
| 2008-04-10 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 5,300 | $16.04 |
| 2008-04-07 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 2,500 | $16.03 |
| 2008-04-07 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 7,200 | $0.00 |
| 2008-04-07 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 5,000 | $0.00 |
| 2008-04-07 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 2,500 | $16.08 |
| 2008-04-07 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 7,200 | $16.08 |
| 2008-04-07 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 5,000 | $5.80 |
| 2008-04-07 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 7,200 | $6.84 |
| 2008-04-01 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 10,000 | $5.25 |
| 2008-04-01 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 10,000 | $15.33 |
| 2008-04-01 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 売却 | 10,000 | $0.00 |
| 2008-01-08 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 売却 | 2,406 | $19.28 |
| 2008-01-04 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 3,000 | $0.00 |
| 2008-01-03 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 購入 | 10,000 | $0.00 |
| 2008-01-03 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2008-01-02 | ECKER, DAVID J | Vice President | ストックオプション | 購入 | 19,930 | $0.00 |
| 2008-01-02 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 190,495 | $0.00 |
| 2008-01-02 | JONAS, JEFFREY M | Executive Vice President | ストックオプション | 購入 | 78,936 | $0.00 |
| 2008-01-02 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 8,300 | $0.00 |
| 2008-01-02 | BENNETT, C FRANK | Senior Vice President | ストックオプション | 購入 | 46,200 | $0.00 |
| 2008-01-02 | PARSHALL, B LYNNE | Director, Director, COO | ストックオプション | 購入 | 91,520 | $0.00 |
| 2008-01-02 | TREBLE, MICHAEL J | Vice President, Pres of Ibis | ストックオプション | 購入 | 21,840 | $0.00 |
| 2008-01-01 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 2,065 | $8.30 |
| 2008-01-01 | PARSHALL, B LYNNE | Director, Director, COO | 普通株式 | 購入 | 876 | $8.30 |
| 2008-01-01 | BENNETT, C FRANK | Senior Vice President | 普通株式 | 購入 | 195 | $8.30 |
| 2007-12-28 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 2,000 | $0.00 |
| 2007-12-28 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 20,000 | $12.31 |
| 2007-12-28 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 20,000 | $16.22 |
| 2007-12-28 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 18,000 | $0.00 |
| 2007-12-27 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 2,100 | $12.31 |
| 2007-12-27 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 6,000 | $0.00 |
| 2007-12-27 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 2,100 | $0.00 |
| 2007-12-27 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 6,000 | $16.32 |
| 2007-12-27 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 6,000 | $12.31 |
| 2007-12-26 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 24,000 | $12.31 |
| 2007-12-26 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 24,000 | $0.00 |
| 2007-12-26 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 24,000 | $16.53 |
| 2007-12-11 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 20,000 | $12.31 |
| 2007-12-11 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 20,000 | $0.00 |
| 2007-12-11 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 20,000 | $17.37 |
| 2007-12-03 | XANTHOPOULOS, KLEANTHIS G | President of Regulus | ストックオプション | 購入 | 60,000 | $0.00 |
| 2007-11-30 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 29,851 | $18.03 |
| 2007-11-30 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 29,851 | $0.00 |
| 2007-11-30 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 29,851 | $5.15 |
| 2007-11-28 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 20,000 | $18.01 |
| 2007-11-28 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 購入 | 20,000 | $6.81 |
| 2007-11-28 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 30,000 | $5.15 |
| 2007-11-28 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 30,000 | $0.00 |
| 2007-11-28 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 30,000 | $18.01 |
| 2007-11-28 | PARSHALL, B LYNNE | Director, Executive Vice President | ストックオプション | 売却 | 20,000 | $0.00 |
| 2007-10-26 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 3,400 | $0.00 |
| 2007-10-01 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 購入 | 20,000 | $12.31 |
| 2007-10-01 | PARSHALL, B LYNNE | Director, Executive Vice President | ストックオプション | 売却 | 20,000 | $0.00 |
| 2007-10-01 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 20,000 | $15.23 |
| 2007-09-28 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 購入 | 5,000 | $12.31 |
| 2007-09-28 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 5,000 | $0.00 |
| 2007-09-28 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 5,000 | $15.03 |
| 2007-09-27 | PARSHALL, B LYNNE | Director, Executive Vice President | ストックオプション | 売却 | 20,000 | $0.00 |
| 2007-09-27 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 購入 | 20,000 | $12.31 |
| 2007-09-27 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 20,000 | $15.27 |
| 2007-09-21 | TREBLE, MICHAEL J | Vice President, Head of Ibis | ストックオプション | 売却 | 10,000 | $0.00 |
| 2007-09-21 | TREBLE, MICHAEL J | Vice President, Head of Ibis | 普通株式 | 購入 | 10,000 | $5.95 |
| 2007-09-21 | TREBLE, MICHAEL J | Vice President, Head of Ibis | 普通株式 | 売却 | 10,000 | $14.95 |
| 2007-09-20 | BENNETT, C FRANK | Vice President | ストックオプション | 売却 | 14,000 | $0.00 |
| 2007-09-20 | BENNETT, C FRANK | Vice President | 普通株式 | 売却 | 14,000 | $14.76 |
| 2007-09-20 | BENNETT, C FRANK | Vice President | 普通株式 | 購入 | 14,000 | $12.31 |
| 2007-09-18 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 6,000 | $14.13 |
| 2007-09-18 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 6,000 | $0.00 |
| 2007-09-18 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 6,000 | $6.81 |
| 2007-09-14 | TREBLE, MICHAEL J | Vice President, Head of Ibis | 普通株式 | 売却 | 10,000 | $13.96 |
| 2007-09-14 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 24,000 | $0.00 |
| 2007-09-14 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 14,000 | $14.22 |
| 2007-09-14 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 10,000 | $14.02 |
| 2007-09-14 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 24,000 | $6.81 |
| 2007-09-14 | BENNETT, C FRANK | Vice President | ストックオプション | 売却 | 10,000 | $0.00 |
| 2007-09-14 | BENNETT, C FRANK | Vice President | 普通株式 | 売却 | 10,000 | $13.76 |
| 2007-09-14 | BENNETT, C FRANK | Vice President | 普通株式 | 購入 | 10,000 | $5.15 |
| 2007-09-14 | TREBLE, MICHAEL J | Vice President, Head of Ibis | 普通株式 | 購入 | 10,000 | $5.95 |
| 2007-09-14 | TREBLE, MICHAEL J | Vice President, Head of Ibis | ストックオプション | 売却 | 10,000 | $0.00 |
| 2007-09-11 | PARSHALL, B LYNNE | Director, Executive Vice President | ストックオプション | 売却 | 6,466 | $0.00 |
| 2007-09-11 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 購入 | 6,466 | $5.15 |
| 2007-09-11 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 6,466 | $13.03 |
| 2007-08-21 | BENNETT, C FRANK | Vice President | 普通株式 | 売却 | 10,000 | $12.50 |
| 2007-08-21 | BENNETT, C FRANK | Vice President | ストックオプション | 売却 | 10,000 | $0.00 |
| 2007-08-21 | BENNETT, C FRANK | Vice President | 普通株式 | 購入 | 10,000 | $6.25 |
| 2007-07-12 | TREBLE, MICHAEL J | Vice President, Head of Ibis | ストックオプション | 売却 | 10,000 | $0.00 |
| 2007-07-12 | TREBLE, MICHAEL J | Vice President, Head of Ibis | 普通株式 | 売却 | 10,000 | $11.95 |
| 2007-07-12 | TREBLE, MICHAEL J | Vice President, Head of Ibis | 普通株式 | 購入 | 10,000 | $5.95 |
| 2007-07-10 | TREBLE, MICHAEL J | Vice President, Head of Ibis | ストックオプション | 売却 | 10,000 | $0.00 |
| 2007-07-10 | TREBLE, MICHAEL J | Vice President, Head of Ibis | 普通株式 | 購入 | 10,000 | $5.25 |
| 2007-07-10 | TREBLE, MICHAEL J | Vice President, Head of Ibis | 普通株式 | 売却 | 10,000 | $11.95 |
| 2007-07-09 | BENNETT, C FRANK | Vice President | ストックオプション | 売却 | 4,599 | $0.00 |
| 2007-07-09 | BENNETT, C FRANK | Vice President | 普通株式 | 売却 | 4,599 | $10.57 |
| 2007-07-09 | BENNETT, C FRANK | Vice President | 普通株式 | 購入 | 4,599 | $5.15 |
| 2007-07-09 | BENNETT, C FRANK | Vice President | 普通株式 | 売却 | 1,133 | $11.00 |
| 2007-07-06 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 売却 | 5,200 | $10.12 |
| 2007-07-06 | WEDEL, MARK K | VP & Chief Medical Officer | ストックオプション | 売却 | 3,305 | $0.00 |
| 2007-07-06 | WEDEL, MARK K | VP & Chief Medical Officer | ストックオプション | 売却 | 1,895 | $0.00 |
| 2007-07-06 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 購入 | 3,305 | $5.80 |
| 2007-07-06 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 購入 | 1,895 | $5.25 |
| 2007-07-03 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 835 | $9.85 |
| 2007-07-02 | REED, JOHN C | Director | ストックオプション | 購入 | 12,500 | $0.00 |
| 2007-07-02 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 売却 | 902 | $9.70 |
| 2007-07-02 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 12,500 | $0.00 |
| 2007-07-02 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 12,500 | $0.00 |
| 2007-07-02 | DIMARCHI, RICHARD D | Director | ストックオプション | 購入 | 12,500 | $0.00 |
| 2007-07-02 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 12,500 | $0.00 |
| 2007-07-02 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 12,500 | $0.00 |
| 2007-07-01 | BENNETT, C FRANK | Vice President | 普通株式 | 購入 | 197 | $8.23 |
| 2007-07-01 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 594 | $8.23 |
| 2007-07-01 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 購入 | 902 | $8.23 |
| 2007-07-01 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 購入 | 1,949 | $8.23 |
| 2007-05-09 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 売却 | 2,800 | $0.00 |
| 2007-05-09 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 売却 | 2,800 | $10.36 |
| 2007-05-09 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 購入 | 2,800 | $5.15 |
| 2007-05-02 | WEDEL, MARK K | VP & Chief Medical Officer | ストックオプション | 売却 | 2,000 | $0.00 |
| 2007-05-02 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 売却 | 2,000 | $10.25 |
| 2007-05-02 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 購入 | 2,000 | $5.15 |
| 2007-05-01 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 5,000 | $0.00 |
| 2007-04-25 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 売却 | 13,711 | $10.11 |
| 2007-04-25 | WEDEL, MARK K | VP & Chief Medical Officer | ストックオプション | 売却 | 4,375 | $0.00 |
| 2007-04-25 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 購入 | 4,375 | $3.94 |
| 2007-04-25 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 6,000 | $10.11 |
| 2007-04-25 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 購入 | 5,625 | $5.25 |
| 2007-04-25 | LEVIN, ARTHUR A | Vice President | ストックオプション | 売却 | 6,000 | $0.00 |
| 2007-04-25 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 6,000 | $5.25 |
| 2007-04-25 | WEDEL, MARK K | VP & Chief Medical Officer | ストックオプション | 売却 | 5,625 | $0.00 |
| 2007-04-17 | PARSHALL, B LYNNE | Director, Executive Vice President | ストックオプション | 売却 | 10,000 | $0.00 |
| 2007-04-17 | PARSHALL, B LYNNE | Director, Executive Vice President | ストックオプション | 購入 | 5,000 | $0.00 |
| 2007-02-01 | JONAS, JEFFREY M | Executive Vice President | ストックオプション | 購入 | 130,000 | $0.00 |
| 2007-01-02 | TREBLE, MICHAEL J | Vice President, Head of Ibis | ストックオプション | 購入 | 41,110 | $0.00 |
| 2007-01-02 | WEDEL, MARK K | VP & Chief Medical Officer | ストックオプション | 購入 | 37,535 | $0.00 |
| 2007-01-02 | PARSHALL, B LYNNE | Director, Executive Vice President | ストックオプション | 購入 | 77,454 | $0.00 |
| 2007-01-02 | LEVIN, ARTHUR A | Vice President | ストックオプション | 購入 | 36,145 | $0.00 |
| 2007-01-02 | ECKER, DAVID J | Vice President | ストックオプション | 購入 | 41,706 | $0.00 |
| 2007-01-02 | BENNETT, C FRANK | Vice President | ストックオプション | 購入 | 36,145 | $0.00 |
| 2007-01-02 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 5,958 | $0.00 |
| 2007-01-02 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 178,740 | $0.00 |
| 2007-01-01 | BENNETT, C FRANK | Vice President | 普通株式 | 購入 | 302 | $5.14 |
| 2007-01-01 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 購入 | 1,338 | $5.14 |
| 2007-01-01 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 購入 | 698 | $5.14 |
| 2007-01-01 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 3,181 | $5.14 |
| 2006-12-08 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 11,100 | $6.81 |
| 2006-12-08 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 11,100 | $0.00 |
| 2006-12-08 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 11,100 | $12.04 |
| 2006-12-04 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 5,000 | $11.50 |
| 2006-12-04 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 5,000 | $0.00 |
| 2006-12-04 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 5,000 | $6.81 |
| 2006-11-14 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 3,900 | $6.81 |
| 2006-11-14 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 3,900 | $0.00 |
| 2006-11-14 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 3,900 | $12.11 |
| 2006-11-13 | BENNETT, C FRANK | Vice President | ストックオプション | 売却 | 10,000 | $0.00 |
| 2006-11-13 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 10,000 | $0.00 |
| 2006-11-13 | LEVIN, ARTHUR A | Vice President | ストックオプション | 売却 | 30,000 | $0.00 |
| 2006-11-13 | BENNETT, C FRANK | Vice President | 普通株式 | 購入 | 10,000 | $5.15 |
| 2006-11-13 | PARSHALL, B LYNNE | Director, Executive Vice President | ストックオプション | 売却 | 10,000 | $0.00 |
| 2006-11-13 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 10,000 | $13.36 |
| 2006-11-13 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 10,000 | $13.36 |
| 2006-11-13 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 購入 | 10,000 | $5.15 |
| 2006-11-13 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 10,000 | $6.81 |
| 2006-11-13 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 30,000 | $6.81 |
| 2006-11-13 | BENNETT, C FRANK | Vice President | 普通株式 | 売却 | 10,000 | $13.36 |
| 2006-11-13 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 20,000 | $13.36 |
| 2006-11-13 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 30,000 | $13.36 |
| 2006-11-10 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 6,788 | $10.41 |
| 2006-11-10 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 6,788 | $0.00 |
| 2006-11-10 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 10,000 | $10.41 |
| 2006-11-10 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 6,788 | $5.15 |
| 2006-11-09 | BENNETT, C FRANK | Vice President | 普通株式 | 売却 | 10,000 | $10.13 |
| 2006-11-09 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 20,000 | $0.00 |
| 2006-11-09 | LEVIN, ARTHUR A | Vice President | ストックオプション | 売却 | 20,000 | $0.00 |
| 2006-11-09 | PARSHALL, B LYNNE | Director, Executive Vice President | ストックオプション | 売却 | 10,000 | $0.00 |
| 2006-11-09 | PARSHALL, B LYNNE | Director, Executive Vice President | ストックオプション | 売却 | 5,000 | $0.00 |
| 2006-11-09 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 10,000 | $10.13 |
| 2006-11-09 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 購入 | 5,000 | $5.15 |
| 2006-11-09 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 20,000 | $10.13 |
| 2006-11-09 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 20,000 | $6.81 |
| 2006-11-09 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 20,000 | $10.13 |
| 2006-11-09 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 購入 | 10,000 | $5.15 |
| 2006-11-09 | BENNETT, C FRANK | Vice President | 普通株式 | 購入 | 10,000 | $5.15 |
| 2006-11-09 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 5,000 | $10.13 |
| 2006-11-09 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 20,000 | $10.13 |
| 2006-11-09 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 20,000 | $5.15 |
| 2006-11-09 | BENNETT, C FRANK | Vice President | ストックオプション | 売却 | 10,000 | $0.00 |
| 2006-10-19 | LEVIN, ARTHUR A | Vice President | ストックオプション | 売却 | 9,828 | $0.00 |
| 2006-10-19 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 924 | $9.00 |
| 2006-10-19 | LEVIN, ARTHUR A | Vice President | ストックオプション | 売却 | 2,596 | $0.00 |
| 2006-10-19 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 3,000 | $8.98 |
| 2006-10-19 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 2,596 | $5.15 |
| 2006-10-19 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 2,500 | $9.00 |
| 2006-10-19 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 3,000 | $8.97 |
| 2006-10-19 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 9,828 | $5.80 |
| 2006-10-19 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 3,000 | $8.95 |
| 2006-10-06 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 3,000 | $7.98 |
| 2006-10-06 | LEVIN, ARTHUR A | Vice President | ストックオプション | 売却 | 10,000 | $0.00 |
| 2006-10-06 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 893 | $8.00 |
| 2006-10-06 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 2,000 | $7.99 |
| 2006-10-06 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 507 | $7.96 |
| 2006-10-06 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 2,000 | $7.95 |
| 2006-10-06 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 10,000 | $5.15 |
| 2006-10-06 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 1,600 | $7.96 |
| 2006-09-21 | PARSHALL, B LYNNE | Director, Executive Vice President | ストックオプション | 購入 | 30,000 | $0.00 |
| 2006-09-21 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 50,000 | $0.00 |
| 2006-08-15 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,000 | $6.26 |
| 2006-08-01 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,000 | $6.00 |
| 2006-07-18 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,000 | $5.91 |
| 2006-07-03 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 12,500 | $0.00 |
| 2006-07-03 | REED, JOHN C | Director | ストックオプション | 購入 | 12,500 | $0.00 |
| 2006-07-03 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,000 | $6.02 |
| 2006-07-03 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 12,500 | $0.00 |
| 2006-07-03 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 12,500 | $0.00 |
| 2006-07-03 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 12,500 | $0.00 |
| 2006-07-03 | DIMARCHI, RICHARD D | Director | ストックオプション | 購入 | 12,500 | $0.00 |
| 2006-07-01 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 3,184 | $4.45 |
| 2006-07-01 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 購入 | 1,162 | $4.45 |
| 2006-07-01 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 購入 | 2,406 | $4.45 |
| 2006-07-01 | BENNETT, C FRANK | Vice President | 普通株式 | 購入 | 492 | $4.45 |
| 2006-06-15 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,000 | $6.40 |
| 2006-05-05 | BENNETT, C FRANK | Vice President | 普通株式 | 売却 | 1,500 | $8.58 |
| 2006-05-05 | BENNETT, C FRANK | Vice President | 普通株式 | 売却 | 2,000 | $8.59 |
| 2006-05-05 | BENNETT, C FRANK | Vice President | 普通株式 | 売却 | 1,000 | $8.52 |
| 2006-05-05 | BENNETT, C FRANK | Vice President | 普通株式 | 売却 | 2,000 | $8.57 |
| 2006-05-05 | BENNETT, C FRANK | Vice President | 普通株式 | 売却 | 1,000 | $8.50 |
| 2006-05-05 | BENNETT, C FRANK | Vice President | 普通株式 | 購入 | 8,500 | $5.80 |
| 2006-05-05 | BENNETT, C FRANK | Vice President | 普通株式 | 売却 | 1,000 | $8.53 |
| 2006-05-05 | BENNETT, C FRANK | Vice President | ストックオプション | 売却 | 8,500 | $0.00 |
| 2006-03-21 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 4,901 | $9.01 |
| 2006-03-21 | LEVIN, ARTHUR A | Vice President | ストックオプション | 売却 | 500 | $0.00 |
| 2006-03-21 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 3,120 | $9.06 |
| 2006-03-21 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 191 | $9.01 |
| 2006-03-21 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 482 | $9.02 |
| 2006-03-21 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 12,756 | $5.15 |
| 2006-03-21 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 600 | $9.07 |
| 2006-03-21 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 21 | $9.04 |
| 2006-03-21 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 12,756 | $0.00 |
| 2006-03-21 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 251 | $9.05 |
| 2006-03-21 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 1,991 | $9.00 |
| 2006-03-21 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 84 | $9.00 |
| 2006-03-21 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 55 | $9.03 |
| 2006-03-21 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 9 | $9.05 |
| 2006-03-21 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 99 | $9.06 |
| 2006-03-21 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 500 | $6.84 |
| 2006-03-21 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 1,411 | $9.03 |
| 2006-03-21 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 18 | $9.02 |
| 2006-03-21 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 23 | $9.07 |
| 2006-03-20 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 14,032 | $0.00 |
| 2006-03-20 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 2,000 | $9.12 |
| 2006-03-20 | LEVIN, ARTHUR A | Vice President | ストックオプション | 売却 | 9,500 | $0.00 |
| 2006-03-20 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 14,032 | $5.15 |
| 2006-03-20 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 5,000 | $9.10 |
| 2006-03-20 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 32 | $8.52 |
| 2006-03-20 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 4,000 | $9.00 |
| 2006-03-20 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 2,000 | $8.92 |
| 2006-03-20 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 1,000 | $9.10 |
| 2006-03-20 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 9,500 | $6.84 |
| 2006-03-20 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 2,000 | $9.12 |
| 2006-03-20 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 1,500 | $9.16 |
| 2006-03-20 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 2,000 | $9.00 |
| 2006-03-20 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 2,000 | $8.98 |
| 2006-03-20 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 2,000 | $8.96 |
| 2006-03-08 | BROWN, RICHARD K | Vice President | 普通株式 | 購入 | 2,770 | $6.84 |
| 2006-03-08 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 770 | $8.01 |
| 2006-03-08 | BROWN, RICHARD K | Vice President | ストックオプション | 売却 | 2,770 | $0.00 |
| 2006-03-08 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 500 | $8.15 |
| 2006-03-08 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 500 | $8.07 |
| 2006-03-08 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 500 | $8.09 |
| 2006-03-08 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 500 | $8.04 |
| 2006-03-07 | BROWN, RICHARD K | Vice President | 普通株式 | 購入 | 2,000 | $6.84 |
| 2006-03-07 | BROWN, RICHARD K | Vice President | ストックオプション | 売却 | 2,000 | $0.00 |
| 2006-03-07 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 2,000 | $7.97 |
| 2006-03-03 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,000 | $8.20 |
| 2006-03-03 | BROWN, RICHARD K | Vice President | 普通株式 | 購入 | 1,008 | $6.84 |
| 2006-03-03 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 8 | $8.26 |
| 2006-03-03 | BROWN, RICHARD K | Vice President | ストックオプション | 売却 | 1,008 | $0.00 |
| 2006-03-02 | BROWN, RICHARD K | Vice President | 普通株式 | 購入 | 3,600 | $6.84 |
| 2006-03-02 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,600 | $8.22 |
| 2006-03-02 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,000 | $8.19 |
| 2006-03-02 | BROWN, RICHARD K | Vice President | ストックオプション | 売却 | 3,600 | $0.00 |
| 2006-03-02 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,000 | $8.17 |
| 2006-03-01 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 660 | $8.08 |
| 2006-03-01 | BROWN, RICHARD K | Vice President | ストックオプション | 売却 | 2,660 | $0.00 |
| 2006-03-01 | BROWN, RICHARD K | Vice President | ストックオプション | 売却 | 3,340 | $0.00 |
| 2006-03-01 | BROWN, RICHARD K | Vice President | 普通株式 | 購入 | 2,660 | $6.81 |
| 2006-03-01 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,000 | $8.05 |
| 2006-03-01 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,000 | $8.06 |
| 2006-03-01 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,000 | $8.09 |
| 2006-03-01 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,000 | $8.11 |
| 2006-03-01 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,000 | $8.13 |
| 2006-03-01 | BROWN, RICHARD K | Vice President | 普通株式 | 購入 | 3,340 | $6.84 |
| 2006-03-01 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 340 | $8.08 |
| 2006-02-28 | BROWN, RICHARD K | Vice President | ストックオプション | 売却 | 2,000 | $0.00 |
| 2006-02-28 | BROWN, RICHARD K | Vice President | 普通株式 | 購入 | 2,000 | $6.81 |
| 2006-02-28 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 2,000 | $8.01 |
| 2006-02-27 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,000 | $8.17 |
| 2006-02-27 | BROWN, RICHARD K | Vice President | ストックオプション | 売却 | 3,715 | $0.00 |
| 2006-02-27 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 500 | $8.08 |
| 2006-02-27 | BROWN, RICHARD K | Vice President | 普通株式 | 購入 | 3,715 | $6.81 |
| 2006-02-27 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 3,715 | $0.00 |
| 2006-02-27 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,015 | $8.09 |
| 2006-02-27 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 500 | $8.07 |
| 2006-02-27 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 700 | $8.10 |
| 2006-02-24 | BROWN, RICHARD K | Vice President | 普通株式 | 購入 | 1,000 | $6.81 |
| 2006-02-24 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,000 | $8.02 |
| 2006-02-24 | BROWN, RICHARD K | Vice President | ストックオプション | 売却 | 1,000 | $0.00 |
| 2006-02-22 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,185 | $7.88 |
| 2006-02-22 | BROWN, RICHARD K | Vice President | 普通株式 | 購入 | 1,185 | $5.80 |
| 2006-02-22 | BROWN, RICHARD K | Vice President | ストックオプション | 売却 | 1,185 | $0.00 |
| 2006-02-21 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 500 | $8.02 |
| 2006-02-21 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,300 | $8.03 |
| 2006-02-21 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 200 | $8.04 |
| 2006-02-21 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 100 | $8.33 |
| 2006-02-21 | BROWN, RICHARD K | Vice President | 普通株式 | 購入 | 3,100 | $5.80 |
| 2006-02-21 | BROWN, RICHARD K | Vice President | ストックオプション | 売却 | 3,100 | $0.00 |
| 2006-02-21 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,000 | $7.88 |
| 2006-02-17 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 2,000 | $8.21 |
| 2006-02-17 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 26,789 | $8.02 |
| 2006-02-17 | BROWN, RICHARD K | Vice President | 普通株式 | 購入 | 9,000 | $5.15 |
| 2006-02-17 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 7,770 | $5.15 |
| 2006-02-17 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 26,789 | $0.00 |
| 2006-02-17 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 26,789 | $5.15 |
| 2006-02-17 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 3,000 | $0.00 |
| 2006-02-17 | BROWN, RICHARD K | Vice President | ストックオプション | 売却 | 9,000 | $0.00 |
| 2006-02-17 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 2,000 | $8.07 |
| 2006-02-17 | BROWN, RICHARD K | Vice President | 普通株式 | 購入 | 3,000 | $5.80 |
| 2006-02-17 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 1,000 | $8.01 |
| 2006-02-17 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 2,000 | $8.05 |
| 2006-02-17 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 2,000 | $8.11 |
| 2006-02-17 | BROWN, RICHARD K | Vice President | 普通株式 | 売却 | 2,000 | $8.28 |
| 2006-02-17 | LEVIN, ARTHUR A | Vice President | ストックオプション | 売却 | 7,770 | $0.00 |
| 2006-02-17 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 7,770 | $8.03 |
| 2006-02-16 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 3,000 | $7.95 |
| 2006-02-16 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 3,000 | $5.15 |
| 2006-02-16 | LEVIN, ARTHUR A | Vice President | ストックオプション | 売却 | 3,000 | $0.00 |
| 2006-02-09 | BENNETT, C FRANK | Vice President | 普通株式 | 売却 | 1,500 | $6.50 |
| 2006-02-01 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,000 | $5.48 |
| 2006-01-17 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,000 | $5.46 |
| 2006-01-03 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,000 | $5.16 |
| 2006-01-03 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 128,924 | $0.00 |
| 2006-01-03 | PARSHALL, B LYNNE | Director, Executive Vice President | ストックオプション | 購入 | 49,506 | $0.00 |
| 2006-01-03 | TREBLE, MICHAEL J | Vice President, Head of Ibis | ストックオプション | 購入 | 40,842 | $0.00 |
| 2006-01-03 | WEDEL, MARK K | VP & Chief Medical Officer | ストックオプション | 購入 | 25,784 | $0.00 |
| 2006-01-03 | BROWN, RICHARD K | Vice President | ストックオプション | 購入 | 31,560 | $0.00 |
| 2006-01-03 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 6,000 | $0.00 |
| 2006-01-03 | ECKER, DAVID J | Vice President | ストックオプション | 購入 | 36,098 | $0.00 |
| 2006-01-03 | LEVIN, ARTHUR A | Vice President | ストックオプション | 購入 | 29,703 | $0.00 |
| 2006-01-03 | BENNETT, C FRANK | Vice President | ストックオプション | 購入 | 30,322 | $0.00 |
| 2006-01-01 | BENNETT, C FRANK | Vice President | 普通株式 | 購入 | 190 | $3.36 |
| 2006-01-01 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 購入 | 835 | $3.36 |
| 2006-01-01 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 購入 | 394 | $3.36 |
| 2006-01-01 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 1,889 | $3.36 |
| 2005-12-15 | KLEIN, JOSEPH III | Director | 普通株式 | 購入 | 2,000 | $5.18 |
| 2005-12-13 | KLEIN, JOSEPH III | Director | ストックオプション | 購入 | 20,000 | $0.00 |
| 2005-09-19 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 150 | $5.30 |
| 2005-09-19 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 500 | $5.25 |
| 2005-09-19 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 100 | $5.35 |
| 2005-09-19 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 347 | $5.36 |
| 2005-09-19 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 53 | $5.34 |
| 2005-09-16 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 300 | $5.31 |
| 2005-09-15 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 200 | $5.25 |
| 2005-09-15 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 200 | $5.30 |
| 2005-09-15 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 208 | $5.15 |
| 2005-09-14 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 450 | $5.29 |
| 2005-09-13 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 500 | $5.40 |
| 2005-09-12 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 300 | $5.54 |
| 2005-09-12 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 200 | $5.50 |
| 2005-09-12 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 200 | $5.49 |
| 2005-09-09 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 400 | $5.50 |
| 2005-09-09 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 200 | $5.54 |
| 2005-09-09 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 400 | $5.45 |
| 2005-09-08 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 600 | $5.35 |
| 2005-09-08 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 100 | $5.40 |
| 2005-09-08 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 100 | $5.49 |
| 2005-09-08 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 100 | $5.30 |
| 2005-09-08 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 100 | $5.45 |
| 2005-07-05 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 2,702 | $3.85 |
| 2005-07-01 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 10,000 | $0.00 |
| 2005-07-01 | DIMARCHI, RICHARD D | Director | ストックオプション | 購入 | 10,000 | $0.00 |
| 2005-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 10,000 | $0.00 |
| 2005-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 10,000 | $0.00 |
| 2005-07-01 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 購入 | 856 | $3.36 |
| 2005-07-01 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 3,477 | $3.36 |
| 2005-07-01 | BENNETT, C FRANK | Vice President | 普通株式 | 購入 | 591 | $3.36 |
| 2005-07-01 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 購入 | 2,702 | $3.36 |
| 2005-07-01 | REED, JOHN C | Director | ストックオプション | 購入 | 10,000 | $0.00 |
| 2005-07-01 | GABRIELI, CHRISTOPHER | Director | ストックオプション | 購入 | 10,000 | $0.00 |
| 2005-06-24 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 2,446 | $4.01 |
| 2005-06-24 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 2,000 | $4.00 |
| 2005-05-25 | WEDEL, MARK K | VP & Chief Medical Officer | 普通株式 | 購入 | 10,000 | $0.00 |
| 2005-01-03 | BROWN, RICHARD K | Vice President | ストックオプション | 購入 | 26,900 | $0.00 |
| 2005-01-03 | BENNETT, C FRANK | Vice President | ストックオプション | 購入 | 25,555 | $0.00 |
| 2005-01-03 | LOWENSTAM, PATRICIA | Vice President | ストックオプション | 購入 | 18,158 | $0.00 |
| 2005-01-03 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 85,000 | $0.00 |
| 2005-01-03 | PARSHALL, B LYNNE | Director, Executive Vice President | ストックオプション | 購入 | 30,263 | $0.00 |
| 2005-01-03 | ECKER, DAVID J | Vice President | ストックオプション | 購入 | 28,918 | $0.00 |
| 2005-01-03 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 5,380 | $0.00 |
| 2005-01-03 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 購入 | 75,720 | $0.00 |
| 2005-01-03 | MCNEIL, JOHN A | Vice President | ストックオプション | 購入 | 18,158 | $0.00 |
| 2005-01-03 | LEVIN, ARTHUR A | Vice President | ストックオプション | 購入 | 22,462 | $0.00 |
| 2005-01-01 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 購入 | 924 | $4.67 |
| 2005-01-01 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 182 | $4.67 |
| 2005-01-01 | BENNETT, C FRANK | Vice President | 普通株式 | 購入 | 200 | $4.67 |
| 2005-01-01 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 2,008 | $4.67 |
| 2004-12-22 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 1,000 | $6.20 |
| 2004-12-22 | LEVIN, ARTHUR A | Vice President | ストックオプション | 売却 | 1,000 | $0.00 |
| 2004-12-22 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 1,000 | $5.88 |
| 2004-12-14 | DIMARCHI, RICHARD D | Director | ストックオプション | 購入 | 20,000 | $0.00 |
| 2004-12-13 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 1,747 | $0.00 |
| 2004-12-13 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 1,747 | $4.00 |
| 2004-12-13 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 1,747 | $6.20 |
| 2004-12-10 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 1,600 | $6.15 |
| 2004-12-10 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 2,400 | $0.00 |
| 2004-12-10 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 2,400 | $4.00 |
| 2004-12-10 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 2,400 | $6.15 |
| 2004-12-10 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 1,600 | $5.88 |
| 2004-12-10 | LEVIN, ARTHUR A | Vice President | ストックオプション | 売却 | 5,500 | $0.00 |
| 2004-12-10 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 2,900 | $6.20 |
| 2004-12-10 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 2,900 | $5.88 |
| 2004-12-10 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 1,000 | $6.19 |
| 2004-12-10 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 1,000 | $5.88 |
| 2004-12-09 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 1,000 | $6.07 |
| 2004-12-09 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 1,000 | $6.06 |
| 2004-12-09 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 2,000 | $6.05 |
| 2004-12-09 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 696 | $5.95 |
| 2004-12-09 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 購入 | 696 | $4.00 |
| 2004-12-09 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 1,000 | $5.90 |
| 2004-12-09 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 3,000 | $5.88 |
| 2004-12-09 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 3,000 | $6.15 |
| 2004-12-09 | LEVIN, ARTHUR A | Vice President | ストックオプション | 売却 | 3,000 | $0.00 |
| 2004-12-09 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 1,000 | $6.09 |
| 2004-12-09 | LOWENSTAM, PATRICIA | Vice President | ストックオプション | 売却 | 8,696 | $0.00 |
| 2004-12-09 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 購入 | 2,000 | $4.00 |
| 2004-12-09 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 2,000 | $6.10 |
| 2004-12-09 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 購入 | 1,000 | $4.00 |
| 2004-12-08 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 1,000 | $5.88 |
| 2004-12-08 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 1,000 | $5.90 |
| 2004-12-08 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 1,000 | $5.80 |
| 2004-12-08 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 5,000 | $0.00 |
| 2004-12-08 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 購入 | 696 | $3.75 |
| 2004-12-08 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 696 | $5.86 |
| 2004-12-08 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 購入 | 304 | $4.00 |
| 2004-12-08 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 304 | $5.86 |
| 2004-12-08 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 2,000 | $4.00 |
| 2004-12-08 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 2,000 | $5.85 |
| 2004-12-08 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 1,000 | $4.00 |
| 2004-12-08 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 購入 | 1,000 | $3.75 |
| 2004-12-08 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 1,000 | $5.85 |
| 2004-12-08 | LOWENSTAM, PATRICIA | Vice President | ストックオプション | 売却 | 304 | $0.00 |
| 2004-12-08 | LOWENSTAM, PATRICIA | Vice President | ストックオプション | 売却 | 1,696 | $0.00 |
| 2004-12-07 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 4,000 | $0.00 |
| 2004-12-07 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 購入 | 1,000 | $4.00 |
| 2004-12-07 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 1,000 | $5.90 |
| 2004-12-07 | LOWENSTAM, PATRICIA | Vice President | ストックオプション | 売却 | 1,000 | $0.00 |
| 2004-12-07 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 4,000 | $5.90 |
| 2004-12-07 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 4,000 | $4.00 |
| 2004-12-07 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 購入 | 1,000 | $3.75 |
| 2004-12-07 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 1,000 | $5.85 |
| 2004-12-06 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 5,000 | $5.79 |
| 2004-12-06 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 2,000 | $4.00 |
| 2004-12-06 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 購入 | 5,000 | $3.75 |
| 2004-12-06 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 2,000 | $0.00 |
| 2004-12-06 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 2,000 | $5.79 |
| 2004-12-06 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 4,000 | $0.00 |
| 2004-12-06 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 4,000 | $5.73 |
| 2004-12-06 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 4,000 | $4.00 |
| 2004-12-06 | LOWENSTAM, PATRICIA | Vice President | ストックオプション | 売却 | 5,000 | $0.00 |
| 2004-12-03 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 7,000 | $0.00 |
| 2004-12-03 | LOWENSTAM, PATRICIA | Vice President | ストックオプション | 売却 | 5,000 | $0.00 |
| 2004-12-03 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 5,000 | $6.32 |
| 2004-12-03 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 購入 | 5,000 | $3.75 |
| 2004-12-03 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 7,000 | $4.00 |
| 2004-12-03 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 4,817 | $5.88 |
| 2004-12-03 | LEVIN, ARTHUR A | Vice President | 普通株式 | 売却 | 4,817 | $6.32 |
| 2004-12-03 | LEVIN, ARTHUR A | Vice President | ストックオプション | 売却 | 4,817 | $0.00 |
| 2004-12-03 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 7,000 | $6.32 |
| 2004-12-02 | LOWENSTAM, PATRICIA | Vice President | ストックオプション | 売却 | 12,304 | $0.00 |
| 2004-12-02 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 7,051 | $0.00 |
| 2004-12-02 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 12,304 | $5.45 |
| 2004-12-02 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 12,304 | $4.00 |
| 2004-12-02 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 5,253 | $0.00 |
| 2004-12-02 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 12,304 | $5.45 |
| 2004-12-02 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 購入 | 12,304 | $3.75 |
| 2004-12-01 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 購入 | 5,000 | $3.75 |
| 2004-12-01 | LOWENSTAM, PATRICIA | Vice President | ストックオプション | 売却 | 5,000 | $0.00 |
| 2004-12-01 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 5,000 | $4.90 |
| 2004-12-01 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 5,000 | $0.00 |
| 2004-12-01 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 5,000 | $4.90 |
| 2004-12-01 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 5,000 | $4.00 |
| 2004-11-30 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 4,000 | $4.71 |
| 2004-11-30 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 4,000 | $4.00 |
| 2004-11-30 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 4,000 | $0.00 |
| 2004-11-29 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 1,549 | $4.62 |
| 2004-11-29 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 1,549 | $4.00 |
| 2004-11-29 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 1,549 | $0.00 |
| 2004-11-17 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 4,900 | $0.00 |
| 2004-11-17 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 4,900 | $4.60 |
| 2004-11-17 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 4,900 | $4.00 |
| 2004-11-16 | CROOKE, STANLEY T | Director, Chairman, President, CEO | ストックオプション | 売却 | 2,500 | $0.00 |
| 2004-11-16 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 2,500 | $4.52 |
| 2004-11-16 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 購入 | 2,500 | $4.00 |
| 2004-09-30 | PARSHALL, B LYNNE | Director, Executive Vice President | ストックオプション | 売却 | 30,000 | $0.00 |
| 2004-09-30 | PARSHALL, B LYNNE | Director, Executive Vice President | ストックオプション | 購入 | 15,000 | $0.00 |
| 2004-07-01 | BENNETT, C FRANK | Vice President | 普通株式 | 購入 | 295 | $4.86 |
| 2004-07-01 | STEIN, ARON | Vice President | 普通株式 | 購入 | 600 | $4.86 |
| 2004-07-01 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 購入 | 1,303 | $4.86 |
| 2004-07-01 | LEVIN, ARTHUR A | Vice President | 普通株式 | 購入 | 272 | $4.86 |
| 2004-07-01 | REED, JOHN C | Director | ストックオプション | 購入 | 10,000 | $0.00 |
| 2004-07-01 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 2,920 | $4.86 |
| 2004-07-01 | SKALETSKY, MARK B | Director | ストックオプション | 購入 | 10,000 | $0.00 |
| 2004-07-01 | GABRIELI, CHRISTOPHER | Director | ストックオプション | 購入 | 10,000 | $0.00 |
| 2004-07-01 | BERTHELSEN, SPENCER R | Director | ストックオプション | 購入 | 10,000 | $0.00 |
| 2004-07-01 | MUTO, FREDERICK T | Director | ストックオプション | 購入 | 10,000 | $0.00 |
| 2004-07-01 | WENDER, JOSEPH H | Director | ストックオプション | 購入 | 10,000 | $0.00 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 購入 | 20,000 | $6.38 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 500 | $6.70 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 1,500 | $6.63 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 1,800 | $6.62 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 1,700 | $6.61 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | ストックオプション | 売却 | 20,000 | $0.00 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 1,000 | $6.65 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 1,100 | $6.77 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 1,000 | $6.71 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 2,000 | $6.72 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 1,000 | $6.73 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 200 | $6.74 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 2,700 | $6.75 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 2,500 | $6.78 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 1,000 | $6.79 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 1,000 | $6.80 |
| 2004-05-14 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 1,000 | $6.82 |
| 2004-04-27 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 2,400 | $9.02 |
| 2004-04-27 | DE, HAAN HANS A | VP, Drug Development | 普通株式 | 売却 | 5,600 | $9.80 |
| 2004-03-10 | LUNDSTEDT, KAREN S | Vice President | 普通株式 | 売却 | 1,000 | $9.31 |
| 2004-03-10 | LUNDSTEDT, KAREN S | Vice President | 普通株式 | 購入 | 1,000 | $6.81 |
| 2004-03-10 | LUNDSTEDT, KAREN S | Vice President | ストックオプション | 売却 | 1,000 | $0.00 |
| 2004-03-09 | COLE, DOUGLAS L | Vice President | ストックオプション | 売却 | 2,000 | $0.00 |
| 2004-03-09 | COLE, DOUGLAS L | Vice President | 普通株式 | 購入 | 2,000 | $4.00 |
| 2004-03-09 | LUNDSTEDT, KAREN S | Vice President | ストックオプション | 売却 | 5,000 | $0.00 |
| 2004-03-09 | LUNDSTEDT, KAREN S | Vice President | 普通株式 | 売却 | 5,000 | $9.21 |
| 2004-03-09 | LUNDSTEDT, KAREN S | Vice President | 普通株式 | 購入 | 5,000 | $6.81 |
| 2004-03-09 | COLE, DOUGLAS L | Vice President | 普通株式 | 売却 | 2,000 | $9.21 |
| 2004-03-08 | COLE, DOUGLAS L | Vice President | 普通株式 | 購入 | 20,000 | $3.75 |
| 2004-03-08 | COLE, DOUGLAS L | Vice President | ストックオプション | 売却 | 20,000 | $0.00 |
| 2004-03-08 | LUNDSTEDT, KAREN S | Vice President | 普通株式 | 売却 | 5,000 | $9.32 |
| 2004-03-08 | LUNDSTEDT, KAREN S | Vice President | 普通株式 | 購入 | 5,000 | $6.81 |
| 2004-03-08 | COLE, DOUGLAS L | Vice President | ストックオプション | 売却 | 10,000 | $0.00 |
| 2004-03-08 | COLE, DOUGLAS L | Vice President | 普通株式 | 売却 | 30,000 | $9.32 |
| 2004-03-08 | LUNDSTEDT, KAREN S | Vice President | ストックオプション | 売却 | 5,000 | $0.00 |
| 2004-03-08 | COLE, DOUGLAS L | Vice President | 普通株式 | 購入 | 10,000 | $4.00 |
| 2004-03-05 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 2,222 | $0.00 |
| 2004-03-05 | COLE, DOUGLAS L | Vice President | 普通株式 | 売却 | 30,000 | $9.10 |
| 2004-03-05 | COLE, DOUGLAS L | Vice President | 普通株式 | 購入 | 30,000 | $3.75 |
| 2004-03-05 | LUNDSTEDT, KAREN S | Vice President | ストックオプション | 売却 | 5,000 | $0.00 |
| 2004-03-05 | LUNDSTEDT, KAREN S | Vice President | 普通株式 | 売却 | 5,000 | $9.10 |
| 2004-03-05 | LUNDSTEDT, KAREN S | Vice President | 普通株式 | 購入 | 5,000 | $6.81 |
| 2004-03-05 | COLE, DOUGLAS L | Vice President | ストックオプション | 売却 | 30,000 | $0.00 |
| 2004-03-05 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 4,444 | $0.00 |
| 2004-02-11 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 2,582 | $9.06 |
| 2004-02-11 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 2,582 | $4.00 |
| 2004-02-11 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 2,582 | $0.00 |
| 2004-02-06 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 1,000 | $8.70 |
| 2004-02-06 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 6,368 | $4.00 |
| 2004-02-06 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 6,368 | $8.70 |
| 2004-02-06 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 6,368 | $0.00 |
| 2004-02-03 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 700 | $0.00 |
| 2004-02-03 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 700 | $4.00 |
| 2004-02-03 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 700 | $9.03 |
| 2004-02-02 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 2,500 | $4.00 |
| 2004-02-02 | ECKER, DAVID J | Vice President | ストックオプション | 売却 | 2,500 | $0.00 |
| 2004-02-02 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 2,500 | $9.10 |
| 2004-01-29 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 5,000 | $9.16 |
| 2004-01-28 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 5,000 | $8.91 |
| 2004-01-27 | PARSHALL, B LYNNE | Director, Executive Vice President | 普通株式 | 売却 | 750 | $0.00 |
| 2004-01-26 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 8,000 | $8.62 |
| 2004-01-23 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 4,000 | $8.28 |
| 2004-01-22 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 500 | $8.19 |
| 2004-01-21 | BENNETT, C FRANK | Vice President | 普通株式 | 売却 | 1,000 | $8.12 |
| 2004-01-21 | LOWENSTAM, PATRICIA | Vice President | ストックオプション | 売却 | 20,000 | $0.00 |
| 2004-01-21 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 7,000 | $8.02 |
| 2004-01-21 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 購入 | 20,000 | $3.75 |
| 2004-01-21 | LOWENSTAM, PATRICIA | Vice President | 普通株式 | 売却 | 20,000 | $8.12 |
| 2004-01-20 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 8,000 | $7.50 |
| 2004-01-16 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 2,000 | $7.50 |
| 2004-01-15 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 5,500 | $7.54 |
| 2004-01-14 | WENDER, JOSEPH H | Director | ストックオプション | 売却 | 20,000 | $0.00 |
| 2004-01-14 | CROOKE, STANLEY T | Director, Chairman, President, CEO | 普通株式 | 売却 | 5,000 | $7.51 |
| 2004-01-14 | WENDER, JOSEPH H | Director | 普通株式 | 購入 | 20,000 | $6.50 |
| 2004-01-14 | WENDER, JOSEPH H | Director | 普通株式 | 売却 | 20,000 | $7.46 |
| 2004-01-02 | MCNEIL, JOHN A | VP, Infomatics | ストックオプション | 購入 | 25,000 | $6.81 |
| 2004-01-02 | CROOKE, STANLEY T | Director, Chairman, CEO, President | ストックオプション | 購入 | 4,725 | $6.81 |
| 2004-01-02 | LUNDSTEDT, KAREN S | VP, Corporate Communications | ストックオプション | 購入 | 20,160 | $6.81 |
| 2004-01-02 | LOWENSTAM, PATRICIA | VP, Human Resources, Opers | ストックオプション | 購入 | 20,160 | $6.81 |
| 2004-01-02 | CROOKE, STANLEY T | Director, Chairman, CEO, President | ストックオプション | 購入 | 80,000 | $6.81 |
| 2004-01-02 | LEVIN, ARTHUR A | VP, Development | ストックオプション | 購入 | 26,880 | $6.81 |
| 2004-01-02 | BROWN, RICHARD K | VP, Business Development | ストックオプション | 購入 | 18,000 | $6.81 |
| 2004-01-02 | ECKER, DAVID J | President, Ibis Therapeutics | ストックオプション | 購入 | 32,640 | $6.81 |
| 2004-01-02 | BENNETT, C FRANK | Vice President | ストックオプション | 購入 | 28,800 | $6.81 |
| 2004-01-02 | HOLMLUD, JON T | VP, Development | ストックオプション | 購入 | 20,160 | $6.81 |
| 2004-01-02 | STEIN, ARON | VP-Regulatory Affairs&Quality | ストックオプション | 購入 | 24,000 | $6.81 |
| 2004-01-02 | COLE, DOUGLAS L | VP, Technical Development | ストックオプション | 購入 | 7,000 | $6.81 |
| 2004-01-02 | PARSHALL, B LYNNE | Director, Executive VP, CFO, Secretary | ストックオプション | 購入 | 38,400 | $6.81 |
| 2004-01-01 | LUNDSTEDT, KAREN S | VP, Corporate Communications | 普通株式 | 購入 | 1,942 | $4.46 |
| 2004-01-01 | HOLMLUD, JON T | VP, Development | 普通株式 | 購入 | 934 | $4.46 |
| 2004-01-01 | STEIN, ARON | VP-Regulatory Affairs&Quality | 普通株式 | 購入 | 936 | $4.46 |
| 2004-01-01 | PARSHALL, B LYNNE | Director, Executive VP, CFO, Secretary | 普通株式 | 購入 | 2,219 | $4.46 |
| 2004-01-01 | LEVIN, ARTHUR A | VP, Development | 普通株式 | 購入 | 442 | $4.46 |
| 2004-01-01 | BENNETT, C FRANK | Vice President | 普通株式 | 購入 | 481 | $4.46 |
| 2004-01-01 | COLE, DOUGLAS L | VP, Technical Development | 普通株式 | 購入 | 398 | $4.46 |
| 2003-09-09 | ECKER, DAVID J | Vice President | 普通株式 | 売却 | 5,714 | $ |
| 2003-09-09 | ECKER, DAVID J | Vice President | 普通株式 | 購入 | 2,857 | $ |
| 2003-08-22 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 678 | $5.86 |
| 2003-08-20 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 11,000 | $5.89 |
| 2003-08-19 | GABRIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 10,000 | $5.82 |
| 2003-07-28 | GARIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 35,000 | $5.05 |
| 2003-07-25 | GARIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 16,000 | $5.01 |
| 2003-07-24 | GARIELI, CHRISTOPHER | Director | 普通株式 | 売却 | 8,401 | $5.16 |
| 2003-07-01 | HOLMLUND, JON T | Vice President | 普通株式 | 購入 | 983 | $4.39 |
売上・収益性
売上高（直近12ヶ月）
$94,371万ドル
一株あたり売上高（直近12ヶ月）
$5.90
売上総利益（直近12ヶ月）
$1,218万ドル
営業利益（EBITDA：減価償却前）
$-36,924万ドル
利益率
-40.4%
営業利益率（直近12ヶ月）
-105.5%
配当・収入
配当金額（1株あたり）
$None
配当利回り
0%
支払日
None
権利落ち日
None
バリュエーション指標
株価収益率（PER）
None倍
実績PER
-倍
予想PER
90.91倍
株価収益成長率（PEG）
25.7
株価売上高倍率（直近12ヶ月）
13.16倍
株価純資産倍率 (PBR)
25.39倍
1株当たり純資産（BPS）
$3.00
企業価値倍率（EV）
EV/売上高倍率
12.51倍
EV/EBITDA倍率
135.77倍
投資リターン
総資産利益率（直近12ヶ月）
-7.31%
自己資本利益率（直近12ヶ月）
-70.8%
リターン分析
| 日数 | リターンレンジ | リターン中央値 | 累積リターン | 分散（バリアンス） | 標準偏差 | 最大下落率 | 最大下落期間 | SPYとの相関係数 | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 15日間 | -1.6486% | 2.4149% | -0.1197% | 2.3039% | 0.00014939306343396053 | 0.012222645516988559 | -1.9364% | 4日 | -0.08102590836571041 | |
| 30日間 | -2.8152% | 4.3341% | -0.2872% | 4.0365% | 0.00030283162437361665 | 0.01740205804994388 | -3.6771% | 8日 | -0.06004255034350231 | |
| 90日間 | -5.3996% | 4.3341% | 0.0296% | -2.5256% | 0.0003899819268630663 | 0.019747960068398615 | -6.8093% | 2日 | -0.05501650999331678 |
損益計算書
会計期末日
2025-12-31
報告通貨
USD
売上高・粗利益
売上原価
営業経費
営業利益・税引前指標
売上高
$944,000,000
粗利益
$928,000,000
売上コスト
$16,000,000
商品・サービス原価
$16,000,000
販売管理費
$393,900,000
研究開発
$916,000,000
運営コスト
$1,310,000,000
減価償却
$None
減価償却・償却費
$20,255,000
営業利益
-$382,000,000
営業利益EBIT
-$307,000,000
償却前営業利益EBITA
-$286,745,000
税引前利益
-$380,000,000
利息・投資・その他営業外項目
税金関連
当期純・包括利益
純投資収益
$None
純金利収入
-$90,082,000
利息収入
$None
金利コスト
$73,000,000
利息・債務コスト
$None
非利息収益
$None
営業外収益（その他）
$None
法人税等
$1,000,000
継続事業純利益
-$381,387,000
純利益
-$381,000,000
税引後包括利益
$None
貸借対照表
会計期末日
2025-12-31
報告通貨
USD
総資産
$3,523,836,000
現金及び現金同等物
$372,260,000
現金及び短期投資
$372,260,000
短期投資
$2,305,176,000
在庫資産
$10,048,000
流動売掛金（純額）
$66,000,000
その他流動資産
$247,000,000
流動資産合計
$2,990,000,000
有形固定資産
$None
減価償却累計額（PPE）
$None
無形資産
$None
無形資産（のれん除く）
$None
のれん（無形資産）
$None
投資
$None
長期投資
$None
その他固定資産
$None
固定資産合計
$533,200,999
総負債
$3,034,747,000
買掛金（短期）
$28,082,000
前受金
$None
流動債務
$None
短期借入金
$453,146,000
固定長期負債
$454,686,000
その他流動負債
$226,578,000
流動負債合計
$781,567,000
リース債務
$262,383,000
長期債務
$1,347,443,000
長期債務（流動外）
$None
短期・長期借入金合計
$2,614,325,000
その他固定負債
$551,353,000
固定負債合計
$2,253,180,000
純資産
$489,089,000
自己株式（金庫株）
$None
利益剰余金
-$2,631,195,000
普通株式
$163,000
発行済株式数（普通株）
$160,000,000
キャッシュフロー計算書
会計期末日
2025-12-31
報告通貨
USD
損益計算・収益性
営業活動
投資活動
損益
$None
純利益
-$381,387,000
営業キャッシュフロー
-$268,583,000
営業活動による支払い
$None
営業活動によるキャッシュフロー
$None
営業活動に関連する負債の増減額
$None
営業活動に関連する資産の増減額
$None
売掛金の増減額
$None
在庫資産の増減額
-$13,674,000
減価償却・減耗費・償却費
$22,694,000
投資活動によるキャッシュフロー
-$277,776,000
設備投資
$51,444,000
財務活動
資金・為替照合
財務活動によるキャッシュフロー
$675,840,000
短期融資回収金
$None
自社株買い支出（普通株）
$None
自社株買い支出（優先株）
$None
自社株買い支出
$None
配当支払い（普通株）
$None
配当支払い（優先株）
$None
配当支払い
$None
資金調達（普通株）
$None
資金調達（優先株）
$None
資金調達（長期債・資本証券）
$None
自社株売却による収益
$None
自社株再取得による収益
$None
現金及び現金同等物の増減額
$None
為替レートの変動による増減額
$None
発行済株式数
広告パネル
スポンサー紹介
本物のネイティブ講師による
オンライン英会話DOJO
『ネイティブDOJO』はインターナショナルスクールと同様に、英語圏出身の経験豊富なネイティブ教師のみが指導します。グループ予約すれば、中学生・高校生・大学生・社会人のバイリンガルへの道が楽しく低コストで済みます。
ネイティブDOJOについて詳しく知る